ENSGALG00000011967


Gallus gallus

Features
Gene ID: ENSGALG00000011967
  
Biological name :MAD2L1
  
Synonyms : MAD2L1 / mitotic arrest deficient 2 like 1
  
Possible biological names infered from orthology : Mitotic spindle assembly checkpoint protein MAD2A / Q13257 / Q9Z1B5
  
Species: Gallus gallus
  
Chr. number: 4
Strand: 1
Band:
Gene start: 54891140
Gene end: 54894597
  
Corresponding Affymetrix probe sets: Gga.1984.2.A1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000019493
Ensembl peptide - ENSGALP00000062341
Ensembl peptide - ENSGALP00000060678
Ensembl peptide - ENSGALP00000059749
Ensembl peptide - ENSGALP00000059093
Ensembl peptide - ENSGALP00000058956
Ensembl peptide - ENSGALP00000056661
NCBI entrez gene - 422675     See in Manteia.
RefSeq - NM_001277749
RefSeq Peptide - NP_001264678
swissprot - A0A1L1RPF2
swissprot - A0A1L1RLV7
swissprot - E1BUL1
swissprot - A0A1L1RJN3
swissprot - A0A1L1RK10
swissprot - A0A1L1RU37
Ensembl - ENSGALG00000011967
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mad2l1ENSDARG00000004713Danio rerio
 MAD2L1ENSG00000164109Homo sapiens
 Mad2l1ENSMUSG00000029910Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003511  HORMA domain
 IPR027097  Mitotic spindle checkpoint protein Mad2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000070 mitotic sister chromatid segregation IEA
 biological_processGO:0007093 mitotic cell cycle checkpoint IEA
 biological_processGO:0007094 mitotic spindle assembly checkpoint IEA
 biological_processGO:0042177 negative regulation of protein catabolic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045930 negative regulation of mitotic cell cycle IEA
 biological_processGO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint IEA
 biological_processGO:1904667 negative regulation of ubiquitin protein ligase activity IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005643 nuclear pore IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0072686 mitotic spindle IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Inactivation of APC/C via direct inhibition of the APC/C complex
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
APC/C:Cdc20 mediated degradation of mitotic proteins
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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