ENSMUSG00000058290


Mus musculus

Features
Gene ID: ENSMUSG00000058290
  
Biological name :Espl1
  
Synonyms : Espl1 / Mus musculus extra spindle pole bodies 1, separase (Espl1), transcript variant 2, mRNA. / P60330
  
Possible biological names infered from orthology : extra spindle pole bodies like 1, separase / Q14674
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: F3
Gene start: 102296266
Gene end: 102324357
  
Corresponding Affymetrix probe sets: 10427166 (MoGene1.0st)   1433862_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000155304
Ensembl peptide - ENSMUSP00000155074
Ensembl peptide - ENSMUSP00000155469
Ensembl peptide - ENSMUSP00000155666
Ensembl peptide - ENSMUSP00000064465
NCBI entrez gene - 105988     See in Manteia.
MGI - MGI:2146156
RefSeq - XM_011245396
RefSeq - NM_001014976
RefSeq - NM_001356312
RefSeq - XM_006520257
RefSeq - XM_006520258
RefSeq - XM_006520259
RefSeq Peptide - NP_001343241
RefSeq Peptide - NP_001014976
swissprot - P60330
Ensembl - ENSMUSG00000058290
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 espl1ENSDARG00000075354Danio rerio
 ESPL1ENSG00000135476Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR005314  Peptidase C50, separase
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR030397  SEPARIN core domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000070 mitotic sister chromatid segregation IEA
 biological_processGO:0000212 meiotic spindle organization IMP
 biological_processGO:0000278 mitotic cell cycle IGI
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007059 chromosome segregation IGI
 biological_processGO:0007127 meiosis I IMP
 biological_processGO:0045143 homologous chromosome segregation IMP
 biological_processGO:0051307 meiotic chromosome separation IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0072686 mitotic spindle IBA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IDA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Separation of Sister Chromatids


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000313 abnormal cell death "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm1Wahl/Trp53tm1Wahl
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm1Wahl/Trp53tm1Wahl
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Espl1tm1.1Tno/Espl1+,Pttg1tm1.1Tno/Pttg1tm1.1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Espl1tm1.1Tno/Espl1tm1.2Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm1Wahl/Trp53tm1Wahl
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001272 increased metastatic potential 
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Allelic Composition: Espl1Gt(XL058)Byg/Espl1+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: B6.129-Trp53tm1Tyj Espl1Gt(XL058)Byg

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm1Wahl/Trp53tm1Wahl
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm1Wahl/Trp53tm1Wahl
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Espl1Gt(XL058)Byg/Espl1+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: B6.129-Trp53tm1Tyj Espl1Gt(XL058)Byg

Allelic Composition: Espl1Gt(XL058)Byg/Espl1+,Trp53tm1Tyj/Trp53+
Genetic Background: B6.129-Trp53tm1Tyj Espl1Gt(XL058)Byg

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tgfbr1R244Q/Tgfbr1+
Genetic Background: either: (involves: C57BL/6) or (involves: BALB/c * C57BL/6)

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tgfbr1R244Q/Tgfbr1+
Genetic Background: either: (involves: C57BL/6) or (involves: BALB/c * C57BL/6)

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm1Wahl/Trp53tm1Wahl
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0002658 abnormal liver regeneration "deviation from the normal ability of liver to regenerate healthy tissue following partial hepatectomy" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm1Wahl/Trp53tm1Wahl
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0003111 abnormal nucleus morphology "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm1Wahl/Trp53tm1Wahl
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Espl1tm1.1Tno/Espl1tm1.2Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Espl1tm1.2Tno/Espl1tm1.2Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003702 abnormal chromosome morphology "anomalies in the structure of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information " [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Ctla4tm1Shr/Ctla4tm1Shr
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Espl1tm1.1Tno/Espl1+,Pttg1tm1.1Tno/Pttg1tm1.1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tbk1tm1Aki/Tbk1tm1Aki,Tnftm1Sek/Tnftm1Sek
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Espl1Gt(XL058)Byg/Espl1+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: B6.129-Trp53tm1Tyj Espl1Gt(XL058)Byg

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm1Wahl/Trp53tm1Wahl
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Espl1tm2Pzg/Espl1+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

