Manteia - Molecule gene

ENSMUSG00000030847

Mus musculus

Features

Gene ID:	ENSMUSG00000030847

Biological name :	Bag3

Synonyms :	Bag3 / BAG family molecular chaperone regulator 3 / Q9JLV1

Possible biological names infered from orthology :	BCL2 associated athanogene 3 / O95817

Species:	Mus musculus

Chr. number:	7
Strand:	1
Band:	F3
Gene start:	128523616
Gene end:	128546981

Corresponding Affymetrix probe sets:	10557992 (MoGene1.0st) 1422452_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000033136 NCBI entrez gene - 29810 See in Manteia. MGI - MGI:1352493 RefSeq - NM_013863 RefSeq Peptide - NP_038891 swissprot - Q9JLV1 Ensembl - ENSMUSG00000030847

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
bag3	ENSDARG00000039486	Danio rerio
BAG3	ENSGALG00000009433	Gallus gallus
BAG3	ENSG00000151929	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Bag4 / Q8CI61 / BAG family molecular chaperone regulator 4 / O95429* / BCL2 associated athanogene 4*	ENSMUSG00000037316	17
Bag5 / Q8CI32 / BAG family molecular chaperone regulator 5 / Q9UL15* / BCL2 associated athanogene 5*	ENSMUSG00000049792	11

Protein motifs (from Interpro)

Interpro ID	Name
IPR001202	WW domain
IPR003103	BAG domain
IPR036020	WW domain superfamily
IPR036533	BAG domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006915	apoptotic process	IEA
biological_process	GO:0007420	brain development	IEA
biological_process	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	IEA
biological_process	GO:0010664	negative regulation of striated muscle cell apoptotic process	IMP
biological_process	GO:0021510	spinal cord development	IEA
biological_process	GO:0034605	cellular response to heat	IEA
biological_process	GO:0042993	obsolete positive regulation of transcription factor import into nucleus	IEA
biological_process	GO:0046827	positive regulation of protein export from nucleus	IEA
biological_process	GO:0050790	regulation of catalytic activity	IEA
biological_process	GO:0050821	protein stabilization	IMP
biological_process	GO:0071260	cellular response to mechanical stimulus	IMP
biological_process	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	IDA
biological_process	GO:0097201	negative regulation of transcription from RNA polymerase II promoter in response to stress	IEA
cellular_component	GO:0005634	nucleus	ISO
cellular_component	GO:0005737	cytoplasm	ISS
cellular_component	GO:0005829	cytosol	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0030018	Z disc	IDA
cellular_component	GO:0043005	neuron projection	IEA
molecular_function	GO:0000774	adenyl-nucleotide exchange factor activity	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0045296	cadherin binding	IEA
molecular_function	GO:0051087	chaperone binding	IEA

Pathways (from Reactome)

Pathway description

Regulation of HSF1-mediated heat shock response

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000189	hypoglycemia	"low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Nek1^kat/Nek1^kat Genetic Background: involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn
MP:0000221	decreased WBC count	"fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Nek1^kat/Nek1^kat Genetic Background: involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn
MP:0000222	decreased neutrophil count	"fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nek1^kat/Nek1^kat Genetic Background: involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn
MP:0000274	enlarged heart	"increase over normal size of the heart" [J:29971]	Show Allelic Composition: Astn2^ridge/Astn2^ridge,Fzd6^tm1Nat/Fzd6^tm1Nat Genetic Background: involves: 129 * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA Allelic Composition: Bag3^{tm1c(EUCOMM)Hmgu}/Bag3^tm1.1Chen,Tg(Myhca-cre)1Abel/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N * FVB/N
MP:0000603	pale liver	"liver lacking normal coloration, often refers to bloodless condition" [J:18048]	Show Allelic Composition: Nek1^kat/Nek1^kat Genetic Background: involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn
MP:0000694	spleen hypoplasia	"small size due to reduced cell number in the spleen" [J:43971]	Show Allelic Composition: Nek1^kat/Nek1^kat Genetic Background: involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn
MP:0000745	tremors	"repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Atp6v1d^{tm1b(EUCOMM)Hmgu}/Atp6v1d^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Atp6v1d^{tm1b(EUCOMM)Hmgu}/Tcp
MP:0000759	abnormal skeletal muscle morphology	"anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Aph1c^tm1Bdes/Aph1c^tm1Bdes Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001260	increased body weight	"greater than normal average weight " [J:33400]	Show Allelic Composition: Asxl1^{tm1a(EUCOMM)Wtsi}/Asxl1⁺ Genetic Background: C57BL/6N-Asxl1^{tm1a(EUCOMM)Wtsi}/Cnrm
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Stub1^em1Schiz/Stub1^em1Schiz Genetic Background: C57BL/6J-Stub1^em1Schiz
MP:0001263	weight loss	"progressive reduction of body weight below normal average for age" [J:45400]	Show Allelic Composition: Nek1^kat/Nek1^kat Genetic Background: involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Aph1c^tm1Bdes/Aph1c^tm1Bdes Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Bag3^tm1.1Chen/Bag3^tm1.1Chen Genetic Background: B6.129(SJL)-Bag3^tm1.1Chen Allelic Composition: Bag3^{tm1b(EUCOMM)Hmgu}/Bag3^{tm1b(EUCOMM)Hmgu} Genetic Background: involves: C57BL/6N
MP:0001823	thymus hypoplasia	"small size due to reduced cell number in the thymus" [J:23255]	Show Allelic Composition: Nek1^kat/Nek1^kat Genetic Background: involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn
MP:0002082	postnatal lethality	"premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Aph1c^tm1Bdes/Aph1c^tm1Bdes Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Astn2^ridge/Astn2^ridge,Fzd6^tm1Nat/Fzd6^tm1Nat Genetic Background: involves: 129 * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA Allelic Composition: Bag3^tm1.1Chen/Bag3^tm1.1Chen Genetic Background: B6.129(SJL)-Bag3^tm1.1Chen
MP:0002427	dwarfism	"abnormally undersized with disproportionate body parts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Aph1c^tm1Bdes/Aph1c^tm1Bdes Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002575	increased circulating ketone body level	"greater than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, J:71968]	Show Allelic Composition: Nek1^kat/Nek1^kat Genetic Background: involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn
MP:0002628	fatty liver	"an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Nek1^kat/Nek1^kat Genetic Background: involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn
MP:0002644	decreased circulating triglyceride level	"lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Nek1^kat/Nek1^kat Genetic Background: involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn
MP:0002727	decreased circulating insulin level	"less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]	Show Allelic Composition: Nek1^kat/Nek1^kat Genetic Background: involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn
MP:0002795	dilated cardiomyopathy	"decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Astn2^ridge/Astn2^ridge,Fzd6^tm1Nat/Fzd6^tm1Nat Genetic Background: involves: 129 * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA Allelic Composition: Bag3^{tm1c(EUCOMM)Hmgu}/Bag3^tm1.1Chen,Tg(Myhca-cre)1Abel/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N * FVB/N
MP:0002833	increased heart weight	"greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]	Show Allelic Composition: Astn2^ridge/Astn2^ridge,Fzd6^tm1Nat/Fzd6^tm1Nat Genetic Background: involves: 129 * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA Allelic Composition: Bag3^{tm1c(EUCOMM)Hmgu}/Bag3^tm1.1Chen,Tg(Myhca-cre)1Abel/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N * FVB/N
MP:0003141	cardiac fibrosis	"formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Astn2^ridge/Astn2^ridge,Fzd6^tm1Nat/Fzd6^tm1Nat Genetic Background: involves: 129 * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA
MP:0003222	increased cardiomyocyte apoptosis	"increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]	Show Allelic Composition: Aph1c^tm1Bdes/Aph1c^tm1Bdes Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003402	decreased liver weight	"reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nek1^kat/Nek1^kat Genetic Background: involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn
MP:0003828	pulmonary edema	"an accumulation of an excessive amount of watery fluid in the lung " [J:44108, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Aph1c^tm1Bdes/Aph1c^tm1Bdes Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003961	decreased lean body mass	"less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]	Show Allelic Composition: Atp6v1d^{tm1b(EUCOMM)Hmgu}/Atp6v1d^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Atp6v1d^{tm1b(EUCOMM)Hmgu}/Tcp
MP:0004091	abnormal Z lines	"any structural abnormality in the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Aph1c^tm1Bdes/Aph1c^tm1Bdes Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004215	abnormal myocardial fiber physiology	"anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Astn2^ridge/Astn2^ridge,Fzd6^tm1Nat/Fzd6^tm1Nat Genetic Background: involves: 129 * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA
MP:0004566	myocardial fiber degeneration	"deterioration or destruction of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Aph1c^tm1Bdes/Aph1c^tm1Bdes Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004953	decreased spleen weight	"reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nek1^kat/Nek1^kat Genetic Background: involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn
MP:0004956	decreased thymus weight	"reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nek1^kat/Nek1^kat Genetic Background: involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn
MP:0005016	decreased lymphocyte number	"fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nek1^kat/Nek1^kat Genetic Background: involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn
MP:0005140	decreased cardiac muscle contractility	"inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Astn2^ridge/Astn2^ridge,Fzd6^tm1Nat/Fzd6^tm1Nat Genetic Background: involves: 129 * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA Allelic Composition: Bag3^{tm1c(EUCOMM)Hmgu}/Bag3^tm1.1Chen,Tg(Myhca-cre)1Abel/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N * FVB/N
MP:0005179	decreased total circulating cholesterol level	"less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Nek1^kat/Nek1^kat Genetic Background: involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn
MP:0006138	congestive heart failure	"the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Astn2^ridge/Astn2^ridge,Fzd6^tm1Nat/Fzd6^tm1Nat Genetic Background: involves: 129 * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA
MP:0008260	abnormal autophagy	"abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]	Show Allelic Composition: Astn2^ridge/Astn2^ridge,Fzd6^tm1Nat/Fzd6^tm1Nat Genetic Background: involves: 129 * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA Allelic Composition: Bag3^{tm1c(EUCOMM)Hmgu}/Bag3^{tm1c(EUCOMM)Hmgu},Tg(CAG-EGFP/Map1lc3b)53Nmz/0,Tg(Myhca-cre)1Abel/0 Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NCrlj * DBA/2 * FVB/N Allelic Composition: Bag3^{tm1c(EUCOMM)Hmgu}/Bag3^tm1.1Chen,Tg(Myhca-cre)1Abel/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N * FVB/N
MP:0008844	decreased subcutaneous adipose tissue amount	"reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nek1^kat/Nek1^kat Genetic Background: involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn
MP:0009283	decreased gonadal fat pad weight	"less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nek1^kat/Nek1^kat Genetic Background: involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn
MP:0009412	skeletal muscle fiber degeneration	"pathological deterioration of skeletal muscle fiber tissue, often accompanied by loss of function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Aph1c^tm1Bdes/Aph1c^tm1Bdes Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0010052	increased grip strength	"greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]	Show Allelic Composition: Asxl1^{tm1a(EUCOMM)Wtsi}/Asxl1⁺ Genetic Background: C57BL/6N-Asxl1^{tm1a(EUCOMM)Wtsi}/Cnrm
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Nek1^kat/Nek1^kat Genetic Background: involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Atp6v1d^{tm1b(EUCOMM)Hmgu}/Atp6v1d^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Atp6v1d^{tm1b(EUCOMM)Hmgu}/Tcp Allelic Composition: Bag3^{tm1b(EUCOMM)Hmgu}/Bag3^{tm1b(EUCOMM)Hmgu} Genetic Background: involves: C57BL/6N
MP:0011390	abnormal fetal cardiomyocyte physiology	"any functional anomaly of fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [MGI:csmith, PMID:17429040]	Show Allelic Composition: Astn2^ridge/Astn2^ridge,Fzd6^tm1Nat/Fzd6^tm1Nat Genetic Background: involves: 129 * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA
MP:0011925	abnormal heart echocardiography feature	"any anomaly in echocardiographic representation of systolic and diastolic function, ventricular compliance, valvular function, or interventricular septum features" [MPD:Molly]	Show Allelic Composition: Astn2^ridge/Astn2^ridge,Fzd6^tm1Nat/Fzd6^tm1Nat Genetic Background: involves: 129 * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA Allelic Composition: Bag3^{tm1c(EUCOMM)Hmgu}/Bag3^tm1.1Chen,Tg(Myhca-cre)1Abel/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N * FVB/N

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr