ENSMUSG00000037225


Mus musculus

Features
Gene ID: ENSMUSG00000037225
  
Biological name :Fgf2
  
Synonyms : Fgf2 / Fibroblast growth factor 2 / P15655
  
Possible biological names infered from orthology : P09038
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: B
Gene start: 37348346
Gene end: 37410108
  
Corresponding Affymetrix probe sets: 10491699 (MoGene1.0st)   1449826_a_at (Mouse Genome 430 2.0 Array)   1456945_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000103755
Ensembl peptide - ENSMUSP00000122227
Ensembl peptide - ENSMUSP00000143094
Ensembl peptide - ENSMUSP00000088742
Ensembl peptide - ENSMUSP00000037694
NCBI entrez gene - 14173     See in Manteia.
MGI - MGI:95516
RefSeq - XM_006535399
RefSeq - NM_008006
RefSeq Peptide - NP_032032
swissprot - P15655
swissprot - Q541T2
swissprot - Q925A1
swissprot - Q925A2
swissprot - Q925A3
Ensembl - ENSMUSG00000037225
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fgf2ENSDARG00000104348Danio rerio
 FGF2ENSGALG00000011835Gallus gallus
 FGF2ENSG00000138685Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fgf1 / P61148 / Fibroblast growth factor 1 / P05230*ENSMUSG0000003658553


Protein motifs (from Interpro)
Interpro ID Name
 IPR002209  Fibroblast growth factor family
 IPR008996  Cytokine IL1/FGF
 IPR028223  Fibroblast growth factor 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000186 activation of MAPKK activity IDA
 biological_processGO:0001525 angiogenesis IGI
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis ISS
 biological_processGO:0001759 organ induction IDA
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation ISO
 biological_processGO:0002042 cell migration involved in sprouting angiogenesis ISO
 biological_processGO:0006661 phosphatidylinositol biosynthetic process ISO
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IGI
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0009792 embryo development ending in birth or egg hatching IEA
 biological_processGO:0010001 glial cell differentiation IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IDA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0010764 negative regulation of fibroblast migration ISO
 biological_processGO:0010863 positive regulation of phospholipase C activity ISO
 biological_processGO:0014843 growth factor dependent regulation of skeletal muscle satellite cell proliferation ISO
 biological_processGO:0021762 substantia nigra development IMP
 biological_processGO:0021940 positive regulation of cerebellar granule cell precursor proliferation IDA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030214 hyaluronan catabolic process ISO
 biological_processGO:0030324 lung development IGI
 biological_processGO:0032958 inositol phosphate biosynthetic process ISO
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0042660 positive regulation of cell fate specification ISO
 biological_processGO:0043406 positive regulation of MAP kinase activity ISO
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration ISS
 biological_processGO:0043537 negative regulation of blood vessel endothelial cell migration ISO
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity ISO
 biological_processGO:0045597 positive regulation of cell differentiation IDA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IGI
 biological_processGO:0045766 positive regulation of angiogenesis ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0046668 regulation of retinal cell programmed cell death IDA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0048678 response to axon injury IMP
 biological_processGO:0048864 stem cell development IMP
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IDA
 biological_processGO:0050918 positive chemotaxis IEA
 biological_processGO:0051209 release of sequestered calcium ion into cytosol ISO
 biological_processGO:0051726 regulation of cell cycle IDA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IDA
 biological_processGO:0060038 cardiac muscle cell proliferation TAS
 biological_processGO:0060045 positive regulation of cardiac muscle cell proliferation IEA
 biological_processGO:0060128 corticotropin hormone secreting cell differentiation IDA
 biological_processGO:0060129 thyroid-stimulating hormone-secreting cell differentiation IDA
 biological_processGO:0060548 negative regulation of cell death ISS
 biological_processGO:0060591 chondroblast differentiation ISO
 biological_processGO:0060644 mammary gland epithelial cell differentiation IDA
 biological_processGO:0060978 angiogenesis involved in coronary vascular morphogenesis IEA
 biological_processGO:0061045 negative regulation of wound healing ISO
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0090050 positive regulation of cell migration involved in sprouting angiogenesis ISS
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IDA
 biological_processGO:1903672 positive regulation of sprouting angiogenesis ISS
 biological_processGO:2000544 regulation of endothelial cell chemotaxis to fibroblast growth factor ISO
 biological_processGO:2000546 positive regulation of endothelial cell chemotaxis to fibroblast growth factor ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0005125 cytokine activity ISO
 molecular_functionGO:0005178 integrin binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity ISO
 molecular_functionGO:0042056 chemoattractant activity ISO
 molecular_functionGO:0090722 receptor-receptor interaction ISO


