ENSDARG00000042233


Danio rerio

Features
Gene ID: ENSDARG00000042233
  
Biological name :fgf16
  
Synonyms : fgf16 / fibroblast growth factor 16 / Q2HXK8
  
Possible biological names infered from orthology : O43320 / Q9ESL8
  
Species: Danio rerio
  
Chr. number: 14
Strand: -1
Band:
Gene start: 10751249
Gene end: 10762629
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000061927
swissprot - Q2HXK8
ZFIN ID - ZDB-GENE-060427-3
Ensembl - ENSDARG00000042233
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FGF16ENSGALG00000007806Gallus gallus
 FGF16ENSG00000196468Homo sapiens
 Fgf16ENSMUSG00000031230Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
fgf20b / fibroblast growth factor 20b / FGF20* / Q9NP95* / Q9ESL9* / fibroblast growth factor 20*ENSDARG0000008607064
fgf20a / fibroblast growth factor 20a / FGF20* / Q9NP95* / Q9ESL9* / fibroblast growth factor 20*ENSDARG0000000735660
fgf3 / P48802 / fibroblast growth factor 3 / P11487*ENSDARG0000010154033
fgf11a / fibroblast growth factor 11a / FGF11* / Q92914* / P70378* / fibroblast growth factor 11*ENSDARG0000006966233
fgf11b / fibroblast growth factor 11b / FGF11* / Q92914* / P70378* / fibroblast growth factor 11*ENSDARG0000004390732
fgf14 / fibroblast growth factor 14 / Q92915*ENSDARG0000004098231
fgf22 / fibroblast growth factor 22 / Q9ESS2* / Q9HCT0*ENSDARG0000007651031
fgf13a / fibroblast growth factor 13a / FGF13* / P70377* / Q92913* / fibroblast growth factor 13* / Mus musculus fibroblast growth factor 13 (Fgf13), transcript variant 4, mRNA.*ENSDARG0000003505631
fgf12a / fibroblast growth factor 12a / FGF12* / P61329* / P61328* / fibroblast growth factor 12*ENSDARG0000002795730
fgf5 / fibroblast growth factor 5 / P12034* / P15656*ENSDARG0000003537730
fgf12b / fibroblast growth factor 12b / FGF12* / P61328* / fibroblast growth factor 12*ENSDARG0000011352529
fgf13b / fibroblast growth factor 13b / FGF13* / P70377* / Q92913* / fibroblast growth factor 13* / Mus musculus fibroblast growth factor 13 (Fgf13), transcript variant 4, mRNA.*ENSDARG0000005663329
fgf4 / fibroblast growth factor 4 / P08620* / P11403*ENSDARG0000010523028
fgf6b / fibroblast growth factor 6b / FGF6* / P21658* / P10767* / fibroblast growth factor 6*ENSDARG0000004585627
fgf10a / fibroblast growth factor 10a / FGF10* / O35565* / O15520* / fibroblast growth factor 10*ENSDARG0000003093227
fgf9 / fibroblast growth factor 9ENSDARG0000007862527
fgf6a / fibroblast growth factor 6a / FGF6* / P21658* / P10767* / fibroblast growth factor 6*ENSDARG0000000935127
fgf10b / fibroblast growth factor 10b / FGF10* / O15520* / fibroblast growth factor 10*ENSDARG0000010047527
fgf7 / fibroblast growth factor 7 / P21781*ENSDARG0000005938723


Protein motifs (from Interpro)
Interpro ID Name
 IPR002209  Fibroblast growth factor family
 IPR008996  Cytokine IL1/FGF
 IPR028285  Fibroblast growth factor 16


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0021536 diencephalon development IMP
 biological_processGO:0021544 subpallium development IMP
 biological_processGO:0021846 cell proliferation in forebrain IMP
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0033278 cell proliferation in midbrain IMP
 biological_processGO:0033339 pectoral fin development IMP
 biological_processGO:0035138 pectoral fin morphogenesis IMP
 biological_processGO:0048709 oligodendrocyte differentiation IMP
 biological_processGO:0097154 GABAergic neuron differentiation IMP
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
FGFR4 ligand binding and activation
FGFR3c ligand binding and activation
FGFR2c ligand binding and activation
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000029 hindbrain hindbrain lacks all parts of type oligodendrocyte , abnormal
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 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary absent , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000101 diencephalon diencephalon neuron differentiation decreased process quality , abnormal
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 ZFA:0000109 forebrain forebrain morphology , abnormal
forebrain has fewer parts of type oligodendrocyte , abnormal
forebrain has fewer parts of type GABAergic neuron , abnormal
forebrain apoptotic process increased occurrence , abnormal
forebrain lacks all parts of type oligodendrocyte , abnormal
forebrain lacks all parts of type GABAergic neuron , abnormal
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 ZFA:0000128 midbrain midbrain morphology , abnormal
midbrain apoptotic process increased occurrence , abnormal
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 ZFA:0000141 pectoral fin bud pectoral fin bud absent , abnormal
pectoral fin bud decreased size , abnormal
pectoral fin bud decreased depth , abnormal
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 ZFA:0000304 ventral telencephalon ventral telencephalon neuron differentiation decreased process quality , abnormal
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 ZFA:0001000 mesenchyme pectoral fin mesenchyme pectoral fin cell proliferation decreased occurrence , abnormal
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 ZFA:0001094 whole organism whole organism morphology , abnormal
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 ZFA:0001115 trunk trunk bent , abnormal
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 ZFA:0001161 pectoral fin pectoral fin decreased size , abnormal
pectoral fin absent , abnormal
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 ZFA:0009276 GABAergic neuron GABAergic neuron decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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