21926


Mus musculus (NCBI)

Features
Gene ID: 21926
  
Biological name :
  
Synonyms : DIF|TNF-a|TNF-alpha|TNFSF2|TNFalpha|Tnfa|Tnfsf1a|Tnlg1f / Tnf / tumor necrosis factor
  
Possible biological names infered from orthology :
  
Species: Mus musculus (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 1419607_at (Mouse Genome 430 2.0 Array)   
  
Cross references: RefSeq - NT_187027.1
RefSeq - 7305585
RefSeq - NC_000083.6
RefSeq - NT_187004.1
RefSeq - 518831589
RefSeq - NP_001265530.1
RefSeq - NP_038721.1
RefSeq - NT_039662.3
RefSeq - NM_001278601.1
RefSeq - NM_013693.3
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSMUSG00000024401 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000060 protein import into nucleus, translocation ISO
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0000165 MAPK cascade ISO
 biological_processGO:0000185 activation of MAPKKK activity ISO
 biological_processGO:0000187 activation of MAPK activity ISO
 biological_processGO:0001775 cell activation ISO
 biological_processGO:0001819 positive regulation of cytokine production ISO
 biological_processGO:0001932 regulation of protein phosphorylation IDA
 biological_processGO:0001934 positive regulation of protein phosphorylation ISO
 biological_processGO:0001937 negative regulation of endothelial cell proliferation IDA
 biological_processGO:0002037 negative regulation of L-glutamate import across plasma membrane ISO
 biological_processGO:0002439 chronic inflammatory response to antigenic stimulus ISO
 biological_processGO:0002740 negative regulation of cytokine secretion involved in immune response ISO
 biological_processGO:0002876 positive regulation of chronic inflammatory response to antigenic stimulus IGI
 biological_processGO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin IGI
 biological_processGO:0006006 glucose metabolic process IDA
 biological_processGO:0006915 apoptotic process ISO
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
 biological_processGO:0006952 defense response IMP
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0006955 immune response IEA
 biological_processGO:0006959 humoral immune response IMP
 biological_processGO:0007165 signal transduction ISO
 biological_processGO:0007254 JNK cascade IGI
 biological_processGO:0007275 multicellular organism development IMP
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0008284 positive regulation of cell proliferation TAS
 biological_processGO:0008285 negative regulation of cell proliferation ISO
 biological_processGO:0008625 extrinsic apoptotic signaling pathway via death domain receptors ISO
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IDA
 biological_processGO:0009615 response to virus ISO
 biological_processGO:0009887 animal organ morphogenesis IMP
 biological_processGO:0010033 response to organic substance IDA
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0010629 negative regulation of gene expression ISO
 biological_processGO:0010693 negative regulation of alkaline phosphatase activity IDA
 biological_processGO:0019722 calcium-mediated signaling ISO
 biological_processGO:0030198 extracellular matrix organization IDA
 biological_processGO:0030316 osteoclast differentiation IGI
 biological_processGO:0030730 sequestering of triglyceride ISO
 biological_processGO:0030866 cortical actin cytoskeleton organization ISO
 biological_processGO:0031334 positive regulation of protein complex assembly ISO
 biological_processGO:0031622 positive regulation of fever generation IDA
 biological_processGO:0031642 negative regulation of myelination ISO
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway ISO
 biological_processGO:0032496 response to lipopolysaccharide ISO
 biological_processGO:0032715 negative regulation of interleukin-6 production ISO
 biological_processGO:0032722 positive regulation of chemokine production ISO
 biological_processGO:0032729 positive regulation of interferon-gamma production IGI
 biological_processGO:0032741 positive regulation of interleukin-18 production ISO
 biological_processGO:0032755 positive regulation of interleukin-6 production IDA
 biological_processGO:0032757 positive regulation of interleukin-8 production ISO
 biological_processGO:0032800 receptor biosynthetic process ISO
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation ISO
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway ISO
 biological_processGO:0034116 positive regulation of heterotypic cell-cell adhesion ISO
 biological_processGO:0034138 toll-like receptor 3 signaling pathway ISO
 biological_processGO:0035509 negative regulation of myosin-light-chain-phosphatase activity ISO
 biological_processGO:0042127 regulation of cell proliferation IDA
 biological_processGO:0042742 defense response to bacterium IDA
 biological_processGO:0043065 positive regulation of apoptotic process ISO
 biological_processGO:0043068 positive regulation of programmed cell death ISO
 biological_processGO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling ISO
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
 biological_processGO:0043242 negative regulation of protein complex disassembly ISO
 biological_processGO:0043243 positive regulation of protein complex disassembly ISO
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
 biological_processGO:0043406 positive regulation of MAP kinase activity ISO
 biological_processGO:0043491 protein kinase B signaling ISO
 biological_processGO:0043507 positive regulation of JUN kinase activity ISO
 biological_processGO:0043525 positive regulation of neuron apoptotic process ISO
 biological_processGO:0044130 negative regulation of growth of symbiont in host IGI
 biological_processGO:0045071 negative regulation of viral genome replication ISO
 biological_processGO:0045080 positive regulation of chemokine biosynthetic process ISO