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
FGFR4 ligand binding and activation
FGFR1b ligand binding and activation
FGFR3c ligand binding and activation
FGFR1c ligand binding and activation
FGFR2c ligand binding and activation
FGFR2b ligand binding and activation
Syndecan interactions
Non-integrin membrane-ECM interactions
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
Downstream signaling of activated FGFR1
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
FGFRL1 modulation of FGFR1 signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Mtmr2tm1Abol/Mtmr2tm1Abol,Tg(Mpz-cre)26Mes/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Admtm1Unc/Adm+,Tg(Alb1-Ren)2Unc/?
Genetic Background: 129S6/SvEvTac-Admtm1Unc Tg(Alb1-Ren)2Unc

 MP:0000752 dystrophic muscle "progressive weakness and wasting of muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67994]
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Allelic Composition: Dmdmdx/?,Fgf2tm1Zllr/Fgf2tm1Zllr,Fgf6tm1Thbr/Fgf6tm1Thbr
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * C57BL/10ScSn

Allelic Composition: Dmdmdx/?,Fgf2tm1Zllr/Fgf2tm1Zllr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/10ScSn

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dmdmdx/?,Fgf2tm1Zllr/Fgf2tm1Zllr,Fgf6tm1Thbr/Fgf6tm1Thbr
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * C57BL/10ScSn

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Six3tm2Gco/Six3tm2.1Gco,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0000789 thickened cerebral cortex "Increased depth of the mantle coveringthe surface of the cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:49481]
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Allelic Composition: Otx2tm1Sla/Otx2tm1Sla
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000790 abnormal stratification in cerebral cortex "abnormal formation or pattern of the layers of the cerebral cortex " [J:64289, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Otx2tm1Sla/Otx2tm1Sla
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Fgf2tm1Zllr/Fgf2tm1Zllr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000798 abnormal frontal lobe morphology "malformation or absence of the anterior part of the cerebral hemisphere" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Otx2tm1Sla/Otx2tm1Sla
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgf10tm1b(EUCOMM)Wtsi/Fgf10+
Genetic Background: C57BL/6N-Fgf10tm1b(EUCOMM)Wtsi/H

 MP:0001501 abnormal sleep pattern "deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Thrbtm4Few/Thrbtm4Few
Genetic Background: involves: 129 * C57BL/6

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Fgf10tm1b(EUCOMM)Wtsi/Fgf10+
Genetic Background: C57BL/6N-Fgf10tm1b(EUCOMM)Wtsi/H

 MP:0001596 hypotension "sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Six3tm2Gco/Six3tm2.1Gco,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgf2tm1Bas/Fgf2tm1Bas
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Fgf2tm1Bee/Fgf2+,Tg(Tyrp1-TAg)3434Bee/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd79atm3Cgn/Cd79atm3Cgn,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: C57BL/6 * CBA

 MP:0002397 abnormal bone marrow morphology "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mtmr2tm1Abol/Mtmr2tm1Abol,Tg(Mpz-cre)26Mes/0
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Otx2tm1Sla/Otx2tm1Sla
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002414 abnormal myeloblast morphology/development "anomalous structure, formation, or numbers of the cells found in the bone marrow that give rise to the granulocyte line of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Otx2tm1Sla/Otx2tm1Sla
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002740 heart hypoplasia "decreased cell number in the heart" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:77765]
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Allelic Composition: Fgf2tm1Doe/Fgf2tm1Doe,Fgf9tm1Dor/Fgf9tm1Dor
Genetic Background: involves: C57BL/6J

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Thrbtm4Few/Thrbtm4Few
Genetic Background: involves: 129 * C57BL/6

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
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Allelic Composition: Otx2tm1Sla/Otx2tm1Sla
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Fgf1tm1Bas/Fgf1tm1Bas,Fgf2tm1Bas/Fgf2tm1Bas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003026 decreased vascular smooth muscle contraction "reduced ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Thrbtm4Few/Thrbtm4Few
Genetic Background: involves: 129 * C57BL/6

 MP:0003037 increased infarction size "increased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Admtm1Unc/Adm+,Tg(Alb1-Ren)2Unc/?
Genetic Background: 129S6/SvEvTac-Admtm1Unc Tg(Alb1-Ren)2Unc

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dmdmdx/?,Fgf2tm1Zllr/Fgf2tm1Zllr,Fgf6tm1Thbr/Fgf6tm1Thbr
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * C57BL/10ScSn

 MP:0003091 abnormal cell migration "defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fgf2tm1Zllr/Fgf2tm1Zllr,Fgf6tm1Thbr/Fgf6tm1Thbr
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Thrbtm4Few/Thrbtm4Few
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fgf2tm2Doe/Fgf2tm2Doe
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0003241 loss of cortex neurons "loss of neurons in the cortex region of the brain, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
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Allelic Composition: Fgf2tm1Zllr/Fgf2tm1Zllr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003248 loss of glutamate neurons "loss of the neurons that utilize glutamate as a neurotransmitter, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
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Allelic Composition: Thrbtm4Few/Thrbtm4Few
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fgf2tm1Bas/Fgf2tm1Bas
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0003544 abnormal vascular endothelial cell migration "anomaly in the movement of endothelial cell or their precursors to the appropriate location in the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95387]
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Allelic Composition: Admtm1Unc/Adm+,Tg(Alb1-Ren)2Unc/?
Genetic Background: 129S6/SvEvTac-Admtm1Unc Tg(Alb1-Ren)2Unc

