ENSG00000197111


Homo sapiens

Features
Gene ID: ENSG00000197111
  
Biological name :PCBP2
  
Synonyms : PCBP2 / poly(rC) binding protein 2 / Q15366
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q13.13
Gene start: 53452102
Gene end: 53481162
  
Corresponding Affymetrix probe sets: 204031_s_at (Human Genome U133 Plus 2.0 Array)   213263_s_at (Human Genome U133 Plus 2.0 Array)   213264_at (Human Genome U133 Plus 2.0 Array)   213517_at (Human Genome U133 Plus 2.0 Array)   229467_at (Human Genome U133 Plus 2.0 Array)   237813_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000456842
Ensembl peptide - ENSP00000456412
Ensembl peptide - ENSP00000456795
Ensembl peptide - ENSP00000352228
Ensembl peptide - ENSP00000352438
Ensembl peptide - ENSP00000388008
Ensembl peptide - ENSP00000390304
Ensembl peptide - ENSP00000394116
Ensembl peptide - ENSP00000408949
Ensembl peptide - ENSP00000446601
Ensembl peptide - ENSP00000447068
Ensembl peptide - ENSP00000447670
Ensembl peptide - ENSP00000448079
Ensembl peptide - ENSP00000448672
Ensembl peptide - ENSP00000448762
Ensembl peptide - ENSP00000448847
Ensembl peptide - ENSP00000448927
Ensembl peptide - ENSP00000449062
Ensembl peptide - ENSP00000449070
Ensembl peptide - ENSP00000454797
NCBI entrez gene - 5094     See in Manteia.
OMIM - 601210
RefSeq - NM_001128911
RefSeq - NM_031989
RefSeq - NM_005016
RefSeq - NM_001128914
RefSeq - NM_001128913
RefSeq - NM_001128912
RefSeq - NM_001098620
RefSeq Peptide - NP_001122384
RefSeq Peptide - NP_001092090
RefSeq Peptide - NP_001122383
RefSeq Peptide - NP_001122385
RefSeq Peptide - NP_001122386
RefSeq Peptide - NP_005007
RefSeq Peptide - NP_114366
swissprot - F8VZX2
swissprot - F8VXH9
swissprot - F8VTZ0
swissprot - F8VRH0
swissprot - Q15366
swissprot - H3BSP4
swissprot - H3BSS4
swissprot - H3BRU6
swissprot - H3BND9
swissprot - F8W1G6
swissprot - F8W0G4
Ensembl - ENSG00000197111
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:110045ENSDARG00000110961Danio rerio
 ENSGALG00000041030Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PCBP1 / Q15365 / poly(rC) binding protein 1ENSG0000016956483
PCBP3 / P57721 / poly(rC) binding protein 3ENSG0000018357072
PCBP4 / P57723 / poly(rC) binding protein 4ENSG0000009009753
HNRNPK / P61978 / heterogeneous nuclear ribonucleoprotein KENSG0000016511933
NOVA1 / P51513 / NOVA alternative splicing regulator 1ENSG0000013991027
NOVA2 / Q9UNW9 / NOVA alternative splicing regulator 2ENSG0000010496727


Protein motifs (from Interpro)
Interpro ID Name
 IPR004087  K Homology domain
 IPR004088  K Homology domain, type 1
 IPR036612  K Homology domain, type 1 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000398 mRNA splicing, via spliceosome TAS
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0016070 RNA metabolic process TAS
 biological_processGO:0016071 mRNA metabolic process NAS
 biological_processGO:0032480 negative regulation of type I interferon production TAS
 biological_processGO:0039694 viral RNA genome replication IDA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0050687 negative regulation of defense response to virus IMP
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0075522 IRES-dependent viral translational initiation IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003723 RNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI


Pathways (from Reactome)
Pathway description
mRNA Splicing - Major Pathway
Processing of Capped Intron-Containing Pre-mRNA
Negative regulators of DDX58/IFIH1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000078747 ITCH / Q96J02 / itchy E3 ubiquitin protein ligase  / complex / reaction
 ENSG00000088888 MAVS / Q7Z434 / mitochondrial antiviral signaling protein  / reaction / complex
 ENSG00000107201 DDX58 / O95786 / DExD/H-box helicase 58  / complex / reaction
 ENSG00000115267 IFIH1 / Q9BYX4 / interferon induced with helicase C domain 1  / complex / reaction
 ENSG00000181481 Q8IUD6 / RNF135 / ring finger protein 135  / complex / reaction
 ENSG00000121060 Q14258 / TRIM25 / tripartite motif containing 25  / complex / reaction






 

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