ENSG00000142856


Homo sapiens

Features
Gene ID: ENSG00000142856
  
Biological name :ITGB3BP
  
Synonyms : integrin subunit beta 3 binding protein / ITGB3BP / Q13352
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p31.3
Gene start: 63440770
Gene end: 63593721
  
Corresponding Affymetrix probe sets: 205176_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000271002
Ensembl peptide - ENSP00000360133
Ensembl peptide - ENSP00000432904
NCBI entrez gene - 23421     See in Manteia.
OMIM - 605494
RefSeq - XM_017000855
RefSeq - NM_001206739
RefSeq - NM_014288
RefSeq - XM_006710515
RefSeq - XM_017000853
RefSeq - XM_017000854
RefSeq - XM_006710514
RefSeq Peptide - NP_055103
RefSeq Peptide - NP_001193668
swissprot - Q13352
Ensembl - ENSG00000142856
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q9CQ82ENSMUSG00000028549Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009601  Centromere protein R


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0007155 cell adhesion TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0034080 CENP-A containing nucleosome assembly TAS
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0000777 condensed chromosome kinetochore IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane TAS
 molecular_functionGO:0004871 obsolete signal transducer activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding TAS


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
NRIF signals cell death from the nucleus
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Deposition of new CENPA-containing nucleosomes at the centromere
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000205155 PSENEN / Q9NZ42 / presenilin enhancer gamma-secretase subunit  / reaction
 ENSG00000117362 APH1A / Q96BI3 / aph-1 homolog A, gamma-secretase subunit  / reaction
 ENSG00000138613 APH1B / Q8WW43 / aph-1 homolog B, gamma-secretase subunit  / reaction
 ENSG00000161011 Q13501 / SQSTM1 / sequestosome 1  / reaction / complex
 ENSG00000064300 NGFR / P08138 / nerve growth factor receptor  / reaction / complex
 ENSG00000134259 NGF / P01138 / nerve growth factor  / reaction / complex
 ENSG00000107643 MAPK8 / P45983 / mitogen-activated protein kinase 8  / reaction
 ENSG00000162736 NCSTN / Q92542 / nicastrin  / reaction
 ENSG00000080815 PSEN1 / P49768 / presenilin 1  / reaction
 ENSG00000175104 TRAF6 / Q9Y4K3 / TNF receptor associated factor 6  / complex / reaction
 ENSG00000143801 PSEN2 / P49810 / presenilin 2  / reaction






 

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