ENSG00000120539


Homo sapiens

Features
Gene ID: ENSG00000120539
  
Biological name :MASTL
  
Synonyms : MASTL / microtubule associated serine/threonine kinase like / Q96GX5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: p12.1
Gene start: 27154824
Gene end: 27186924
  
Corresponding Affymetrix probe sets: 228468_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000478938
Ensembl peptide - ENSP00000343446
Ensembl peptide - ENSP00000365107
Ensembl peptide - ENSP00000365113
NCBI entrez gene - 84930     See in Manteia.
OMIM - 608221
RefSeq - XM_017016856
RefSeq - NM_001172303
RefSeq - NM_001172304
RefSeq - NM_001320756
RefSeq - NM_001320757
RefSeq - NM_032844
RefSeq - XM_005252632
RefSeq - XM_006717519
RefSeq - XM_006717520
RefSeq - XM_017016852
RefSeq - XM_017016853
RefSeq - XM_017016854
RefSeq - XM_017016855
RefSeq - XM_005252631
RefSeq Peptide - NP_001165774
RefSeq Peptide - NP_001165775
RefSeq Peptide - NP_001307685
RefSeq Peptide - NP_001307686
RefSeq Peptide - NP_116233
swissprot - Q96GX5
swissprot - A0A087WUU7
Ensembl - ENSG00000120539
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mastlENSDARG00000055566Danio rerio
 MASTLENSGALG00000007507Gallus gallus
 MastlENSMUSG00000026779Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAST2 / Q6P0Q8 / microtubule associated serine/threonine kinase 2ENSG0000008601517
MAST4 / O15021 / microtubule associated serine/threonine kinase family member 4ENSG0000006902017
MAST1 / Q9Y2H9 / microtubule associated serine/threonine kinase 1ENSG0000010561317
MAST3 / O60307 / microtubule associated serine/threonine kinase 3ENSG0000009930817


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle IMP
 biological_processGO:0000278 mitotic cell cycle IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007147 female meiosis II IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0032515 negative regulation of phosphoprotein phosphatase activity IMP
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051441 obsolete positive regulation of ubiquitin-protein ligase activity involved in meiotic cell cycle IEA
 biological_processGO:0051726 regulation of cell cycle IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0032154 cleavage furrow IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0051721 protein phosphatase 2A binding ISS


Pathways (from Reactome)
Pathway description
MASTL Facilitates Mitotic Progression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
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 HP:0000978 Ecchymoses 
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 HP:0001873 Thrombocytopenia 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000134057 CCNB1 / P14635 / cyclin B1  / reaction
 ENSG00000170312 CDK1 / P06493 / cyclin dependent kinase 1  / reaction
 ENSG00000128989 ARPP19 / P56211 / cAMP regulated phosphoprotein 19  / reaction
 ENSG00000143420 ENSA / O43768 / endosulfine alpha  / reaction






 

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contact: otassy@igbmc.fr