ENSG00000164611


Homo sapiens

Features
Gene ID: ENSG00000164611
  
Biological name :PTTG1
  
Synonyms : O95997 / pituitary tumor-transforming 1 / PTTG1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q33.3
Gene start: 160421822
Gene end: 160428744
  
Corresponding Affymetrix probe sets: 203554_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000431068
Ensembl peptide - ENSP00000344936
Ensembl peptide - ENSP00000377536
Ensembl peptide - ENSP00000430642
NCBI entrez gene - 9232     See in Manteia.
OMIM - 604147
RefSeq - NM_001282382
RefSeq - NM_001282383
RefSeq - NM_004219
RefSeq Peptide - NP_001269311
RefSeq Peptide - NP_001269312
RefSeq Peptide - NP_004210
swissprot - Q6IAL9
swissprot - E5RJR4
swissprot - O95997
Ensembl - ENSG00000164611
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PTTG1ENSGALG00000001506Gallus gallus
 Pttg1ENSMUSG00000020415Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PTTG2 / Q9NZH5 / pituitary tumor-transforming 2ENSG0000025025481


Protein motifs (from Interpro)
Interpro ID Name
 IPR006940  Securin sister-chromatid separation inhibitor


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IMP
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007059 chromosome segregation IEA
 biological_processGO:0007283 spermatogenesis TAS
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0031145 anaphase-promoting complex-dependent catabolic process TAS
 biological_processGO:0045143 homologous chromosome segregation IBA
 biological_processGO:0051276 chromosome organization IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:2000816 negative regulation of mitotic sister chromatid separation IBA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IMP
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0004869 cysteine-type endopeptidase inhibitor activity NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0030414 peptidase inhibitor activity IBA


Pathways (from Reactome)
Pathway description
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000117399 CDC20 / Q12834 / cell division cycle 20  / reaction / complex
 ENSG00000135476 ESPL1 / Q14674 / extra spindle pole bodies like 1, separase  / complex / reaction






 

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