Allelic Composition: Espl1tm1.1Kna/Espl1tm1.2Kna,Wapltm1.1Jmpt/Wapltm1.2Jmpt,Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NTac * SJL

 MP:0004760 increased mitotic index "increased number of cells in G2/M phase" [Bertram_Weiss:Bayer_Schering_Pharma_AG]
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Allelic Composition: Espl1tm2Pzg/Espl1+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0004957 abnormal blastocyst morphology "any structural anomaly of the preimplantation embryo of mammals consisting of a hollow sphere of cells with an outer cell layer (trophoblast) that forms the placenta, a fluid-filled cavity (blastocoele), and a cluster of cells on the interior (the inner cell mass) that forms the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Espl1tm1.2Tno/Espl1tm1.2Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004966 abnormal inner cell mass proliferation "any anomaly in the ability of the inner cell mass population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Espl1tm1.2Tno/Espl1tm1.2Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0006205 embryonic lethality before somite formation "death anytime after implantation but before somite formation (E4.5 to less than E8)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tgfbr1R244Q/Tgfbr1+
Genetic Background: either: (involves: C57BL/6) or (involves: BALB/c * C57BL/6)

 MP:0006207 embryonic lethality during organogenesis "death anytime after embryo turning but before the completion of organogenesis (E9 to less than E14)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tcf3tm1Wein/Tcf3tm3Zhu
Genetic Background: involves: 129/Sv * 129S4/SvJaeSor * C57BL/6

 MP:0006362 abnormal male germ cell morphology "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Espl1tm2Pzg/Espl1+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0006378 abnormal spermatogonia morphology "anomaly in the number, structure or development of the large unspecialized male germ cells that give rise to spermatocytes" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Espl1tm2Pzg/Espl1+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Espl1tm2Pzg/Espl1+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Espl1tm2Pzg/Espl1+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0008390 abnormal primordial germ cell proliferation "anomaly in the ability of the primordial germ cell population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Espl1tm2Pzg/Espl1+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0008393 absent primordial germ cells "absence of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Espl1tm2Pzg/Espl1+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Espl1Gt(XL058)Byg/Espl1+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: B6.129-Trp53tm1Tyj Espl1Gt(XL058)Byg

 MP:0009332 abnormal splenocyte morphology "any structural anomaly of a cell of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Espl1Gt(XL058)Byg/Espl1+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: B6.129-Trp53tm1Tyj Espl1Gt(XL058)Byg

 MP:0009336 increased splenocyte proliferation "increase in the expansion rate of a splenocyte cell population by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Espl1Gt(XL058)Byg/Espl1+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: B6.129-Trp53tm1Tyj Espl1Gt(XL058)Byg

 MP:0009760 abnormal mitotic spindle "an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during mitosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm1Wahl/Trp53tm1Wahl
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0010639 altered tumor pathology "any changes associated with the chemistry, immunohistology, cellular alterations or environmental interactions of tumors compared to the expected state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Espl1Gt(XL058)Byg/Espl1+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: B6.129-Trp53tm1Tyj Espl1Gt(XL058)Byg

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Espl1tm1.1Tno/Espl1+,Pttg1tm1.1Tno/Pttg1tm1.1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Espl1tm1.2Tno/Espl1tm1.2Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm1Wahl/Trp53tm1Wahl
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm1Wahl/Trp53tm1Wahl
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0011411 abnormal gonadal ridge morphology "any structural anomaly of the elevation of thickened mesothelium and underlying mesenchyme found on the ventromedial border of the embryonic mesonephros in which the primordial germ cells become embedded, establishing it as the primordium of the testis or ovary" [MGI:anna]
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Allelic Composition: Espl1tm2Pzg/Espl1+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Espl1Gt(XL058)Byg/Espl1+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: B6.129-Trp53tm1Tyj Espl1Gt(XL058)Byg

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020415 Pttg1 / Q9CQJ7 / Securin / PTTG2* / O95997* / Q9NZH5* / pituitary tumor-transforming 1* / pituitary tumor-transforming 2*  / complex / reaction
 ENSMUSG00000058290 Espl1 / P60330 / Mus musculus extra spindle pole bodies 1, separase (Espl1), transcript variant 2, mRNA. / Q14674* / extra spindle pole bodies like 1, separase*  / complex






 

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