ENSMUSG00000036585


Mus musculus

Features
Gene ID: ENSMUSG00000036585
  
Biological name :Fgf1
  
Synonyms : Fgf1 / Fibroblast growth factor 1 / P61148
  
Possible biological names infered from orthology : P05230
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: B3
Gene start: 38838673
Gene end: 38929404
  
Corresponding Affymetrix probe sets: 10458560 (MoGene1.0st)   1423136_at (Mouse Genome 430 2.0 Array)   1441042_at (Mouse Genome 430 2.0 Array)   1450869_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113292
Ensembl peptide - ENSMUSP00000111245
Ensembl peptide - ENSMUSP00000122105
Ensembl peptide - ENSMUSP00000123293
Ensembl peptide - ENSMUSP00000122390
Ensembl peptide - ENSMUSP00000045710
NCBI entrez gene - 14164     See in Manteia.
MGI - MGI:95515
RefSeq - XM_017317831
RefSeq - XM_006525647
RefSeq - XM_006525648
RefSeq - XM_006525649
RefSeq - XM_011246841
RefSeq - XM_011246842
RefSeq - XM_011246843
RefSeq - XM_017317830
RefSeq - NM_010197
RefSeq - XM_006525641
RefSeq - XM_006525642
RefSeq - XM_006525644
RefSeq - XM_006525645
RefSeq Peptide - NP_034327
swissprot - D3Z6H1
swissprot - D3Z6E2
swissprot - D6RCX9
swissprot - P61148
swissprot - Q6ZWS1
swissprot - D3Z192
Ensembl - ENSMUSG00000036585
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FGF1ENSGALG00000031255Gallus gallus
 FGF1ENSG00000113578Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fgf2 / P15655 / Fibroblast growth factor 2 / P09038*ENSMUSG0000003722552


Protein motifs (from Interpro)
Interpro ID Name
 IPR002209  Fibroblast growth factor family
 IPR008996  Cytokine IL1/FGF
 IPR028210  Fibroblast growth factor 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity ISS
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001759 organ induction IDA
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008284 positive regulation of cell proliferation ISS
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration ISS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030324 lung development IDA
 biological_processGO:0030335 positive regulation of cell migration ISS
 biological_processGO:0032148 activation of protein kinase B activity ISO
 biological_processGO:0034605 cellular response to heat ISS
 biological_processGO:0043406 positive regulation of MAP kinase activity ISO
 biological_processGO:0045542 positive regulation of cholesterol biosynthetic process ISO
 biological_processGO:0045766 positive regulation of angiogenesis ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IDA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0060038 cardiac muscle cell proliferation TAS
 biological_processGO:0060681 branch elongation involved in ureteric bud branching ISO
 biological_processGO:0060979 vasculogenesis involved in coronary vascular morphogenesis TAS
 biological_processGO:0072163 mesonephric epithelium development ISO
 biological_processGO:1901509 regulation of endothelial tube morphogenesis ISS
 biological_processGO:1902533 positive regulation of intracellular signal transduction ISS
 biological_processGO:1903672 positive regulation of sprouting angiogenesis ISS
 biological_processGO:2000544 regulation of endothelial cell chemotaxis to fibroblast growth factor ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005938 cell cortex IEA
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0005178 integrin binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0030544 Hsp70 protein binding IEA
 molecular_functionGO:0044548 S100 protein binding ISS


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
FGFR4 ligand binding and activation
FGFR1b ligand binding and activation
FGFR3b ligand binding and activation
FGFR3c ligand binding and activation
FGFR1c ligand binding and activation
FGFR2c ligand binding and activation
FGFR2b ligand binding and activation
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
Downstream signaling of activated FGFR1
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgf1tm1Bas/Fgf1tm1Bas,Fgf2tm1Bas/Fgf2tm1Bas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Otx2tm1Sla/Otx2tm1Sla
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
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Allelic Composition: Otx2tm1Sla/Otx2tm1Sla
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008547 abnormal neocortex morphology "any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.885.213.420]
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Allelic Composition: Fgf1tm1Bas/Fgf1tm1Bas,Fgf2tm1Bas/Fgf2tm1Bas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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