ENSG00000134480


Homo sapiens

Features
Gene ID: ENSG00000134480
  
Biological name :CCNH
  
Synonyms : CCNH / cyclin H / P51946
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q14.3
Gene start: 87318416
Gene end: 87413019
  
Corresponding Affymetrix probe sets: 204093_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000494460
Ensembl peptide - ENSP00000426075
Ensembl peptide - ENSP00000426454
Ensembl peptide - ENSP00000493789
Ensembl peptide - ENSP00000256897
NCBI entrez gene - 902     See in Manteia.
OMIM - 601953
RefSeq - XM_017010014
RefSeq - NM_001199189
RefSeq - NM_001239
RefSeq - XM_005248627
RefSeq - XM_005248629
RefSeq - XM_011543706
RefSeq Peptide - NP_001186118
RefSeq Peptide - NP_001230
swissprot - D6RHI7
swissprot - P51946
swissprot - D6RG18
Ensembl - ENSG00000134480
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccnhENSDARG00000007657Danio rerio
 CCNHENSGALG00000015641Gallus gallus
 CcnhENSMUSG00000021548Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006671  Cyclin, N-terminal
 IPR013763  Cyclin-like
 IPR027081  CyclinH/Ccl1
 IPR031658  Cyclin, C-terminal domain 2
 IPR036915  Cyclin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle TAS
 biological_processGO:0000086 G2/M transition of mitotic cell cycle TAS
 biological_processGO:0006283 transcription-coupled nucleotide-excision repair TAS
 biological_processGO:0006294 nucleotide-excision repair, preincision complex assembly TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006361 transcription initiation from RNA polymerase I promoter TAS
 biological_processGO:0006362 transcription elongation from RNA polymerase I promoter TAS
 biological_processGO:0006363 termination of RNA polymerase I transcription TAS
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter TAS
 biological_processGO:0006370 7-methylguanosine mRNA capping TAS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity IBA
 biological_processGO:0045859 regulation of protein kinase activity IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0050821 protein stabilization IMP
 biological_processGO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain IBA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005675 holo TFIIH complex IDA
 cellular_componentGO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex IMP
 cellular_componentGO:0070985 TFIIK complex IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008094 DNA-dependent ATPase activity IDA
 molecular_functionGO:0008353 RNA polymerase II carboxy-terminal domain kinase activity IDA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity IEA


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Tat-mediated elongation of the HIV-1 transcript
NoRC negatively regulates rRNA expression
Formation of Incision Complex in GG-NER
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
Cyclin A:Cdk2-associated events at S phase entry
mRNA Capping
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase II Promoter Escape
RNA Polymerase I Chain Elongation
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Transcription Termination
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
RUNX1 regulates transcription of genes involved in differentiation of HSCs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000123374 CDK2 / P24941 / cyclin dependent kinase 2  / reaction
 ENSG00000170312 CDK1 / P06493 / cyclin dependent kinase 1  / reaction
 ENSG00000134058 CDK7 / P50613 / cyclin dependent kinase 7  / complex
 ENSG00000110092 CCND1 / P24385 / cyclin D1  / reaction
 ENSG00000135446 CDK4 / P11802 / cyclin dependent kinase 4  / reaction
 ENSG00000134057 CCNB1 / P14635 / cyclin B1  / reaction
 ENSG00000111276 CDKN1B / P46527 / cyclin dependent kinase inhibitor 1B  / reaction
 ENSG00000124762 CDKN1A / P38936 / cyclin dependent kinase inhibitor 1A  / reaction
 ENSG00000020426 MNAT1 / P51948 / MNAT1, CDK activating kinase assembly factor  / complex






 

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