 biological_processGO:0045123 cellular extravasation IDA
 biological_processGO:0045416 positive regulation of interleukin-8 biosynthetic process ISO
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process ISO
 biological_processGO:0045662 negative regulation of myoblast differentiation IMP
 biological_processGO:0045668 negative regulation of osteoblast differentiation IDA
 biological_processGO:0045670 regulation of osteoclast differentiation IDA
 biological_processGO:0045672 positive regulation of osteoclast differentiation ISO
 biological_processGO:0045732 positive regulation of protein catabolic process ISO
 biological_processGO:0045760 positive regulation of action potential ISO
 biological_processGO:0045785 positive regulation of cell adhesion ISO
 biological_processGO:0045840 positive regulation of mitotic nuclear division ISO
 biological_processGO:0045860 positive regulation of protein kinase activity ISO
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISO
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 biological_processGO:0045930 negative regulation of mitotic cell cycle IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0045994 positive regulation of translational initiation by iron IDA
 biological_processGO:0046325 negative regulation of glucose import ISO
 biological_processGO:0046330 positive regulation of JNK cascade IGI
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation ISO
 biological_processGO:0050708 regulation of protein secretion IDA
 biological_processGO:0050715 positive regulation of cytokine secretion ISO
 biological_processGO:0050727 regulation of inflammatory response IDA
 biological_processGO:0050729 positive regulation of inflammatory response ISO
 biological_processGO:0050766 positive regulation of phagocytosis ISO
 biological_processGO:0050796 regulation of insulin secretion ISO
 biological_processGO:0050806 positive regulation of synaptic transmission ISO
 biological_processGO:0050830 defense response to Gram-positive bacterium IGI
 biological_processGO:0050900 leukocyte migration IDA
 biological_processGO:0050901 leukocyte tethering or rolling ISO
 biological_processGO:0050966 detection of mechanical stimulus involved in sensory perception of pain ISO
 biological_processGO:0050995 negative regulation of lipid catabolic process ISO
 biological_processGO:0051023 regulation of immunoglobulin secretion IDA
 biological_processGO:0051044 positive regulation of membrane protein ectodomain proteolysis ISO
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity ISO
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity ISO
 biological_processGO:0051222 positive regulation of protein transport ISO
 biological_processGO:0051384 response to glucocorticoid ISO
 biological_processGO:0051798 positive regulation of hair follicle development IMP
 biological_processGO:0051897 positive regulation of protein kinase B signaling IDA
 biological_processGO:0060557 positive regulation of vitamin D biosynthetic process ISO
 biological_processGO:0060559 positive regulation of calcidiol 1-monooxygenase activity ISO
 biological_processGO:0060664 epithelial cell proliferation involved in salivary gland morphogenesis IDA
 biological_processGO:0060693 regulation of branching involved in salivary gland morphogenesis IMP
 biological_processGO:0061048 negative regulation of branching involved in lung morphogenesis ISO
 biological_processGO:0070886 positive regulation of calcineurin-NFAT signaling cascade ISO
 biological_processGO:0071222 cellular response to lipopolysaccharide IDA
 biological_processGO:0071230 cellular response to amino acid stimulus IDA
 biological_processGO:0071316 cellular response to nicotine ISO
 biological_processGO:0071407 cellular response to organic cyclic compound ISO
 biological_processGO:0071803 positive regulation of podosome assembly ISO
 biological_processGO:0072577 endothelial cell apoptotic process IDA
 biological_processGO:0072659 protein localization to plasma membrane ISO
 biological_processGO:0097190 apoptotic signaling pathway IDA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway ISO
 biological_processGO:0097527 necroptotic signaling pathway ISO
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling ISO
 biological_processGO:1901671 positive regulation of superoxide dismutase activity ISO
 biological_processGO:1903140 regulation of establishment of endothelial barrier ISO
 biological_processGO:1903347 negative regulation of bicellular tight junction assembly ISO
 biological_processGO:1904707 positive regulation of vascular smooth muscle cell proliferation IDA
 biological_processGO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell ISO
 biological_processGO:1904999 positive regulation of leukocyte adhesion to arterial endothelial cell ISO
 biological_processGO:2000010 positive regulation of protein localization to cell surface ISO
 biological_processGO:2000334 positive regulation of blood microparticle formation ISO
 biological_processGO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production ISO
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process IDA
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
 cellular_componentGO:0001891 phagocytic cup IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISO
 cellular_componentGO:0030141 secretory granule TAS
 cellular_componentGO:0045121 membrane raft ISO
 cellular_componentGO:0055037 recycling endosome IDA
 molecular_functionGO:0002020 protease binding ISO
 molecular_functionGO:0005125 cytokine activity ISO
 molecular_functionGO:0005164 tumor necrosis factor receptor binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0044212 transcription regulatory region DNA binding ISO


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr