ENSG00000151651


Homo sapiens

Features
Gene ID: ENSG00000151651
  
Biological name :ADAM8
  
Synonyms : ADAM8 / ADAM metallopeptidase domain 8 / P78325
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: q26.3
Gene start: 133262403
Gene end: 133276868
  
Corresponding Affymetrix probe sets: 205179_s_at (Human Genome U133 Plus 2.0 Array)   205180_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000453043
Ensembl peptide - ENSP00000453735
Ensembl peptide - ENSP00000453855
Ensembl peptide - ENSP00000452994
Ensembl peptide - ENSP00000453302
NCBI entrez gene - 101     See in Manteia.
OMIM - 602267
RefSeq - XM_017015466
RefSeq - NM_001109
RefSeq - NM_001164489
RefSeq - NM_001164490
RefSeq - XM_011539117
RefSeq - XM_017015465
RefSeq Peptide - NP_001157961
RefSeq Peptide - NP_001157962
RefSeq Peptide - NP_001100
swissprot - H0YMT6
swissprot - P78325
swissprot - H0YKZ1
Ensembl - ENSG00000151651
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adam8aENSDARG00000001452Danio rerio
 adam8bENSDARG00000057644Danio rerio
 Adam8ENSMUSG00000025473Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ADAM19 / Q9H013 / ADAM metallopeptidase domain 19ENSG0000013507435
ADAM28 / Q9UKQ2 / ADAM metallopeptidase domain 28ENSG0000004298035
ADAM12 / O43184 / ADAM metallopeptidase domain 12ENSG0000014884834
ADAM33 / Q9BZ11 / ADAM metallopeptidase domain 33ENSG0000014945133
ADAM15 / Q13444 / ADAM metallopeptidase domain 15ENSG0000014353732
ADAM7 / Q9H2U9 / ADAM metallopeptidase domain 7ENSG0000006920628
ADAM11 / O75078 / ADAM metallopeptidase domain 11ENSG0000007367026
ADAM22 / Q9P0K1 / ADAM metallopeptidase domain 22ENSG0000000827725
ADAM23 / O75077 / ADAM metallopeptidase domain 23ENSG0000011494824


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR001762  Disintegrin domain
 IPR002870  Peptidase M12B, propeptide
 IPR006586  ADAM, cysteine-rich
 IPR013032  EGF-like, conserved site
 IPR018358  Disintegrin, conserved site
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR034027  Reprolysin domain, adamalysin-type
 IPR036436  Disintegrin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis ISS
 biological_processGO:0001525 angiogenesis ISS
 biological_processGO:0002523 leukocyte migration involved in inflammatory response ISS
 biological_processGO:0002675 positive regulation of acute inflammatory response ISS
 biological_processGO:0002693 positive regulation of cellular extravasation IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006954 inflammatory response IDA
 biological_processGO:0010954 positive regulation of protein processing NAS
 biological_processGO:0022407 regulation of cell-cell adhesion IDA
 biological_processGO:0022617 extracellular matrix disassembly TAS
 biological_processGO:0033089 positive regulation of T cell differentiation in thymus ISS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043406 positive regulation of MAP kinase activity ISS
 biological_processGO:0043524 negative regulation of neuron apoptotic process ISS
 biological_processGO:0045089 positive regulation of innate immune response ISS
 biological_processGO:0045780 positive regulation of bone resorption ISS
 biological_processGO:0045785 positive regulation of cell adhesion ISS
 biological_processGO:0048247 lymphocyte chemotaxis ISS
 biological_processGO:0050714 positive regulation of protein secretion IC
 biological_processGO:0050729 positive regulation of inflammatory response IEA
 biological_processGO:0051044 positive regulation of membrane protein ectodomain proteolysis IDA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity ISS
 biological_processGO:0051897 positive regulation of protein kinase B signaling ISS
 biological_processGO:0070245 positive regulation of thymocyte apoptotic process ISS
 biological_processGO:0071456 cellular response to hypoxia IDA
 biological_processGO:0098609 cell-cell adhesion IEA
 biological_processGO:2000309 positive regulation of tumor necrosis factor (ligand) superfamily member 11 production ISS
 biological_processGO:2000391 positive regulation of neutrophil extravasation IDA
 biological_processGO:2000406 positive regulation of T cell migration IEA
 biological_processGO:2000415 positive regulation of fibronectin-dependent thymocyte migration ISS
 biological_processGO:2000418 positive regulation of eosinophil migration ISS
 cellular_componentGO:0002102 podosome IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032010 phagolysosome IDA
 cellular_componentGO:0032127 dense core granule membrane IDA
 cellular_componentGO:0035579 specific granule membrane TAS
 cellular_componentGO:0042581 specific granule IDA
 cellular_componentGO:0070820 tertiary granule IDA
 cellular_componentGO:0070821 tertiary granule membrane TAS
 cellular_componentGO:0071065 alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex IDA
 cellular_componentGO:0071133 alpha9-beta1 integrin-ADAM8 complex ISS
 cellular_componentGO:0101003 ficolin-1-rich granule membrane TAS
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity TAS
 molecular_functionGO:0005509 calcium ion binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IDA
 molecular_functionGO:0008270 zinc ion binding TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0043621 protein self-association TAS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050839 cell adhesion molecule binding IPI


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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