ENSG00000183087


Homo sapiens

Features
Gene ID: ENSG00000183087
  
Biological name :GAS6
  
Synonyms : GAS6 / growth arrest specific 6 / Q14393
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: -1
Band: q34
Gene start: 113820549
Gene end: 113864067
  
Corresponding Affymetrix probe sets: 1598_g_at (Human Genome U133 Plus 2.0 Array)   202177_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000331831
NCBI entrez gene - 2621     See in Manteia.
OMIM - 600441
RefSeq - NM_000820
RefSeq Peptide - NP_000811
swissprot - Q14393
Ensembl - ENSG00000183087
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gas6ENSDARG00000007804Danio rerio
 GAS6ENSGALG00000016820Gallus gallus
 Gas6ENSMUSG00000031451Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PROS1 / P07225 / protein SENSG0000018450041
SHBG / P04278 / sex hormone binding globulinENSG0000012921413


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000294  Gamma-carboxyglutamic acid-rich (GLA) domain
 IPR000742  EGF-like domain
 IPR001791  Laminin G domain
 IPR001881  EGF-like calcium-binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR013032  EGF-like, conserved site
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR017857  Coagulation factor-like, Gla domain superfamily
 IPR018097  EGF-like calcium-binding, conserved site
 IPR026823  Complement Clr-like EGF domain
 IPR035972  Gamma-carboxyglutamic acid-rich (GLA) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0001961 positive regulation of cytokine-mediated signaling pathway IMP
 biological_processGO:0002576 platelet degranulation TAS
 biological_processGO:0003104 positive regulation of glomerular filtration IEA
 biological_processGO:0006465 signal peptide processing TAS
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport TAS
 biological_processGO:0006909 phagocytosis IDA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007050 cell cycle arrest TAS
 biological_processGO:0007155 cell adhesion TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007167 enzyme linked receptor protein signaling pathway IEA
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0009267 cellular response to starvation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway IDA
 biological_processGO:0010934 macrophage cytokine production IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016477 cell migration TAS
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0019064 fusion of virus membrane with host plasma membrane IDA
 biological_processGO:0019079 viral genome replication IDA
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0031589 cell-substrate adhesion IEA
 biological_processGO:0032008 positive regulation of TOR signaling IEA
 biological_processGO:0032148 activation of protein kinase B activity IEA
 biological_processGO:0032689 negative regulation of interferon-gamma production IDA
 biological_processGO:0032715 negative regulation of interleukin-6 production IDA
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IDA
 biological_processGO:0032825 positive regulation of natural killer cell differentiation IDA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IDA
 biological_processGO:0033159 negative regulation of protein import into nucleus, translocation IDA
 biological_processGO:0035457 cellular response to interferon-alpha IDA
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0035754 B cell chemotaxis IDA
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0043277 apoptotic cell clearance IEA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0043491 protein kinase B signaling IEA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0045860 positive regulation of protein kinase activity IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0046718 viral entry into host cell IDA
 biological_processGO:0046813 receptor-mediated virion attachment to host cell IDA
 biological_processGO:0046827 positive regulation of protein export from nucleus IDA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IDA
 biological_processGO:0050711 negative regulation of interleukin-1 secretion IDA
 biological_processGO:0050766 positive regulation of phagocytosis IDA
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IDA
 biological_processGO:0070168 negative regulation of biomineral tissue development IDA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0070527 platelet aggregation TAS
 biological_processGO:0070588 calcium ion transmembrane transport IDA
 biological_processGO:0071307 cellular response to vitamin K IDA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:0072659 protein localization to plasma membrane IDA
 biological_processGO:0085029 extracellular matrix assembly IEA
 biological_processGO:0097028 dendritic cell differentiation IEP
 biological_processGO:0097241 hematopoietic stem cell migration to bone marrow IDA
 biological_processGO:1900142 negative regulation of oligodendrocyte apoptotic process IDA
 biological_processGO:1900165 negative regulation of interleukin-6 secretion IDA
 biological_processGO:2000270 negative regulation of fibroblast apoptotic process IDA
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process IDA
 biological_processGO:2000510 positive regulation of dendritic cell chemotaxis IDA
 biological_processGO:2000533 negative regulation of renal albumin absorption IEA
 biological_processGO:2000669 negative regulation of dendritic cell apoptotic process IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0031093 platelet alpha granule lumen TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0001786 phosphatidylserine binding IDA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005245 voltage-gated calcium channel activity IDA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030296 protein tyrosine kinase activator activity IDA
 molecular_functionGO:0030971 receptor tyrosine kinase binding IPI
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048018 receptor ligand activity IDA
 molecular_functionGO:0060090 molecular adaptor activity IDA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Gamma-carboxylation of protein precursors
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Removal of aminoterminal propeptides from gamma-carboxylated proteins
Cell surface interactions at the vascular wall
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000115486 GGCX / P38435 / gamma-glutamyl carboxylase  / reaction
 ENSG00000140564 FURIN / P09958 / furin, paired basic amino acid cleaving enzyme  / reaction
 ENSG00000153208 MERTK / Q12866 / MER proto-oncogene, tyrosine kinase  / complex / reaction






 

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