ENSG00000125249


Homo sapiens

Features
Gene ID: ENSG00000125249
  
Biological name :RAP2A
  
Synonyms : P10114 / RAP2A / RAP2A, member of RAS oncogene family
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: 1
Band: q32.1
Gene start: 97434222
Gene end: 97469128
  
Corresponding Affymetrix probe sets: 1556808_at (Human Genome U133 Plus 2.0 Array)   1556809_a_at (Human Genome U133 Plus 2.0 Array)   214103_s_at (Human Genome U133 Plus 2.0 Array)   214487_s_at (Human Genome U133 Plus 2.0 Array)   221830_at (Human Genome U133 Plus 2.0 Array)   225585_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000245304
Ensembl peptide - ENSP00000436462
NCBI entrez gene - 5911     See in Manteia.
OMIM - 179540
RefSeq - NM_021033
RefSeq Peptide - NP_066361
swissprot - P10114
swissprot - F6U784
Ensembl - ENSG00000125249
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RAP2AENSGALG00000016889Gallus gallus
 Rap2aENSMUSG00000051615Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RAP2B / P61225 / RAP2B, member of RAS oncogene familyENSG0000018146791
RAP2C / Q9Y3L5 / RAP2C, member of RAS oncogene familyENSG0000012372891
RAP1A / P62834 / RAP1A, member of RAS oncogene familyENSG0000011647362
RAP1B / P61224 / RAP1B, member of RAS oncogene familyENSG0000012731461
DIRAS2 / Q96HU8 / DIRAS family GTPase 2ENSG0000016502348
RIT1 / Q92963 / Ras like without CAAX 1ENSG0000014362246
DIRAS1 / O95057 / DIRAS family GTPase 1ENSG0000017649046
RIT2 / Q99578 / Ras like without CAAX 2ENSG0000015221444
RASD2 / Q96D21 / RASD family member 2ENSG0000010030239
RASD1 / Q9Y272 / ras related dexamethasone induced 1ENSG0000010855139
DIRAS3 / O95661 / DIRAS family GTPase 3ENSG0000016259533
Q92737 / RASL10A / RAS like family 10 member AENSG0000010027631
Q96S79 / RASL10B / RAS like family 10 member BENSG0000027088531


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR020849  Small GTPase superfamily, Ras-type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0030033 microvillus assembly IMP
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0031532 actin cytoskeleton reorganization IDA
 biological_processGO:0031954 positive regulation of protein autophosphorylation IEA
 biological_processGO:0032486 Rap protein signal transduction IEA
 biological_processGO:0034613 cellular protein localization IDA
 biological_processGO:0035690 cellular response to drug IDA
 biological_processGO:0045184 establishment of protein localization IDA
 biological_processGO:0046328 regulation of JNK cascade IDA
 biological_processGO:0048814 regulation of dendrite morphogenesis IDA
 biological_processGO:0072659 protein localization to plasma membrane IMP
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0055037 recycling endosome IEA
 cellular_componentGO:0055038 recycling endosome membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IMP
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019003 GDP binding IMP


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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