ENSMUSG00000073705


Mus musculus

Features
Gene ID: ENSMUSG00000073705
  
Biological name :Cenps
  
Synonyms : Cenps / Centromere protein S / Q9D084
  
Possible biological names infered from orthology : Q8N2Z9
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: E2
Gene start: 149127121
Gene end: 149137629
  
Corresponding Affymetrix probe sets: 10518561 (MoGene1.0st)   1453067_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000101321
Ensembl peptide - ENSMUSP00000135536
Ensembl peptide - ENSMUSP00000134756
Ensembl peptide - ENSMUSP00000121878
Ensembl peptide - ENSMUSP00000030813
Ensembl peptide - ENSMUSP00000101320
NCBI entrez gene - 69928     See in Manteia.
MGI - MGI:1917178
RefSeq - NM_027263
RefSeq Peptide - NP_081539
swissprot - H3BKU9
swissprot - A6PWQ2
swissprot - Q9D084
swissprot - A6PWQ1
swissprot - A0A140T8U2
Ensembl - ENSMUSG00000073705
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cenpsENSDARG00000070485Danio rerio
 CENPSENSGALG00000024481Gallus gallus
 CENPSENSG00000175279Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009072  Histone-fold
 IPR029003  CENP-S/Mhf1
 IPR033554  Centromere protein S


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000712 resolution of meiotic recombination intermediates ISS
 biological_processGO:0006281 DNA repair ISS
 biological_processGO:0006312 mitotic recombination IBA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0031297 replication fork processing IBA
 biological_processGO:0036297 interstrand cross-link repair IBA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051382 kinetochore assembly IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0043240 Fanconi anaemia nuclear complex IBA
 cellular_componentGO:0071821 FANCM-MHF complex IBA
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003682 chromatin binding ISS
 molecular_functionGO:0003690 double-stranded DNA binding ISS
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Deposition of new CENPA-containing nucleosomes at the centromere
Fanconi Anemia Pathway
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000073705 Cenps / Q9D084 / Centromere protein S / Q8N2Z9*  / complex
 ENSMUSG00000055884 Fancm / Q8BGE5 / Fanconi anemia group M protein homolog / Q8IYD8* / Fanconi anemia complementation group M*  / complex
 ENSMUSG00000025144 Cenpx / Q8C4X1 / Mus musculus centromere protein X (Cenpx), transcript variant 3, mRNA. / A8MT69* / centromere protein X*  / complex
 ENSMUSG00000030493 Faap24 / Q8BHL6 / Fanconi anemia core complex-associated protein 24 / Q9BTP7*  / complex






 

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