ENSMUSG00000026779


Mus musculus

Features
Gene ID: ENSMUSG00000026779
  
Biological name :Mastl
  
Synonyms : Mastl / microtubule associated serine/threonine kinase-like / Q8C0P0
  
Possible biological names infered from orthology : Q96GX5
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: A3
Gene start: 23115606
Gene end: 23156024
  
Corresponding Affymetrix probe sets: 10480432 (MoGene1.0st)   1423524_at (Mouse Genome 430 2.0 Array)   1423525_at (Mouse Genome 430 2.0 Array)   1444725_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028119
NCBI entrez gene - 67121     See in Manteia.
MGI - MGI:1914371
RefSeq - XM_017319214
RefSeq - NM_025979
RefSeq - XM_006498239
RefSeq Peptide - NP_080255
swissprot - Q8C0P0
Ensembl - ENSMUSG00000026779
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mastlENSDARG00000055566Danio rerio
 MASTLENSGALG00000007507Gallus gallus
 MASTLENSG00000120539Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mast1 / Q9R1L5 / Microtubule-associated serine/threonine-protein kinase 1 / Q9Y2H9* / microtubule associated serine/threonine kinase 1*ENSMUSG0000005369317
Mast2 / microtubule associated serine/threonine kinase 2 / Q6P0Q8*ENSMUSG0000000381017
Mast3 / Q3U214 / Microtubule-associated serine/threonine-protein kinase 3 / O60307* / microtubule associated serine/threonine kinase 3*ENSMUSG0000003183317
Mast4 / Q811L6 / Microtubule-associated serine/threonine-protein kinase 4 / O15021* / microtubule associated serine/threonine kinase family member 4*ENSMUSG0000003475117


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle IEA
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007147 female meiosis II IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0032515 negative regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051441 obsolete positive regulation of ubiquitin-protein ligase activity involved in meiotic cell cycle IMP
 biological_processGO:0051726 regulation of cell cycle IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0032154 cleavage furrow IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0051721 protein phosphatase 2A binding ISS


Pathways (from Reactome)
Pathway description
MASTL Facilitates Mitotic Progression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tdrd12tm1Yam/Tdrd12tm1Yam
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Mastltm1.1Mama/Mastltm1.1Mama
Genetic Background: Not Specified

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mastltm1.1Mama/Mastltm1.1Mama,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: Not Specified

 MP:0009760 abnormal mitotic spindle "an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during mitosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"]
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Allelic Composition: Mastltm1.1Mama/Mastltm1.1Mama
Genetic Background: Not Specified

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Mastltm1.1Mama/Mastltm1.1Mama
Genetic Background: Not Specified

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Mastltm1.1Mama/Mastltm1.1Mama
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000038619 Ensa / P60840 / Alpha-endosulfine / O43768* / endosulfine alpha*  / reaction
 ENSMUSG00000007656 Arpp19 / P56212 / Mus musculus cAMP-regulated phosphoprotein 19 (Arpp19), transcript variant 6, mRNA. / P56211* / cAMP regulated phosphoprotein 19*  / reaction






 

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