ENSDARG00000001129


Danio rerio

Features
Gene ID: ENSDARG00000001129
  
Biological name :dicer1
  
Synonyms : dicer1 / dicer 1, ribonuclease type III / Q6TV19
  
Possible biological names infered from orthology : dicer 1, ribonuclease III / Q9UPY3
  
Species: Danio rerio
  
Chr. number: 17
Strand: -1
Band:
Gene start: 19419989
Gene end: 19466319
  
Corresponding Affymetrix probe sets: Dr.7201.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000133052
Ensembl peptide - ENSDARP00000045880
NCBI entrez gene - 324724     See in Manteia.
RefSeq - XM_005158666
RefSeq - XM_021467116
RefSeq - NM_001161453
RefSeq - XM_021467114
RefSeq - XM_005158665
RefSeq Peptide - NP_001154925
swissprot - Q6TV19
swissprot - A0A0R4IDJ0
ZFIN ID - ZDB-GENE-030131-3445
Ensembl - ENSDARG00000001129
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DICER1ENSGALG00000010999Gallus gallus
 DICER1ENSG00000100697Homo sapiens
 Dicer1ENSMUSG00000041415Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ifih1 / interferon induced with helicase C domain 1 / Q8R5F7* / Q9BYX4* / Interferon-induced helicase C domain-containing protein 1 *ENSDARG000000185539
dhx58 / DEXH (Asp-Glu-X-His) box polypeptide 58 / Q96C10* / DExH-box helicase 58*ENSDARG000000894638
fancm / Fanconi anemia, complementation group M / Q8IYD8*ENSDARG000001039333
CABZ01079748.1 / FANCM* / Q8IYD8* / Fanconi anemia complementation group M*ENSDARG000001121363


Protein motifs (from Interpro)
Interpro ID Name
 IPR000999  Ribonuclease III domain
 IPR001650  Helicase, C-terminal
 IPR003100  PAZ domain
 IPR005034  Dicer dimerisation domain
 IPR011545  DEAD/DEAH box helicase domain
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR014720  Double-stranded RNA-binding domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006309 apoptotic DNA fragmentation IBA
 biological_processGO:0006396 RNA processing IEA
 biological_processGO:0021591 ventricular system development IMP
 biological_processGO:0030422 production of siRNA involved in RNA interference IBA
 biological_processGO:0030423 targeting of mRNA for destruction involved in RNA interference ISS
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0031054 pre-miRNA processing IMP
 biological_processGO:0035195 gene silencing by miRNA IMP
 biological_processGO:0035196 production of miRNAs involved in gene silencing by miRNA IMP
 biological_processGO:0035279 mRNA cleavage involved in gene silencing by miRNA IGI
 biological_processGO:0050767 regulation of neurogenesis IMP
 biological_processGO:0090501 RNA phosphodiester bond hydrolysis IEA
 biological_processGO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016442 RISC complex IBA
 cellular_componentGO:0035068 micro-ribonucleoprotein complex ISS
 cellular_componentGO:0070578 RISC-loading complex ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004525 ribonuclease III activity IEA
 molecular_functionGO:0004530 deoxyribonuclease I activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016891 endoribonuclease activity, producing 5"-phosphomonoesters IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070883 pre-miRNA binding IDA


Pathways (from Reactome)
Pathway description
MicroRNA (miRNA) biogenesis
Small interfering RNA (siRNA) biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000017 endoderm endoderm endodermal cell decreased amount , abnormal
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 ZFA:0000023 forerunner cell group forerunner cell group decreased amount , abnormal
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 ZFA:0000029 hindbrain hindbrain neurogenesis increased occurrence , abnormal
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 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary morphology , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000360 heart tube heart tube morphology , abnormal
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 ZFA:0000554 olfactory epithelium olfactory epithelium immature , abnormal
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 ZFA:0001094 whole organism whole organism dead , abnormal
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 ZFA:0001114 head head decreased size , abnormal
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 ZFA:0001117 post-vent region post-vent region curved ventral , abnormal
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 ZFA:0001261 ventricular system ventricular system decreased volume , abnormal
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 ZFA:0001269 regenerating fin regenerating fin hypoplastic , abnormal
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 ZFA:0001317 endocardial cushion endocardial cushion mislocalised , abnormal
endocardial cushion poorly differentiated , abnormal
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 ZFA:0001320 endocardium endocardium poorly differentiated , abnormal
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 ZFA:0001615 ventricular endocardium ventricular endocardium endothelial cell cuboid , abnormal
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 ZFA:0005768 trigeminal sensory neuron trigeminal sensory neuron mislocalised , abnormal
trigeminal sensory neuron cell migration process quality , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000076718 prkra / B0V3F8 / protein kinase, interferon-inducible double stranded RNA dependent activator / O75569* / Q9WTX2* / protein activator of interferon induced protein kinase EIF2AK2* / Interfe...  / complex






 

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