ENSG00000140285


Homo sapiens

Features
Gene ID: ENSG00000140285
  
Biological name :FGF7
  
Synonyms : FGF7 / fibroblast growth factor 7 / P21781
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q21.2
Gene start: 49423096
Gene end: 49488775
  
Corresponding Affymetrix probe sets: 1554741_s_at (Human Genome U133 Plus 2.0 Array)   1555102_at (Human Genome U133 Plus 2.0 Array)   1555103_s_at (Human Genome U133 Plus 2.0 Array)   205782_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000478148
Ensembl peptide - ENSP00000267843
Ensembl peptide - ENSP00000453048
Ensembl peptide - ENSP00000453980
Ensembl peptide - ENSP00000454205
NCBI entrez gene - 2252     See in Manteia.
OMIM - 148180
RefSeq - NM_002009
RefSeq Peptide - NP_002000
swissprot - H0YNE7
swissprot - P21781
Ensembl - ENSG00000140285
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fgf7ENSDARG00000059387Danio rerio
 FGF7ENSGALG00000028158Gallus gallus
 Fgf7ENSMUSG00000027208Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FGF10 / O15520 / fibroblast growth factor 10ENSG0000007019349
FGF22 / Q9HCT0 / fibroblast growth factor 22ENSG0000007038836
FGF3 / P11487 / fibroblast growth factor 3ENSG0000018689535
FGF20 / Q9NP95 / fibroblast growth factor 20ENSG0000007857935
FGF16 / O43320 / fibroblast growth factor 16ENSG0000019646832
FGF5 / P12034 / fibroblast growth factor 5ENSG0000013867532
FGF9 / P31371 / fibroblast growth factor 9ENSG0000010267831
FGF6 / P10767 / fibroblast growth factor 6ENSG0000011124128
FGF4 / P08620 / fibroblast growth factor 4ENSG0000007538828
FGF13 / Q92913 / fibroblast growth factor 13ENSG0000012968226
FGF11 / Q92914 / fibroblast growth factor 11ENSG0000016195825
FGF14 / Q92915 / fibroblast growth factor 14ENSG0000010246625
FGF12 / P61328 / fibroblast growth factor 12ENSG0000011427924


Protein motifs (from Interpro)
Interpro ID Name
 IPR002209  Fibroblast growth factor family
 IPR008996  Cytokine IL1/FGF
 IPR028247  Fibroblast growth factor 7


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0007165 signal transduction NAS
 biological_processGO:0008284 positive regulation of cell proliferation IGI
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IGI
 biological_processGO:0008544 epidermis development TAS
 biological_processGO:0009611 response to wounding TAS
 biological_processGO:0010463 mesenchymal cell proliferation IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010838 positive regulation of keratinocyte proliferation IDA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0031069 hair follicle morphogenesis IEA
 biological_processGO:0031532 actin cytoskeleton reorganization IDA
 biological_processGO:0034394 protein localization to cell surface IDA
 biological_processGO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IDA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0050918 positive chemotaxis IDA
 biological_processGO:0051549 positive regulation of keratinocyte migration IDA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling TAS
 biological_processGO:0060445 branching involved in salivary gland morphogenesis IEA
 biological_processGO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis IDA
 biological_processGO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling IEA
 biological_processGO:0061033 secretion by lung epithelial cell involved in lung growth IDA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005794 Golgi apparatus IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity TAS
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0016303 1-phosphatidylinositol-3-kinase activity TAS
 molecular_functionGO:0042056 chemoattractant activity IDA
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
FGFR2b ligand binding and activation
Activated point mutants of FGFR2
Constitutive Signaling by Aberrant PI3K in Cancer
Phospholipase C-mediated cascade; FGFR2
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
Negative regulation of FGFR2 signaling
Signaling by FGFR2 in disease
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000137440 FGFBP1 / Q14512 / fibroblast growth factor binding protein 1  / complex / reaction
 ENSG00000066468 FGFR2 / P21802 / fibroblast growth factor receptor 2  / reaction / complex






 

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