ENSDARG00000001452


Danio rerio

Features
Gene ID: ENSDARG00000001452
  
Biological name :adam8a
  
Synonyms : adam8a / ADAM metallopeptidase domain 8a
  
Possible biological names infered from orthology : ADAM8 / ADAM metallopeptidase domain 8 / Disintegrin and metalloproteinase domain-containing protein 8 / P78325 / Q05910
  
Species: Danio rerio
  
Chr. number: 13
Strand: 1
Band:
Gene start: 24671481
Gene end: 24679636
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000001187
NCBI entrez gene - 368917     See in Manteia.
RefSeq - NM_200637
RefSeq Peptide - NP_956931
swissprot - Q7ZYZ9
ZFIN ID - ZDB-GENE-030616-622
Ensembl - ENSDARG00000001452
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ADAM8ENSG00000151651Homo sapiens
 Adam8ENSMUSG00000025473Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
adam8b / ADAM metallopeptidase domain 8b / ADAM8* / Q05910* / P78325* / ADAM metallopeptidase domain 8* / Disintegrin and metalloproteinase domain-containing protein 8 *ENSDARG0000005764446
adam15 / ADAM metallopeptidase domain 15 / O88839* / Q13444* / Disintegrin and metalloproteinase domain-containing protein 15 *ENSDARG0000008921333
adam28 / ADAM metallopeptidase domain 28 / ADAM7* / Q9UKQ2* / O35227* / Q9H2U9* / Q9JLN6* / ADAM metallopeptidase domain 7* / Disintegrin and metalloproteinase domain-containing protein 7 *...ENSDARG0000003551433
adam12 / ADAM metallopeptidase domain 12 / O43184* / Q61824* / Disintegrin and metalloproteinase domain-containing protein 12 *ENSDARG0000007906831
adam19b / ADAM metallopeptidase domain 19b / ADAM19* / O35674* / Q9H013* / ADAM metallopeptidase domain 19* / Disintegrin and metalloproteinase domain-containing protein 19 *ENSDARG0000006754530
ADAM12 (1 of many) / ADAM metallopeptidase domain 12 / ADAM12* / O43184*ENSDARG0000011606225
adam22 / ADAM metallopeptidase domain 22 / Q9P0K1* / Q9R1V6* / Disintegrin and metalloproteinase domain-containing protein 22 *ENSDARG0000006053225
adam11 / ADAM metallopeptidase domain 11 / O75078* / Q9R1V4* / Disintegrin and metalloproteinase domain-containing protein 11 *ENSDARG0000007920422
adam23a / ADAM metallopeptidase domain 23a / ADAM23* / O75077* / Q9R1V7* / ADAM metallopeptidase domain 23* / Disintegrin and metalloproteinase domain-containing protein 23 *ENSDARG0000006232322
adam19a / ADAM metallopeptidase domain 19a / ADAM33* / Q9BZ11* / ADAM metallopeptidase domain 33*ENSDARG0000005969322
FO818722.1 / ADAM23* / O75077* / ADAM metallopeptidase domain 23*ENSDARG0000011245320


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR001762  Disintegrin domain
 IPR002870  Peptidase M12B, propeptide
 IPR006586  ADAM, cysteine-rich
 IPR013032  EGF-like, conserved site
 IPR018358  Disintegrin, conserved site
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR034027  Reprolysin domain, adamalysin-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0002020 protease binding IPI
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte increased accumulation ventral wall of dorsal aorta , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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