ENSMUSG00000054555


Mus musculus

Features
Gene ID: ENSMUSG00000054555
  
Biological name :Adam12
  
Synonyms : Adam12 / Disintegrin and metalloproteinase domain-containing protein 12 / Q61824
  
Possible biological names infered from orthology : ADAM metallopeptidase domain 12 / O43184
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F3
Gene start: 133883199
Gene end: 134232146
  
Corresponding Affymetrix probe sets: 10568668 (MoGene1.0st)   1421171_at (Mouse Genome 430 2.0 Array)   1421172_at (Mouse Genome 430 2.0 Array)   1453073_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114874
Ensembl peptide - ENSMUSP00000123161
Ensembl peptide - ENSMUSP00000120094
Ensembl peptide - ENSMUSP00000065213
NCBI entrez gene - 11489     See in Manteia.
MGI - MGI:105378
RefSeq - NM_007400
RefSeq Peptide - NP_031426
swissprot - D3YUK3
swissprot - F6YWH6
swissprot - D3Z117
swissprot - Q61824
Ensembl - ENSMUSG00000054555
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adam12ENSDARG00000079068Danio rerio
 ADAM12 (1 of many)ENSDARG00000116062Danio rerio
 ADAM12ENSGALG00000041255Gallus gallus
 ADAM12ENSG00000148848Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adam19 / O35674 / Disintegrin and metalloproteinase domain-containing protein 19 / Q9H013* / ADAM metallopeptidase domain 19*ENSMUSG0000001125645
Adam33 / Q923W9 / Disintegrin and metalloproteinase domain-containing protein 33 / Q9BZ11* / ADAM metallopeptidase domain 33*ENSMUSG0000002731836
Adam15 / O88839 / Disintegrin and metalloproteinase domain-containing protein 15 / Q13444* / ADAM metallopeptidase domain 15*ENSMUSG0000002804133
Adam8 / Q05910 / Disintegrin and metalloproteinase domain-containing protein 8 / P78325* / ADAM metallopeptidase domain 8*ENSMUSG0000002547330
Adam28 / Q9JLN6 / Disintegrin and metalloproteinase domain-containing protein 28 / Q9UKQ2* / ADAM metallopeptidase domain 28*ENSMUSG0000001472528
Adam22 / Q9R1V6 / Disintegrin and metalloproteinase domain-containing protein 22 / Q9P0K1* / ADAM metallopeptidase domain 22*ENSMUSG0000004053726
Adam23 / Q9R1V7 / Disintegrin and metalloproteinase domain-containing protein 23 / O75077* / ADAM metallopeptidase domain 23*ENSMUSG0000002596425
Adam11 / Q9R1V4 / Disintegrin and metalloproteinase domain-containing protein 11 / O75078* / ADAM metallopeptidase domain 11*ENSMUSG0000002092625
Adam7 / O35227 / Disintegrin and metalloproteinase domain-containing protein 7 / Q9H2U9* / ADAM metallopeptidase domain 7*ENSMUSG0000002205623


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR001762  Disintegrin domain
 IPR002870  Peptidase M12B, propeptide
 IPR006586  ADAM, cysteine-rich
 IPR018358  Disintegrin, conserved site
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR034027  Reprolysin domain, adamalysin-type
 IPR036436  Disintegrin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017124 SH3 domain binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Invadopodia formation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000285 abnormal cardiac valve morphology "malformation of the membranous folds of the heart that prevent reflux of fluid" [J:18048]
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Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000286 abnormal mitral valve morphology "malformation of the valve between the left atrium and the left ventricle of the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam17tm1Imx/Adam17tm1Imx,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fn1tm1Ksek/Fn1tm1Ksek,Tg(RIP1-Tag)2Dh/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
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Allelic Composition: Fn1tm1Ksek/Fn1tm1Ksek,Tg(RIP1-Tag)2Dh/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001780 decreased brown fat amount "reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fn1tm1Ksek/Fn1tm1Ksek,Tg(RIP1-Tag)2Dh/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002058 neonatal lethality "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam17tm1Imx/Adam17tm1Imx,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002624 abnormal tricuspid valve morphology "malformation of the valve with three cusps located between the right atrium and the right ventricle of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam17tm1Imx/Adam17tm1Imx,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002746 abnormal semilunar valve morphology "malformation of the valves that gate the flow of blood from the ventricles into the aorta and pulmonary trunk" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82728]
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Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002747 abnormal aortic valve morphology "malformation of the valve between the left ventricle and the ascending aorta" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam17tm1Imx/Adam17tm1Imx,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002748 abnormal pulmonary valve morphology "malformation of the valve between the right ventricle and the pulmonary trunk" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam17tm1Imx/Adam17tm1Imx,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009408 decreased skeletal muscle fiber density "decrease in the number of skeletal muscle fibers in a given cross-sectional area of a skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fn1tm1Ksek/Fn1tm1Ksek,Tg(RIP1-Tag)2Dh/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010618 enlarged mitral valve "an increase in the total area occupied by the mitral valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010627 enlarged tricuspid valve "an increase in the total area occupied by the tricuspid valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Fn1tm1Ksek/Fn1tm1Ksek,Tg(RIP1-Tag)2Dh/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028017 Egf / P01132 / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA. / P01133* / epidermal growth factor*  / reaction
 ENSMUSG00000053617 O89032 / Sh3pxd2a / SH3 and PX domain-containing protein 2A / Q5TCZ1* / SH3 and PX domains 2A*  / reaction / complex






 

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