ENSG00000138685


Homo sapiens

Features
Gene ID: ENSG00000138685
  
Biological name :FGF2
  
Synonyms : FGF2 / fibroblast growth factor 2 / P09038
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q28.1
Gene start: 122826708
Gene end: 122898236
  
Corresponding Affymetrix probe sets: 204421_s_at (Human Genome U133 Plus 2.0 Array)   204422_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000264498
Ensembl peptide - ENSP00000494222
Ensembl peptide - ENSP00000478620
Ensembl peptide - ENSP00000477134
NCBI entrez gene - 2247     See in Manteia.
OMIM - 134920
RefSeq - NM_002006
RefSeq Peptide - NP_001997
swissprot - D9ZGF5
swissprot - A0A0A0MQV6
swissprot - A0A087WUF6
swissprot - P09038
Ensembl - ENSG00000138685
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fgf2ENSDARG00000104348Danio rerio
 FGF2ENSGALG00000011835Gallus gallus
 Fgf2ENSMUSG00000037225Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FGF1 / P05230 / fibroblast growth factor 1ENSG0000011357829


Protein motifs (from Interpro)
Interpro ID Name
 IPR002209  Fibroblast growth factor family
 IPR008996  Cytokine IL1/FGF
 IPR028223  Fibroblast growth factor 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0000187 activation of MAPK activity TAS
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IDA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IDA
 biological_processGO:0002042 cell migration involved in sprouting angiogenesis IGI
 biological_processGO:0006661 phosphatidylinositol biosynthetic process IDA
 biological_processGO:0006935 chemotaxis TAS
 biological_processGO:0007165 signal transduction NAS
 biological_processGO:0007265 Ras protein signal transduction TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development TAS
 biological_processGO:0008284 positive regulation of cell proliferation IGI
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IPI
 biological_processGO:0009887 animal organ morphogenesis TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010764 negative regulation of fibroblast migration IDA
 biological_processGO:0010863 positive regulation of phospholipase C activity IDA
 biological_processGO:0014843 growth factor dependent regulation of skeletal muscle satellite cell proliferation IMP
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030198 extracellular matrix organization TAS
 biological_processGO:0030214 hyaluronan catabolic process IDA
 biological_processGO:0032958 inositol phosphate biosynthetic process IDA
 biological_processGO:0035019 somatic stem cell population maintenance TAS
 biological_processGO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA
 biological_processGO:0042060 wound healing TAS
 biological_processGO:0042660 positive regulation of cell fate specification IDA
 biological_processGO:0043406 positive regulation of MAP kinase activity IDA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IGI
 biological_processGO:0043537 negative regulation of blood vessel endothelial cell migration IDA
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IDA
 biological_processGO:0045765 regulation of angiogenesis TAS
 biological_processGO:0045766 positive regulation of angiogenesis IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0048598 embryonic morphogenesis TAS
 biological_processGO:0050918 positive chemotaxis IEA
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IDA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling TAS
 biological_processGO:0060045 positive regulation of cardiac muscle cell proliferation IDA
 biological_processGO:0060548 negative regulation of cell death IDA
 biological_processGO:0060591 chondroblast differentiation IDA
 biological_processGO:0061045 negative regulation of wound healing IDA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0072089 stem cell proliferation NAS
 biological_processGO:0090050 positive regulation of cell migration involved in sprouting angiogenesis IDA
 biological_processGO:1903672 positive regulation of sprouting angiogenesis IMP
 biological_processGO:1904707 positive regulation of vascular smooth muscle cell proliferation IGI
 biological_processGO:1905564 positive regulation of vascular endothelial cell proliferation IGI
 biological_processGO:2000544 regulation of endothelial cell chemotaxis to fibroblast growth factor IDA
 biological_processGO:2000546 positive regulation of endothelial cell chemotaxis to fibroblast growth factor IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IPI
 molecular_functionGO:0005125 cytokine activity IDA
 molecular_functionGO:0005178 integrin binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IDA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0016303 1-phosphatidylinositol-3-kinase activity TAS
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity IDA
 molecular_functionGO:0042056 chemoattractant activity IDA
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS
 molecular_functionGO:0090722 receptor-receptor interaction IDA


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
Signaling by activated point mutants of FGFR1
Signaling by activated point mutants of FGFR3
FGFR4 ligand binding and activation
FGFR1b ligand binding and activation
FGFR3c ligand binding and activation
FGFR1c ligand binding and activation
FGFR2c ligand binding and activation
FGFR2b ligand binding and activation
FGFR3 mutant receptor activation
Activated point mutants of FGFR2
Constitutive Signaling by Aberrant PI3K in Cancer
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Syndecan interactions
Non-integrin membrane-ECM interactions
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
Downstream signaling of activated FGFR1
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
Signaling by FGFR2 in disease
Signaling by FGFR1 in disease
FGFRL1 modulation of FGFR1 signaling
RAF/MAP kinase cascade
Interleukin-4 and Interleukin-13 signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Signaling by FGFR2 IIIa TM
Signaling by FGFR3 point mutants in cancer


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000111241 FGF6 / P10767 / fibroblast growth factor 6  / reaction / complex
 ENSG00000066468 FGFR2 / P21802 / fibroblast growth factor receptor 2  / reaction / complex
 ENSG00000138685 FGF2 / P09038 / fibroblast growth factor 2  / complex / reaction
 ENSG00000102678 FGF9 / P31371 / fibroblast growth factor 9  / complex / reaction
 ENSG00000137440 FGFBP1 / Q14512 / fibroblast growth factor binding protein 1  / reaction / complex






 

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