ENSG00000152214


Homo sapiens

Features
Gene ID: ENSG00000152214
  
Biological name :RIT2
  
Synonyms : Q99578 / Ras like without CAAX 2 / RIT2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 18
Strand: -1
Band: q12.3
Gene start: 42743227
Gene end: 43115691
  
Corresponding Affymetrix probe sets: 206984_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000466620
Ensembl peptide - ENSP00000321805
Ensembl peptide - ENSP00000467217
NCBI entrez gene - 6014     See in Manteia.
OMIM - 609592
RefSeq - NM_002930
RefSeq - NM_001272077
RefSeq Peptide - NP_001259006
RefSeq Peptide - NP_002921
swissprot - Q99578
swissprot - K7EMR8
Ensembl - ENSG00000152214
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RIT2ENSGALG00000033353Gallus gallus
 Rit2ENSMUSG00000057455Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RIT1 / Q92963 / Ras like without CAAX 1ENSG0000014362267
RAP1A / P62834 / RAP1A, member of RAS oncogene familyENSG0000011647340
RAP1B / P61224 / RAP1B, member of RAS oncogene familyENSG0000012731439
RAP2A / P10114 / RAP2A, member of RAS oncogene familyENSG0000012524937
RAP2C / Q9Y3L5 / RAP2C, member of RAS oncogene familyENSG0000012372837
RAP2B / P61225 / RAP2B, member of RAS oncogene familyENSG0000018146736
DIRAS1 / O95057 / DIRAS family GTPase 1ENSG0000017649033
RASD2 / Q96D21 / RASD family member 2ENSG0000010030233
DIRAS2 / Q96HU8 / DIRAS family GTPase 2ENSG0000016502331
RASD1 / Q9Y272 / ras related dexamethasone induced 1ENSG0000010855129
DIRAS3 / O95661 / DIRAS family GTPase 3ENSG0000016259526
Q96S79 / RASL10B / RAS like family 10 member BENSG0000027088524
Q92737 / RASL10A / RAS like family 10 member AENSG0000010027621


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR020849  Small GTPase superfamily, Ras-type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007264 small GTPase mediated signal transduction NAS
 biological_processGO:0007265 Ras protein signal transduction ISS
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0010976 positive regulation of neuron projection development ISS
 biological_processGO:0010977 negative regulation of neuron projection development IEA
 biological_processGO:0030100 regulation of endocytosis IMP
 biological_processGO:0032489 regulation of Cdc42 protein signal transduction ISS
 biological_processGO:0032507 maintenance of protein location in cell IMP
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0043410 positive regulation of MAPK cascade ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050848 regulation of calcium-mediated signaling ISS
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0044297 cell body ISS
 cellular_componentGO:0045121 membrane raft IDA
 cellular_componentGO:0097447 dendritic tree ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding ISS
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0030215 semaphorin receptor binding IPI


Pathways (from Reactome)
Pathway description
Signalling to p38 via RIT and RIN


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000134259 NGF / P01138 / nerve growth factor  / complex / reaction
 ENSG00000157764 BRAF / P15056 / B-Raf proto-oncogene, serine/threonine kinase  / reaction / complex
 ENSG00000198400 NTRK1 / P04629 / neurotrophic receptor tyrosine kinase 1  / reaction / complex






 

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