ENSG00000135476


Homo sapiens

Features
Gene ID: ENSG00000135476
  
Biological name :ESPL1
  
Synonyms : ESPL1 / extra spindle pole bodies like 1, separase / Q14674
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q13.13
Gene start: 53268299
Gene end: 53293643
  
Corresponding Affymetrix probe sets: 204817_at (Human Genome U133 Plus 2.0 Array)   38158_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000257934
Ensembl peptide - ENSP00000447054
Ensembl peptide - ENSP00000449831
Ensembl peptide - ENSP00000456450
NCBI entrez gene - 9700     See in Manteia.
OMIM - 604143
RefSeq - XM_017020253
RefSeq - NM_012291
RefSeq - XM_006719705
RefSeq - XM_011539024
RefSeq - XM_011539025
RefSeq Peptide - NP_036423
swissprot - H3BRX7
swissprot - H3BM31
swissprot - Q14674
Ensembl - ENSG00000135476
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 espl1ENSDARG00000075354Danio rerio
 Espl1ENSMUSG00000058290Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR005314  Peptidase C50, separase
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR030397  SEPARIN core domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000070 mitotic sister chromatid segregation IEA
 biological_processGO:0000212 meiotic spindle organization IEA
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0000281 mitotic cytokinesis NAS
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0007059 chromosome segregation IEA
 biological_processGO:0007127 meiosis I IEA
 biological_processGO:0040001 establishment of mitotic spindle localization NAS
 biological_processGO:0045143 homologous chromosome segregation IEA
 biological_processGO:0045842 positive regulation of mitotic metaphase/anaphase transition NAS
 biological_processGO:0045875 negative regulation of sister chromatid cohesion NAS
 biological_processGO:0051307 meiotic chromosome separation IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0072686 mitotic spindle IBA
 molecular_functionGO:0003824 catalytic activity NAS
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity TAS
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Separation of Sister Chromatids


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000135476 ESPL1 / Q14674 / extra spindle pole bodies like 1, separase  / complex
 ENSG00000164611 PTTG1 / O95997 / pituitary tumor-transforming 1  / complex / reaction






 

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