ENSG00000164109


Homo sapiens

Features
Gene ID: ENSG00000164109
  
Biological name :MAD2L1
  
Synonyms : MAD2L1 / mitotic arrest deficient 2 like 1 / Q13257
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q27
Gene start: 120055608
Gene end: 120067074
  
Corresponding Affymetrix probe sets: 1554768_a_at (Human Genome U133 Plus 2.0 Array)   203362_s_at (Human Genome U133 Plus 2.0 Array)   236312_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000296509
Ensembl peptide - ENSP00000425702
Ensembl peptide - ENSP00000332295
NCBI entrez gene - 4085     See in Manteia.
OMIM - 601467
RefSeq - NM_002358
RefSeq Peptide - NP_002349
swissprot - D6RJE3
swissprot - Q13257
Ensembl - ENSG00000164109
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mad2l1ENSDARG00000004713Danio rerio
 MAD2L1ENSGALG00000011967Gallus gallus
 Mad2l1ENSMUSG00000029910Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003511  HORMA domain
 IPR027097  Mitotic spindle checkpoint protein Mad2
 IPR036570  HORMA domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000070 mitotic sister chromatid segregation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0007093 mitotic cell cycle checkpoint IGI
 biological_processGO:0007094 mitotic spindle assembly checkpoint IEA
 biological_processGO:0031145 anaphase-promoting complex-dependent catabolic process TAS
 biological_processGO:0042177 negative regulation of protein catabolic process IDA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0045930 negative regulation of mitotic cell cycle IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051436 obsolete negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
 biological_processGO:0051437 obsolete positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition TAS
 biological_processGO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint IMP
 biological_processGO:1904667 negative regulation of ubiquitin protein ligase activity IDA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005643 nuclear pore IDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0072686 mitotic spindle IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IPI


Pathways (from Reactome)
Pathway description
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Inactivation of APC/C via direct inhibition of the APC/C complex
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
APC/C:Cdc20 mediated degradation of mitotic proteins
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000156970 BUB1B / O60566 / BUB1 mitotic checkpoint serine/threonine kinase B  / reaction / complex
 ENSG00000154473 BUB3 / O43684 / BUB3, mitotic checkpoint protein  / complex / reaction
 ENSG00000117650 NEK2 / P51955 / NIMA related kinase 2  / reaction / complex
 ENSG00000117399 CDC20 / Q12834 / cell division cycle 20  / reaction / complex
 ENSG00000002822 MAD1L1 / Q9Y6D9 / mitotic arrest deficient 1 like 1  / complex / reaction
 ENSG00000170312 CDK1 / P06493 / cyclin dependent kinase 1  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr