ENSMUSG00000003810


Mus musculus

Features
Gene ID: ENSMUSG00000003810
  
Biological name :Mast2
  
Synonyms : Mast2 / microtubule associated serine/threonine kinase 2
  
Possible biological names infered from orthology : Q6P0Q8
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D1
Gene start: 116306762
Gene end: 116464183
  
Corresponding Affymetrix probe sets: 10515295 (MoGene1.0st)   1417324_at (Mouse Genome 430 2.0 Array)   1440321_at (Mouse Genome 430 2.0 Array)   1456927_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000003908
Ensembl peptide - ENSMUSP00000122625
Ensembl peptide - ENSMUSP00000118340
Ensembl peptide - ENSMUSP00000102095
Ensembl peptide - ENSMUSP00000102094
Ensembl peptide - ENSMUSP00000102093
NCBI entrez gene - 17776     See in Manteia.
MGI - MGI:894676
RefSeq - XM_017320018
RefSeq - NM_001042743
RefSeq - NM_008641
RefSeq - XM_006502833
RefSeq - XM_006502834
RefSeq - XM_006502835
RefSeq - XM_006502836
RefSeq - XM_006502840
RefSeq Peptide - NP_032667
RefSeq Peptide - NP_001036208
swissprot - B1AST7
swissprot - B1AST6
swissprot - B1AST5
swissprot - E9Q1Q1
swissprot - E9QLW6
swissprot - B1AST8
Ensembl - ENSMUSG00000003810
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mast2ENSDARG00000074311Danio rerio
 MAST2ENSG00000086015Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mast4 / Q811L6 / Microtubule-associated serine/threonine-protein kinase 4 / O15021* / microtubule associated serine/threonine kinase family member 4*ENSMUSG0000003475157
Mast1 / Q9R1L5 / Microtubule-associated serine/threonine-protein kinase 1 / Q9Y2H9* / microtubule associated serine/threonine kinase 1*ENSMUSG0000005369355
Mast3 / Q3U214 / Microtubule-associated serine/threonine-protein kinase 3 / O60307* / microtubule associated serine/threonine kinase 3*ENSMUSG0000003183345
Mastl / Q8C0P0 / microtubule associated serine/threonine kinase-like / Q96GX5*ENSMUSG000000267798


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR001478  PDZ domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR015022  Microtubule-associated serine/threonine-protein kinase, domain
 IPR023142  Microtubule-associated serine/threonine-protein kinase, pre-PK domain superfamily
 IPR028779  Microtubule-associated serine/threonine-protein kinase 2
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0045075 regulation of interleukin-12 biosynthetic process IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019902 phosphatase binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

 MP:0005344 increased circulating bilirubin level "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

 MP:0008210 increased mature B cell number "greater number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

 MP:0008347 decreased gamma-delta T cell number "reduced number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
Show

Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Jam3tm1.1(KOMP)Vlcg/Jam3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Jam3tm1.1(KOMP)Vlcg/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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