ENSG00000143537


Homo sapiens

Features
Gene ID: ENSG00000143537
  
Biological name :ADAM15
  
Synonyms : ADAM15 / ADAM metallopeptidase domain 15 / Q13444
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q21.3
Gene start: 155050566
Gene end: 155062775
  
Corresponding Affymetrix probe sets: 1555896_a_at (Human Genome U133 Plus 2.0 Array)   217007_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000476000
Ensembl peptide - ENSP00000271836
Ensembl peptide - ENSP00000432927
Ensembl peptide - ENSP00000434227
Ensembl peptide - ENSP00000348227
Ensembl peptide - ENSP00000349436
Ensembl peptide - ENSP00000352226
Ensembl peptide - ENSP00000353892
Ensembl peptide - ENSP00000357397
Ensembl peptide - ENSP00000357398
Ensembl peptide - ENSP00000403843
Ensembl peptide - ENSP00000432347
NCBI entrez gene - 8751     See in Manteia.
OMIM - 605548
RefSeq - NM_001261466
RefSeq - NM_001261464
RefSeq - NM_001261465
RefSeq - NM_003815
RefSeq - NM_207191
RefSeq - NM_207194
RefSeq - NM_207195
RefSeq - NM_207196
RefSeq - NM_207197
RefSeq Peptide - NP_001248393
RefSeq Peptide - NP_001248394
RefSeq Peptide - NP_001248395
RefSeq Peptide - NP_003806
RefSeq Peptide - NP_997074
RefSeq Peptide - NP_997077
RefSeq Peptide - NP_997078
RefSeq Peptide - NP_997079
RefSeq Peptide - NP_997080
swissprot - Q13444
Ensembl - ENSG00000143537
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adam15ENSDARG00000089213Danio rerio
 Adam15ENSMUSG00000028041Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ADAM33 / Q9BZ11 / ADAM metallopeptidase domain 33ENSG0000014945136
ADAM19 / Q9H013 / ADAM metallopeptidase domain 19ENSG0000013507436
ADAM12 / O43184 / ADAM metallopeptidase domain 12ENSG0000014884836
ADAM8 / P78325 / ADAM metallopeptidase domain 8ENSG0000015165130
ADAM28 / Q9UKQ2 / ADAM metallopeptidase domain 28ENSG0000004298027
ADAM11 / O75078 / ADAM metallopeptidase domain 11ENSG0000007367025
ADAM22 / Q9P0K1 / ADAM metallopeptidase domain 22ENSG0000000827725
ADAM23 / O75077 / ADAM metallopeptidase domain 23ENSG0000011494824
ADAM7 / Q9H2U9 / ADAM metallopeptidase domain 7ENSG0000006920622


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR001762  Disintegrin domain
 IPR002870  Peptidase M12B, propeptide
 IPR006586  ADAM, cysteine-rich
 IPR013032  EGF-like, conserved site
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR033605  ADAM15 peptidase
 IPR034027  Reprolysin domain, adamalysin-type
 IPR036436  Disintegrin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001953 negative regulation of cell-matrix adhesion IMP
 biological_processGO:0002418 immune response to tumor cell IDA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007160 cell-matrix adhesion TAS
 biological_processGO:0007229 integrin-mediated signaling pathway IMP
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0022617 extracellular matrix disassembly TAS
 biological_processGO:0030198 extracellular matrix organization TAS
 biological_processGO:0030308 negative regulation of cell growth IMP
 biological_processGO:0030336 negative regulation of cell migration IMP
 biological_processGO:0030574 collagen catabolic process IEA
 biological_processGO:0042246 tissue regeneration IEA
 biological_processGO:0045087 innate immune response IDA
 biological_processGO:0060317 cardiac epithelial to mesenchymal transition IEA
 biological_processGO:0070528 protein kinase C signaling IDA
 biological_processGO:1900121 negative regulation of receptor binding IMP
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005912 adherens junction IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0070062 extracellular exosome IDA
 molecular_functionGO:0004222 metalloendopeptidase activity TAS
 molecular_functionGO:0005178 integrin binding IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017124 SH3 domain binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Invadopodia formation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000107957 Q5TCZ1 / SH3PXD2A / SH3 and PX domains 2A  / complex / reaction
 ENSG00000039068 CDH1 / P12830 / cadherin 1  / reaction






 

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