ENSMUSG00000026374


Mus musculus

Features
Gene ID: ENSMUSG00000026374
  
Biological name :Tsn
  
Synonyms : Q62348 / translin / Tsn
  
Possible biological names infered from orthology : Q15631
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: E2.3
Gene start: 118294778
Gene end: 118311739
  
Corresponding Affymetrix probe sets: 10357124 (MoGene1.0st)   1416907_at (Mouse Genome 430 2.0 Array)   1416908_s_at (Mouse Genome 430 2.0 Array)   1448515_at (Mouse Genome 430 2.0 Array)   1448516_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027623
NCBI entrez gene - 22099     See in Manteia.
MGI - MGI:109263
RefSeq - NM_011650
RefSeq Peptide - NP_035780
swissprot - Q545E6
swissprot - Q62348
Ensembl - ENSMUSG00000026374
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tsnENSDARG00000041830Danio rerio
 TSNENSGALG00000011652Gallus gallus
 TSNENSG00000211460Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002848  Translin family
 IPR016068  Translin, N-terminal
 IPR033956  Translin
 IPR036081  Translin superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016070 RNA metabolic process IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding IEA
 molecular_functionGO:0003723 RNA binding IDA
 molecular_functionGO:0003729 mRNA binding IDA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
Small interfering RNA (siRNA) biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nkx2-1tm1Jaw/Nkx2-1tm1Jaw
Genetic Background: involves: 129S2/SvPas * CD-1

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nkx2-1tm1Jaw/Nkx2-1tm1Jaw
Genetic Background: involves: 129S2/SvPas * CD-1

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Nkx2-1tm1Jaw/Nkx2-1tm1Jaw
Genetic Background: involves: 129S2/SvPas * CD-1

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Nkx2-1tm1Jaw/Nkx2-1tm1Jaw
Genetic Background: involves: 129S2/SvPas * CD-1

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Nkx2-1tm1Jaw/Nkx2-1tm1Jaw
Genetic Background: involves: 129S2/SvPas * CD-1

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Nkx2-1tm1Jaw/Nkx2-1tm1Jaw
Genetic Background: involves: 129S2/SvPas * CD-1

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nkx2-1tm1Jaw/Nkx2-1tm1Jaw
Genetic Background: involves: 129S2/SvPas * CD-1

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Nkx2-1tm1Jaw/Nkx2-1tm1Jaw
Genetic Background: involves: 129S2/SvPas * CD-1

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nkx2-1tm1Jaw/Nkx2-1tm1Jaw
Genetic Background: involves: 129S2/SvPas * CD-1

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: LmnaGt(S7-1F1)Sor/LmnaGt(S7-1F1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Nkx2-1tm1Jaw/Nkx2-1tm1Jaw
Genetic Background: involves: 129S2/SvPas * CD-1

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Nkx2-1tm1Jaw/Nkx2-1tm1Jaw
Genetic Background: involves: 129S2/SvPas * CD-1

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nkx2-1tm1Jaw/Nkx2-1tm1Jaw
Genetic Background: involves: 129S2/SvPas * CD-1

 MP:0005656 decreased aggression "when compared to controls, subjects exhibit less than the normal level of domineering, assaultive posture and/or hostile physical action" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Nkx2-1tm1Jaw/Nkx2-1tm1Jaw
Genetic Background: involves: 129S2/SvPas * CD-1

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nkx2-1tm1Jaw/Nkx2-1tm1Jaw
Genetic Background: involves: 129S2/SvPas * CD-1

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx2-1tm1Jaw/Nkx2-1tm1Jaw
Genetic Background: involves: 129S2/SvPas * CD-1

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx2-1tm1Jaw/Nkx2-1tm1Jaw
Genetic Background: involves: 129S2/SvPas * CD-1

 MP:0009286 increased abdominal fat pad weight "greater than average weight of the encapsulated adipose tissue in the abdomen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx2-1tm1Jaw/Nkx2-1tm1Jaw
Genetic Background: involves: 129S2/SvPas * CD-1

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Nkx2-1tm1Jaw/Nkx2-1tm1Jaw
Genetic Background: involves: 129S2/SvPas * CD-1

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx2-1tm1Jaw/Nkx2-1tm1Jaw
Genetic Background: involves: 129S2/SvPas * CD-1

 MP:0012734 abnormal response to radiation "any anomaly in the physiological changes induced by ionizing radiation such as UV light, X-rays, or gamma rays" [MPD:Molly]
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Allelic Composition: LmnaGt(S7-1F1)Sor/LmnaGt(S7-1F1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000036698 Ago2 / Q8CJG0 / Protein argonaute-2 / Q9UKV8* / argonaute 2, RISC catalytic component*  / reaction
 ENSMUSG00000056820 Tsnax / Q9QZE7 / Translin-associated protein X / Q99598* / TSNAX-DISC1* / translin associated factor X* / TSNAX-DISC1 readthrough (NMD candidate)*  / complex
 ENSMUSG00000026374 Tsn / Q62348 / translin / Q15631*  / complex






 

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