ENSDARG00000105230


Danio rerio

Features
Gene ID: ENSDARG00000105230
  
Biological name :fgf4
  
Synonyms : fgf4 / fibroblast growth factor 4
  
Possible biological names infered from orthology : P08620 / P11403
  
Species: Danio rerio
  
Chr. number: 7
Strand: 1
Band:
Gene start: 54617060
Gene end: 54624876
  
Corresponding Affymetrix probe sets: Dr.10640.1.S1_at (Zebrafish Array)   NM_131635_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000135882
NCBI entrez gene - 570435     See in Manteia.
RefSeq - NM_131635
RefSeq Peptide - NP_571710
swissprot - Q9DFC9
ZFIN ID - ZDB-GENE-001006-1
Ensembl - ENSDARG00000105230
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FGF4ENSGALG00000007562Gallus gallus
 FGF4ENSG00000075388Homo sapiens
 Fgf4ENSMUSG00000050917Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
fgf6b / fibroblast growth factor 6b / FGF6* / P21658* / P10767* / fibroblast growth factor 6*ENSDARG0000004585658
fgf6a / fibroblast growth factor 6a / FGF6* / P21658* / P10767* / fibroblast growth factor 6*ENSDARG0000000935157
fgf13a / fibroblast growth factor 13a / FGF13* / P70377* / Q92913* / fibroblast growth factor 13* / Mus musculus fibroblast growth factor 13 (Fgf13), transcript variant 4, mRNA.*ENSDARG0000003505632
fgf5 / fibroblast growth factor 5 / P12034* / P15656*ENSDARG0000003537732
fgf20a / fibroblast growth factor 20a / FGF20* / Q9NP95* / Q9ESL9* / fibroblast growth factor 20*ENSDARG0000000735632
fgf14 / fibroblast growth factor 14 / Q92915*ENSDARG0000004098231
fgf9 / fibroblast growth factor 9ENSDARG0000007862531
fgf11a / fibroblast growth factor 11a / FGF11* / Q92914* / P70378* / fibroblast growth factor 11*ENSDARG0000006966231
fgf20b / fibroblast growth factor 20b / FGF20* / Q9NP95* / Q9ESL9* / fibroblast growth factor 20*ENSDARG0000008607031
fgf3 / P48802 / fibroblast growth factor 3 / P11487*ENSDARG0000010154031
fgf12a / fibroblast growth factor 12a / FGF12* / P61329* / P61328* / fibroblast growth factor 12*ENSDARG0000002795730
fgf11b / fibroblast growth factor 11b / FGF11* / Q92914* / P70378* / fibroblast growth factor 11*ENSDARG0000004390730
fgf22 / fibroblast growth factor 22 / Q9ESS2* / Q9HCT0*ENSDARG0000007651030
fgf13b / fibroblast growth factor 13b / FGF13* / P70377* / Q92913* / fibroblast growth factor 13* / Mus musculus fibroblast growth factor 13 (Fgf13), transcript variant 4, mRNA.*ENSDARG0000005663329
fgf16 / Q2HXK8 / fibroblast growth factor 16 / O43320* / Q9ESL8*ENSDARG0000004223329
fgf12b / fibroblast growth factor 12b / FGF12* / P61328* / fibroblast growth factor 12*ENSDARG0000011352529
fgf10a / fibroblast growth factor 10a / FGF10* / O35565* / O15520* / fibroblast growth factor 10*ENSDARG0000003093228
fgf7 / fibroblast growth factor 7 / P21781*ENSDARG0000005938727
fgf10b / fibroblast growth factor 10b / FGF10* / O15520* / fibroblast growth factor 10*ENSDARG0000010047526


Protein motifs (from Interpro)
Interpro ID Name
 IPR002209  Fibroblast growth factor family
 IPR008996  Cytokine IL1/FGF


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0060271 cilium assembly IMP
 biological_processGO:0070121 Kupffer"s vesicle development IMP
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
FGFR4 ligand binding and activation
FGFR3c ligand binding and activation
FGFR1c ligand binding and activation
FGFR2c ligand binding and activation
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
Downstream signaling of activated FGFR1
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
FGFRL1 modulation of FGFR1 signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle motile cilium decreased length , abnormal
Kupffers vesicle cilium decreased length , abnormal
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 ZFA:0000008 brain brain decreased size , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000114 heart heart mislocalised , abnormal
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 ZFA:0000123 liver liver mislocalised , abnormal
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 ZFA:0000140 pancreas pancreas mislocalised , abnormal
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 ZFA:0001115 trunk trunk bent , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000032617 fgfrl1a / fibroblast growth factor receptor like 1a / Q91V87* / FGFRL1* / Q8N441* / fibroblast growth factor receptor like 1*  / complex / reaction
 ENSDARG00000100475 fgf10b / fibroblast growth factor 10b / FGF10* / O15520* / fibroblast growth factor 10*  / reaction / complex
 ENSDARG00000076510 fgf22 / fibroblast growth factor 22 / Q9ESS2* / Q9HCT0*  / reaction / complex
 ENSDARG00000105230 fgf4 / fibroblast growth factor 4 / P08620* / P11403*  / complex / reaction
 ENSDARG00000101540 fgf3 / P48802 / fibroblast growth factor 3 / P11487*  / complex / reaction
 ENSDARG00000030932 fgf10a / fibroblast growth factor 10a / FGF10* / O35565* / O15520* / fibroblast growth factor 10*  / reaction / complex






 

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