 MP:0003822 decreased left ventricle systolic pressure "decrease in the pressure in the left ventricle as the heart contracts and pumps blood into the arteries" [RGD:Rat Genome Database submission]
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Allelic Composition: Thrbtm4Few/Thrbtm4Few
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fgf2tm2Doe/Fgf2tm2Doe
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0003824 decreased left ventricular developed pressure "decrease in the difference between left ventricular systolic and diastolic pressures" [RGD:Rat Genome Database submission]
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Allelic Composition: Thrbtm4Few/Thrbtm4Few
Genetic Background: involves: 129 * C57BL/6

 MP:0003833 decreased number of satellite cells "less than the normal number of unfused cells in muscle that play a role in muscle regeneration" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Dmdmdx/?,Fgf2tm1Zllr/Fgf2tm1Zllr,Fgf6tm1Thbr/Fgf6tm1Thbr
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * C57BL/10ScSn

 MP:0004084 abnormal cardiac muscle relaxation "altered ability of the cardiac/heart muscle to lengthen following contractions, often measured by dP/dt min" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Thrbtm4Few/Thrbtm4Few
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fgf2tm2Doe/Fgf2tm2Doe
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0004174 abnormal spine curvature "deviation from the typical S-shape of the spine" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Dmdmdx/?,Fgf2tm1Zllr/Fgf2tm1Zllr,Fgf6tm1Thbr/Fgf6tm1Thbr
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * C57BL/10ScSn

 MP:0004184 abnormal baroreceptor physiology "anomaly in the function of the sensory nerve endings found in the wall of the atria of the heart, vena cava, aortic arch and carotid sinus that are sensitive to changes in blood pressure" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Fgf2tm1Zllr/Fgf2tm1Zllr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004876 decreased mean arterial blood pressure "decrease in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Thrbtm4Few/Thrbtm4Few
Genetic Background: involves: 129 * C57BL/6

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Thrbtm4Few/Thrbtm4Few
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fgf2tm2Doe/Fgf2tm2Doe
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Thrbtm4Few/Thrbtm4Few
Genetic Background: involves: 129 * C57BL/6

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fgf2tm1Zllr/Fgf2tm1Zllr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
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Allelic Composition: Fgf2tm1Zllr/Fgf2tm1Zllr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Thrbtm4Few/Thrbtm4Few
Genetic Background: involves: 129 * C57BL/6

 MP:0008221 abnormal hippocampal commissure morphology "any structural anomaly of the triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Fgf2tm1Zllr/Fgf2tm1Zllr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008503 abnormal spinal cord gray matter morphology "any structural anomaly of the regions of the spinal cord that are largely or entirely composed of nerve cell bodies and their dendrites and some supportive tissue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgf2tm1Zllr/Fgf2tm1Zllr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008547 abnormal neocortex morphology "any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.885.213.420]
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Allelic Composition: Fgf1tm1Bas/Fgf1tm1Bas,Fgf2tm1Bas/Fgf2tm1Bas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008725 enlarged heart atrium "increased size of one or both of the two upper chambers of the heart, to which the blood returns from the circulation" [MESH:A07.541.358]
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Allelic Composition: Fgf2tm1Doe/Fgf2tm1Doe,Fgf9tm1Dor/Fgf9tm1Dor
Genetic Background: involves: C57BL/6J

 MP:0009403 increased variability of skeletal muscle fiber size "greater range or dispersion within a distribution of skeletal muscle fiber size within a muscle compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dmdmdx/?,Fgf2tm1Zllr/Fgf2tm1Zllr,Fgf6tm1Thbr/Fgf6tm1Thbr
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * C57BL/10ScSn

 MP:0009414 skeletal muscle fiber necrosis "pathological cell death in the skeletal muscle fibers, usually due to irreversible damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dmdmdx/?,Fgf2tm1Zllr/Fgf2tm1Zllr,Fgf6tm1Thbr/Fgf6tm1Thbr
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * C57BL/10ScSn

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Thrbtm4Few/Thrbtm4Few
Genetic Background: involves: 129 * C57BL/6

 MP:0009969 abnormal cerebral cortex pyramidal cell morphology "any structural anomaly of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Thrbtm4Few/Thrbtm4Few
Genetic Background: involves: 129 * C57BL/6

 MP:0009974 decreased cerebral cortex pyramidal cell number "reduced number of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Thrbtm4Few/Thrbtm4Few
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fgf2tm1Zllr/Fgf2tm1Zllr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgf2tm2Doe/Fgf2tm2Doe
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0010295 increased eye tumor incidence "greater than the expected number of tumors originating in the eye in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgf2tm1Bas/Fgf2tm1Bas
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000048373 Fgfbp1 / O70514 / Fibroblast growth factor-binding protein 1 / Q14512*  / complex / reaction






 

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