ENSDARG00000004713


Danio rerio

Features
Gene ID: ENSDARG00000004713
  
Biological name :mad2l1
  
Synonyms : mad2l1 / MAD2 mitotic arrest deficient-like 1 (yeast)
  
Possible biological names infered from orthology : mitotic arrest deficient 2 like 1 / Mitotic spindle assembly checkpoint protein MAD2A / Q13257 / Q9Z1B5
  
Species: Danio rerio
  
Chr. number: 7
Strand: -1
Band:
Gene start: 57629370
Gene end: 57637779
  
Corresponding Affymetrix probe sets: Dr.4833.2.S1_at (Zebrafish Array)   NM_001017739_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000003616
NCBI entrez gene - 550434     See in Manteia.
RefSeq - NM_001017739
RefSeq Peptide - NP_001017739
swissprot - F1QHN1
ZFIN ID - ZDB-GENE-030515-3
Ensembl - ENSDARG00000004713
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MAD2L1ENSGALG00000011967Gallus gallus
 MAD2L1ENSG00000164109Homo sapiens
 Mad2l1ENSMUSG00000029910Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003511  HORMA domain
 IPR027097  Mitotic spindle checkpoint protein Mad2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007094 mitotic spindle assembly checkpoint IEA


Pathways (from Reactome)
Pathway description
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
Inactivation of APC/C via direct inhibition of the APC/C complex
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
APC/C:Cdc20 mediated degradation of mitotic proteins
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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