ENSMUSG00000025473


Mus musculus

Features
Gene ID: ENSMUSG00000025473
  
Biological name :Adam8
  
Synonyms : Adam8 / Disintegrin and metalloproteinase domain-containing protein 8 / Q05910
  
Possible biological names infered from orthology : ADAM metallopeptidase domain 8 / P78325
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F4
Gene start: 139978932
Gene end: 139992562
  
Corresponding Affymetrix probe sets: 10568873 (MoGene1.0st)   1416871_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026546
Ensembl peptide - ENSMUSP00000101684
Ensembl peptide - ENSMUSP00000117858
Ensembl peptide - ENSMUSP00000133673
NCBI entrez gene - 11501     See in Manteia.
MGI - MGI:107825
RefSeq - XM_017321934
RefSeq - NM_001291066
RefSeq - NM_007403
RefSeq - XM_006536151
RefSeq - XM_017321932
RefSeq - XM_017321933
RefSeq Peptide - NP_001277995
RefSeq Peptide - NP_031429
swissprot - G3UXF8
swissprot - Q05910
swissprot - E9Q359
swissprot - Q3U7G2
swissprot - Q3U1J7
Ensembl - ENSMUSG00000025473
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adam8aENSDARG00000001452Danio rerio
 adam8bENSDARG00000057644Danio rerio
 ADAM8ENSG00000151651Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adam28 / Q9JLN6 / Disintegrin and metalloproteinase domain-containing protein 28 / Q9UKQ2* / ADAM metallopeptidase domain 28*ENSMUSG0000001472536
Adam19 / O35674 / Disintegrin and metalloproteinase domain-containing protein 19 / Q9H013* / ADAM metallopeptidase domain 19*ENSMUSG0000001125635
Adam12 / Q61824 / Disintegrin and metalloproteinase domain-containing protein 12 / O43184* / ADAM metallopeptidase domain 12*ENSMUSG0000005455533
Adam15 / O88839 / Disintegrin and metalloproteinase domain-containing protein 15 / Q13444* / ADAM metallopeptidase domain 15*ENSMUSG0000002804131
Adam33 / Q923W9 / Disintegrin and metalloproteinase domain-containing protein 33 / Q9BZ11* / ADAM metallopeptidase domain 33*ENSMUSG0000002731831
Adam7 / O35227 / Disintegrin and metalloproteinase domain-containing protein 7 / Q9H2U9* / ADAM metallopeptidase domain 7*ENSMUSG0000002205629
Adam22 / Q9R1V6 / Disintegrin and metalloproteinase domain-containing protein 22 / Q9P0K1* / ADAM metallopeptidase domain 22*ENSMUSG0000004053726
Adam11 / Q9R1V4 / Disintegrin and metalloproteinase domain-containing protein 11 / O75078* / ADAM metallopeptidase domain 11*ENSMUSG0000002092624
Adam23 / Q9R1V7 / Disintegrin and metalloproteinase domain-containing protein 23 / O75077* / ADAM metallopeptidase domain 23*ENSMUSG0000002596423


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR001762  Disintegrin domain
 IPR002870  Peptidase M12B, propeptide
 IPR006586  ADAM, cysteine-rich
 IPR013032  EGF-like, conserved site
 IPR018358  Disintegrin, conserved site
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR034027  Reprolysin domain, adamalysin-type
 IPR036436  Disintegrin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IMP
 biological_processGO:0001525 angiogenesis IDA
 biological_processGO:0002523 leukocyte migration involved in inflammatory response IMP
 biological_processGO:0002675 positive regulation of acute inflammatory response IMP
 biological_processGO:0002693 positive regulation of cellular extravasation IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007160 cell-matrix adhesion TAS
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0022407 regulation of cell-cell adhesion IEA
 biological_processGO:0033089 positive regulation of T cell differentiation in thymus IDA
 biological_processGO:0043406 positive regulation of MAP kinase activity IDA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IDA
 biological_processGO:0043534 blood vessel endothelial cell migration NAS
 biological_processGO:0045089 positive regulation of innate immune response IDA
 biological_processGO:0045670 regulation of osteoclast differentiation NAS
 biological_processGO:0045780 positive regulation of bone resorption IMP
 biological_processGO:0045785 positive regulation of cell adhesion IDA
 biological_processGO:0048247 lymphocyte chemotaxis IDA
 biological_processGO:0048729 tissue morphogenesis TAS
 biological_processGO:0050729 positive regulation of inflammatory response IDA
 biological_processGO:0051044 positive regulation of membrane protein ectodomain proteolysis IDA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IDA
 biological_processGO:0061025 membrane fusion TAS
 biological_processGO:0070245 positive regulation of thymocyte apoptotic process IMP
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0072675 osteoclast fusion TAS
 biological_processGO:0098609 cell-cell adhesion IDA
 biological_processGO:2000309 positive regulation of tumor necrosis factor (ligand) superfamily member 11 production IMP
 biological_processGO:2000391 positive regulation of neutrophil extravasation IEA
 biological_processGO:2000399 negative regulation of thymocyte aggregation NAS
 biological_processGO:2000406 positive regulation of T cell migration IMP
 biological_processGO:2000415 positive regulation of fibronectin-dependent thymocyte migration IMP
 biological_processGO:2000418 positive regulation of eosinophil migration IMP
 cellular_componentGO:0002102 podosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032010 phagolysosome IEA
 cellular_componentGO:0032127 dense core granule membrane IEA
 cellular_componentGO:0042581 specific granule IEA
 cellular_componentGO:0070820 tertiary granule IEA
 cellular_componentGO:0071065 alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex IEA
 cellular_componentGO:0071133 alpha9-beta1 integrin-ADAM8 complex IDA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0005178 integrin binding TAS
 molecular_functionGO:0005509 calcium ion binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050839 cell adhesion molecule binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lmnatm1Gbon/Lmnatm1Gbon
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
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Allelic Composition: Phox2btm2Jbr/Phox2b+
Genetic Background: involves: 129S2/SvPas

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tsc1tm1Djk/Tsc1tm1Djk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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