ENSMUSG00000037316


Mus musculus

Features
Gene ID: ENSMUSG00000037316
  
Biological name :Bag4
  
Synonyms : Bag4 / BAG family molecular chaperone regulator 4 / Q8CI61
  
Possible biological names infered from orthology : BCL2 associated athanogene 4 / O95429
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: A2
Gene start: 25764538
Gene end: 25785287
  
Corresponding Affymetrix probe sets: 10577858 (MoGene1.0st)   1418707_at (Mouse Genome 430 2.0 Array)   1439024_at (Mouse Genome 430 2.0 Array)   1449186_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000044725
NCBI entrez gene - 67384     See in Manteia.
MGI - MGI:1914634
RefSeq - NM_026121
RefSeq Peptide - NP_080397
swissprot - A6H6S8
swissprot - Q8CI61
Ensembl - ENSMUSG00000037316
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bag4ENSDARG00000043179Danio rerio
 BAG4ENSGALG00000003254Gallus gallus
 BAG4ENSG00000156735Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bag3 / Q9JLV1 / BAG family molecular chaperone regulator 3 / O95817* / BCL2 associated athanogene 3*ENSMUSG0000003084722
Bag5 / Q8CI32 / BAG family molecular chaperone regulator 5 / Q9UL15* / BCL2 associated athanogene 5*ENSMUSG0000004979214


Protein motifs (from Interpro)
Interpro ID Name
 IPR003103  BAG domain
 IPR036533  BAG domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process RCA
 biological_processGO:0010763 positive regulation of fibroblast migration IMP
 biological_processGO:0030838 positive regulation of actin filament polymerization IMP
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IMP
 biological_processGO:0042981 regulation of apoptotic process RCA
 biological_processGO:0045785 positive regulation of cell adhesion IMP
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:0051496 positive regulation of stress fiber assembly IMP
 biological_processGO:0051897 positive regulation of protein kinase B signaling IMP
 biological_processGO:0071356 cellular response to tumor necrosis factor ISO
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IDA
 biological_processGO:0072659 protein localization to plasma membrane IDA
 biological_processGO:0090367 negative regulation of mRNA modification IEA
 biological_processGO:0097178 ruffle assembly IMP
 biological_processGO:1903215 negative regulation of protein targeting to mitochondrion ISO
 biological_processGO:2001145 negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0051087 chaperone binding IEA


Pathways (from Reactome)
Pathway description
Regulation of HSF1-mediated heat shock response
TNF signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
Show

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gusbmps/Gusbmps
Genetic Background: involves: C57BL/6By

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Lyntm1Sor/Lyntm1Sor
Genetic Background: involves: 129S4/SvJaeSor

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024401 Tnf / P06804 / tumor necrosis factor / P01375*  / reaction
 ENSMUSG00000037316 Bag4 / Q8CI61 / BAG family molecular chaperone regulator 4 / O95429* / BCL2 associated athanogene 4*  / complex
 ENSMUSG00000030341 P25118 / Tnfrsf1a / tumor necrosis factor receptor superfamily, member 1a / P19438* / TNF receptor superfamily member 1A*  / complex






 

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