ENSG00000111241


Homo sapiens

Features
Gene ID: ENSG00000111241
  
Biological name :FGF6
  
Synonyms : FGF6 / fibroblast growth factor 6 / P10767
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: p13.32
Gene start: 4428155
Gene end: 4445614
  
Corresponding Affymetrix probe sets: 208417_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000228837
Ensembl peptide - ENSP00000445479
NCBI entrez gene - 2251     See in Manteia.
OMIM - 134921
RefSeq - NM_020996
RefSeq Peptide - NP_066276
swissprot - P10767
swissprot - H0YGZ9
Ensembl - ENSG00000111241
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fgf6aENSDARG00000009351Danio rerio
 fgf6bENSDARG00000045856Danio rerio
 FGF6ENSGALG00000017287Gallus gallus
 Fgf6ENSMUSG00000000183Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FGF4 / P08620 / fibroblast growth factor 4ENSG0000007538852
FGF5 / P12034 / fibroblast growth factor 5ENSG0000013867535
FGF3 / P11487 / fibroblast growth factor 3ENSG0000018689531
FGF20 / Q9NP95 / fibroblast growth factor 20ENSG0000007857931
FGF9 / P31371 / fibroblast growth factor 9ENSG0000010267830
FGF10 / O15520 / fibroblast growth factor 10ENSG0000007019330
FGF16 / O43320 / fibroblast growth factor 16ENSG0000019646828
FGF11 / Q92914 / fibroblast growth factor 11ENSG0000016195827
FGF22 / Q9HCT0 / fibroblast growth factor 22ENSG0000007038826
FGF13 / Q92913 / fibroblast growth factor 13ENSG0000012968226
FGF7 / P21781 / fibroblast growth factor 7ENSG0000014028526
FGF12 / P61328 / fibroblast growth factor 12ENSG0000011427926
FGF14 / Q92915 / fibroblast growth factor 14ENSG0000010246625


Protein motifs (from Interpro)
Interpro ID Name
 IPR002209  Fibroblast growth factor family
 IPR008996  Cytokine IL1/FGF
 IPR028242  Fibroblast growth factor 6


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0001502 cartilage condensation IEA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0008284 positive regulation of cell proliferation IGI
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IGI
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA
 biological_processGO:0045445 myoblast differentiation IEA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling TAS
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0042383 sarcolemma IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0008083 growth factor activity TAS
 molecular_functionGO:0016303 1-phosphatidylinositol-3-kinase activity TAS
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
Signaling by activated point mutants of FGFR1
FGFR4 ligand binding and activation
FGFR1c ligand binding and activation
FGFR2c ligand binding and activation
Activated point mutants of FGFR2
Constitutive Signaling by Aberrant PI3K in Cancer
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR4
Downstream signaling of activated FGFR1
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR4 signaling
Signaling by FGFR2 in disease
Signaling by FGFR1 in disease
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000102678 FGF9 / P31371 / fibroblast growth factor 9  / reaction / complex
 ENSG00000066468 FGFR2 / P21802 / fibroblast growth factor receptor 2  / complex / reaction
 ENSG00000111241 FGF6 / P10767 / fibroblast growth factor 6  / complex / reaction
 ENSG00000138685 FGF2 / P09038 / fibroblast growth factor 2  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr