ENSG00000123728


Homo sapiens

Features
Gene ID: ENSG00000123728
  
Biological name :RAP2C
  
Synonyms : Q9Y3L5 / RAP2C / RAP2C, member of RAS oncogene family
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: -1
Band: q26.2
Gene start: 132203024
Gene end: 132219480
  
Corresponding Affymetrix probe sets: 218668_s_at (Human Genome U133 Plus 2.0 Array)   218669_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000484870
Ensembl peptide - ENSP00000340274
Ensembl peptide - ENSP00000359911
NCBI entrez gene - 57826     See in Manteia.
RefSeq - XM_011531376
RefSeq - NM_001271186
RefSeq - NM_001271187
RefSeq - NM_021183
RefSeq - XM_006724775
RefSeq Peptide - NP_001258116
RefSeq Peptide - NP_067006
RefSeq Peptide - NP_001258115
swissprot - Q9Y3L5
swissprot - A0A087X2C3
Ensembl - ENSG00000123728
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rap2cENSDARG00000015649Danio rerio
 Rap2cENSMUSG00000050029Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RAP2A / P10114 / RAP2A, member of RAS oncogene familyENSG0000012524991
RAP2B / P61225 / RAP2B, member of RAS oncogene familyENSG0000018146786
RAP1A / P62834 / RAP1A, member of RAS oncogene familyENSG0000011647362
RAP1B / P61224 / RAP1B, member of RAS oncogene familyENSG0000012731461
DIRAS2 / Q96HU8 / DIRAS family GTPase 2ENSG0000016502349
DIRAS1 / O95057 / DIRAS family GTPase 1ENSG0000017649046
RIT1 / Q92963 / Ras like without CAAX 1ENSG0000014362245
RIT2 / Q99578 / Ras like without CAAX 2ENSG0000015221444
RASD1 / Q9Y272 / ras related dexamethasone induced 1ENSG0000010855139
RASD2 / Q96D21 / RASD family member 2ENSG0000010030238
DIRAS3 / O95661 / DIRAS family GTPase 3ENSG0000016259533
Q96S79 / RASL10B / RAS like family 10 member BENSG0000027088531
Q92737 / RASL10A / RAS like family 10 member AENSG0000010027630


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR020849  Small GTPase superfamily, Ras-type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0030336 negative regulation of cell migration ISS
 biological_processGO:0031954 positive regulation of protein autophosphorylation ISS
 biological_processGO:0032486 Rap protein signal transduction ISS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0061097 regulation of protein tyrosine kinase activity ISS
 biological_processGO:0090557 establishment of endothelial intestinal barrier IMP
 biological_processGO:1903506 regulation of nucleic acid-templated transcription IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005923 bicellular tight junction IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0044291 cell-cell contact zone IDA
 cellular_componentGO:0055037 recycling endosome IEA
 cellular_componentGO:0055038 recycling endosome membrane ISS
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0070821 tertiary granule membrane TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003713 transcription coactivator activity IDA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019003 GDP binding IDA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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