ENSG00000134058


Homo sapiens

Features
Gene ID: ENSG00000134058
  
Biological name :CDK7
  
Synonyms : CDK7 / cyclin dependent kinase 7 / P50613
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q13.2
Gene start: 69234795
Gene end: 69277430
  
Corresponding Affymetrix probe sets: 211297_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000486479
Ensembl peptide - ENSP00000256443
Ensembl peptide - ENSP00000421559
Ensembl peptide - ENSP00000422027
Ensembl peptide - ENSP00000422121
Ensembl peptide - ENSP00000422737
Ensembl peptide - ENSP00000425043
Ensembl peptide - ENSP00000425893
Ensembl peptide - ENSP00000425983
Ensembl peptide - ENSP00000426372
Ensembl peptide - ENSP00000426561
Ensembl peptide - ENSP00000486415
NCBI entrez gene - 1022     See in Manteia.
OMIM - 601955
RefSeq - NM_001799
RefSeq - NM_001324078
RefSeq - NM_001324077
RefSeq - NM_001324075
RefSeq - NM_001324074
RefSeq - NM_001324072
RefSeq - NM_001324071
RefSeq - NM_001324069
RefSeq - NM_001324070
RefSeq - XM_011543094
RefSeq Peptide - NP_001311004
RefSeq Peptide - NP_001310998
RefSeq Peptide - NP_001310999
RefSeq Peptide - NP_001311000
RefSeq Peptide - NP_001311001
RefSeq Peptide - NP_001311003
RefSeq Peptide - NP_001311006
RefSeq Peptide - NP_001311007
RefSeq Peptide - NP_001790
swissprot - A0A0S2Z3F9
swissprot - P50613
swissprot - D6R9G1
swissprot - D6RIG9
swissprot - D6RI01
swissprot - D6RGG9
swissprot - D6RFL0
swissprot - D6RF14
swissprot - D6REC6
swissprot - D6RAD4
swissprot - D6R9Z2
Ensembl - ENSG00000134058
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdk7ENSDARG00000051916Danio rerio
 CDK7ENSGALG00000014790Gallus gallus
 Cdk7ENSMUSG00000069089Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CDK20 / Q8IZL9 / cyclin dependent kinase 20ENSG0000015634539
CDKL1 / Q00532 / cyclin dependent kinase like 1ENSG0000010049034
CDKL4 / Q5MAI5 / cyclin dependent kinase like 4ENSG0000020511134
CDKL5 / O76039 / cyclin dependent kinase like 5ENSG0000000808633
CDKL2 / Q92772 / cyclin dependent kinase like 2ENSG0000013876933
CDKL3 / Q8IVW4 / cyclin dependent kinase like 3ENSG0000000683730


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS
 biological_processGO:0000082 G1/S transition of mitotic cell cycle TAS
 biological_processGO:0000086 G2/M transition of mitotic cell cycle TAS
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006283 transcription-coupled nucleotide-excision repair TAS
 biological_processGO:0006294 nucleotide-excision repair, preincision complex assembly TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006361 transcription initiation from RNA polymerase I promoter TAS
 biological_processGO:0006362 transcription elongation from RNA polymerase I promoter TAS
 biological_processGO:0006363 termination of RNA polymerase I transcription TAS
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter TAS
 biological_processGO:0006370 7-methylguanosine mRNA capping TAS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007050 cell cycle arrest TAS
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030521 androgen receptor signaling pathway NAS
 biological_processGO:0042795 snRNA transcription by RNA polymerase II TAS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated NAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0050821 protein stabilization IMP
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005675 holo TFIIH complex IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex IMP
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070985 TFIIK complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003713 transcription coactivator activity NAS
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004693 cyclin-dependent protein serine/threonine kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0008094 DNA-dependent ATPase activity IDA
 molecular_functionGO:0008353 RNA polymerase II carboxy-terminal domain kinase activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0050681 androgen receptor binding NAS


Pathways (from Reactome)
Pathway description
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Tat-mediated elongation of the HIV-1 transcript
NoRC negatively regulates rRNA expression
Formation of Incision Complex in GG-NER
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
RNA polymerase II transcribes snRNA genes
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
Cyclin A:Cdk2-associated events at S phase entry
mRNA Capping
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase II Promoter Escape
RNA Polymerase I Chain Elongation
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Transcription Termination
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
RUNX1 regulates transcription of genes involved in differentiation of HSCs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000134480 CCNH / P51946 / cyclin H  / complex
 ENSG00000020426 MNAT1 / P51948 / MNAT1, CDK activating kinase assembly factor  / complex
 ENSG00000188342 GTF2F2 / P13984 / general transcription factor IIF subunit 2  / reaction
 ENSG00000135446 CDK4 / P11802 / cyclin dependent kinase 4  / reaction
 ENSG00000134057 CCNB1 / P14635 / cyclin B1  / reaction
 ENSG00000111276 CDKN1B / P46527 / cyclin dependent kinase inhibitor 1B  / reaction
 ENSG00000124762 CDKN1A / P38936 / cyclin dependent kinase inhibitor 1A  / reaction
 ENSG00000123374 CDK2 / P24941 / cyclin dependent kinase 2  / reaction
 ENSG00000125651 GTF2F1 / P35269 / general transcription factor IIF subunit 1  / reaction
 ENSG00000110092 CCND1 / P24385 / cyclin D1  / reaction
 ENSG00000170312 CDK1 / P06493 / cyclin dependent kinase 1  / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr