ENSG00000113578


Homo sapiens

Features
Gene ID: ENSG00000113578
  
Biological name :FGF1
  
Synonyms : FGF1 / fibroblast growth factor 1 / P05230
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q31.3
Gene start: 142592178
Gene end: 142698070
  
Corresponding Affymetrix probe sets: 1552721_a_at (Human Genome U133 Plus 2.0 Array)   205117_at (Human Genome U133 Plus 2.0 Array)   208240_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000479024
Ensembl peptide - ENSP00000480791
Ensembl peptide - ENSP00000481868
Ensembl peptide - ENSP00000480980
Ensembl peptide - ENSP00000338548
Ensembl peptide - ENSP00000352329
Ensembl peptide - ENSP00000354231
Ensembl peptide - ENSP00000367285
Ensembl peptide - ENSP00000378005
Ensembl peptide - ENSP00000383969
Ensembl peptide - ENSP00000396195
Ensembl peptide - ENSP00000399458
Ensembl peptide - ENSP00000404742
NCBI entrez gene - 2246     See in Manteia.
RefSeq - NM_001257208
RefSeq - NM_000800
RefSeq - NM_001144892
RefSeq - NM_001144934
RefSeq - NM_001144935
RefSeq - NM_001257205
RefSeq - NM_001257206
RefSeq - NM_001257207
RefSeq - NM_001257209
RefSeq - NM_001257210
RefSeq - NM_001257211
RefSeq - NM_001257212
RefSeq - NM_001354951
RefSeq - NM_001354952
RefSeq - NM_001354953
RefSeq - NM_001354958
RefSeq - NM_001354962
RefSeq - NM_033136
RefSeq - NM_033137
RefSeq - XM_005268390
RefSeq - XM_011537607
RefSeq Peptide - NP_149128
RefSeq Peptide - NP_000791
RefSeq Peptide - NP_001138364
RefSeq Peptide - NP_001138406
RefSeq Peptide - NP_001138407
RefSeq Peptide - NP_001244134
RefSeq Peptide - NP_001244135
RefSeq Peptide - NP_001244136
RefSeq Peptide - NP_001244137
RefSeq Peptide - NP_001244138
RefSeq Peptide - NP_001341891
RefSeq Peptide - NP_001341892
RefSeq Peptide - NP_001341893
RefSeq Peptide - NP_149127
RefSeq Peptide - NP_001244139
RefSeq Peptide - NP_001244140
RefSeq Peptide - NP_001244141
RefSeq Peptide - NP_001341880
RefSeq Peptide - NP_001341881
RefSeq Peptide - NP_001341882
RefSeq Peptide - NP_001341883
RefSeq Peptide - NP_001341884
RefSeq Peptide - NP_001341885
RefSeq Peptide - NP_001341887
RefSeq Peptide - NP_001341888
RefSeq Peptide - NP_001341890
swissprot - C9JUP6
swissprot - C9JDC5
swissprot - P05230
swissprot - B5MCF4
Ensembl - ENSG00000113578
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FGF1ENSGALG00000031255Gallus gallus
 Fgf1ENSMUSG00000036585Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FGF2 / P09038 / fibroblast growth factor 2ENSG0000013868554


Protein motifs (from Interpro)
Interpro ID Name
 IPR002209  Fibroblast growth factor family
 IPR008996  Cytokine IL1/FGF
 IPR028210  Fibroblast growth factor 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0000187 activation of MAPK activity IMP
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001759 organ induction IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0007165 signal transduction NAS
 biological_processGO:0007275 multicellular organism development TAS
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008284 positive regulation of cell proliferation IGI
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IPI
 biological_processGO:0009653 anatomical structure morphogenesis TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IMP
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0032148 activation of protein kinase B activity IMP
 biological_processGO:0034605 cellular response to heat IDA
 biological_processGO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IDA
 biological_processGO:0045542 positive regulation of cholesterol biosynthetic process IDA
 biological_processGO:0045766 positive regulation of angiogenesis IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling TAS
 biological_processGO:0060681 branch elongation involved in ureteric bud branching IDA
 biological_processGO:0072163 mesonephric epithelium development IDA
 biological_processGO:1901509 regulation of endothelial tube morphogenesis IMP
 biological_processGO:1902533 positive regulation of intracellular signal transduction IDA
 biological_processGO:1903672 positive regulation of sprouting angiogenesis IMP
 biological_processGO:2000544 regulation of endothelial cell chemotaxis to fibroblast growth factor IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005938 cell cortex IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IPI
 molecular_functionGO:0005178 integrin binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity TAS
 molecular_functionGO:0008201 heparin binding IMP
 molecular_functionGO:0016303 1-phosphatidylinositol-3-kinase activity TAS
 molecular_functionGO:0030544 Hsp70 protein binding IEA
 molecular_functionGO:0044548 S100 protein binding IPI
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
Signaling by activated point mutants of FGFR1
Signaling by activated point mutants of FGFR3
FGFR4 ligand binding and activation
FGFR1b ligand binding and activation
FGFR3b ligand binding and activation
FGFR3c ligand binding and activation
FGFR1c ligand binding and activation
FGFR2c ligand binding and activation
FGFR2b ligand binding and activation
FGFR3 mutant receptor activation
Activated point mutants of FGFR2
Constitutive Signaling by Aberrant PI3K in Cancer
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
Downstream signaling of activated FGFR1
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
Signaling by FGFR2 in disease
Signaling by FGFR1 in disease
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Signaling by FGFR2 IIIa TM
Signaling by FGFR3 point mutants in cancer


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000066468 FGFR2 / P21802 / fibroblast growth factor receptor 2  / complex / reaction






 

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