ENSG00000197548


Homo sapiens

Features
Gene ID: ENSG00000197548
  
Biological name :ATG7
  
Synonyms : ATG7 / autophagy related 7 / O95352
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: p25.3
Gene start: 11272309
Gene end: 11557665
  
Corresponding Affymetrix probe sets: 1569827_at (Human Genome U133 Plus 2.0 Array)   218673_s_at (Human Genome U133 Plus 2.0 Array)   222709_at (Human Genome U133 Plus 2.0 Array)   224025_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000407340
Ensembl peptide - ENSP00000406398
Ensembl peptide - ENSP00000408303
Ensembl peptide - ENSP00000416644
Ensembl peptide - ENSP00000415223
Ensembl peptide - ENSP00000412580
Ensembl peptide - ENSP00000411880
Ensembl peptide - ENSP00000409844
Ensembl peptide - ENSP00000346437
Ensembl peptide - ENSP00000347042
Ensembl peptide - ENSP00000388295
Ensembl peptide - ENSP00000389012
Ensembl peptide - ENSP00000389996
Ensembl peptide - ENSP00000390547
Ensembl peptide - ENSP00000393075
NCBI entrez gene - 10533     See in Manteia.
OMIM - 608760
RefSeq - XM_017005554
RefSeq - XM_011533279
RefSeq - XM_011533280
RefSeq - XM_011533281
RefSeq - XM_011533282
RefSeq - XM_011533283
RefSeq - XM_011533284
RefSeq - XM_011533285
RefSeq - XM_011533286
RefSeq - XM_017005542
RefSeq - XM_017005543
RefSeq - XM_017005544
RefSeq - XM_017005545
RefSeq - XM_017005546
RefSeq - XM_017005547
RefSeq - XM_017005548
RefSeq - XM_017005549
RefSeq - XM_017005550
RefSeq - XM_017005551
RefSeq - XM_017005552
RefSeq - XM_017005553
RefSeq - NM_001136031
RefSeq - NM_001144912
RefSeq - NM_001349232
RefSeq - NM_001349233
RefSeq - NM_001349234
RefSeq - NM_001349235
RefSeq - NM_006395
RefSeq - XM_006712931
RefSeq - XM_006712932
RefSeq - XM_006712933
RefSeq - XM_011533277
RefSeq - XM_011533278
RefSeq Peptide - NP_001336163
RefSeq Peptide - NP_001336164
RefSeq Peptide - NP_006386
RefSeq Peptide - NP_001336161
RefSeq Peptide - NP_001336162
RefSeq Peptide - NP_001129503
RefSeq Peptide - NP_001138384
swissprot - H7C059
swissprot - H7C2J8
swissprot - H7C2R3
swissprot - C9JNU2
swissprot - O95352
swissprot - C9J415
swissprot - H7C369
swissprot - C9JKA3
swissprot - C9JGL2
swissprot - C9JFF4
swissprot - C9JE55
swissprot - F8WDY9
swissprot - H7BZ92
Ensembl - ENSG00000197548
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atg7ENSDARG00000102893Danio rerio
 ATG7ENSGALG00000004932Gallus gallus
 Atg7ENSMUSG00000030314Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000594  THIF-type NAD/FAD binding fold
 IPR006285  Ubiquitin-like modifier-activating enzyme Atg7
 IPR032197  Ubiquitin-like modifier-activating enzyme Atg7, N-terminal
 IPR035985  Ubiquitin-activating enzyme


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000045 autophagosome assembly IBA
 biological_processGO:0000422 autophagy of mitochondrion IGI
 biological_processGO:0006464 cellular protein modification process TAS
 biological_processGO:0006497 protein lipidation IDA
 biological_processGO:0006501 C-terminal protein lipidation IBA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0006995 cellular response to nitrogen starvation IBA
 biological_processGO:0007568 aging IEA
 biological_processGO:0009267 cellular response to starvation IDA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0010508 positive regulation of autophagy IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016236 macroautophagy IMP
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0031401 positive regulation of protein modification process IDA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0034727 piecemeal microautophagy of the nucleus IBA
 biological_processGO:0039521 suppression by virus of host autophagy IMP
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0044805 late nucleophagy IBA
 biological_processGO:0045732 positive regulation of protein catabolic process IMP
 biological_processGO:0051607 defense response to virus IMP
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0061025 membrane fusion TAS
 biological_processGO:0071315 cellular response to morphine IEA
 biological_processGO:0071455 cellular response to hyperoxia IDA
 biological_processGO:0075044 autophagy of host cells involved in interaction with symbiont IGI
 biological_processGO:0090298 negative regulation of mitochondrial DNA replication IEA
 biological_processGO:1901214 regulation of neuron death IEA
 biological_processGO:1902617 response to fluoride IEA
 biological_processGO:1903204 negative regulation of oxidative stress-induced neuron death IEA
 cellular_componentGO:0000407 phagophore assembly site IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005930 axoneme ISS
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0034774 secretory granule lumen TAS
 cellular_componentGO:1904813 ficolin-1-rich granule lumen TAS
 molecular_functionGO:0004839 ubiquitin activating enzyme activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0008641 ubiquitin-like modifier activating enzyme activity IEA
 molecular_functionGO:0019778 Atg12 activating enzyme activity ISS
 molecular_functionGO:0019779 Atg8 activating enzyme activity IBA
 molecular_functionGO:0042803 protein homodimerization activity IDA


Pathways (from Reactome)
Pathway description
Macroautophagy
Neutrophil degranulation
Signaling by BRAF and RAF fusions
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000152348 ATG10 / Q9H0Y0 / autophagy related 10  / complex / reaction
 ENSG00000144848 ATG3 / Q9NT62 / autophagy related 3  / complex / reaction
 ENSG00000197548 ATG7 / O95352 / autophagy related 7  / complex
 ENSG00000145782 ATG12 / O94817 / autophagy related 12  / reaction / complex






 

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contact: otassy@igbmc.fr