MP:0000273 | overriding aorta | "congenitally mispositioned aorta where the origin straddles the ventral septum and so receives ejected blood from the right ventricle as well as the left." [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:67826] |
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Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Adam19tm1Asf/Adam19tm1Asf Genetic Background: either: B6.129P2-Adam19tm1Asf or (involves: 129P2/OlaHsd * C57BL/6J)
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MP:0000280 | thin ventricular wall | "decreased depth of the cardiac wall of the heart ventricles" [J:45302] |
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Allelic Composition: Fgf8tm1.1Mrt/Fgf8tm1.4Mrt,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129P2/OlaHsd
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MP:0000284 | double outlet right ventricle | "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826] |
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Allelic Composition: Fgf8tm1.1Mrt/Fgf8tm1.4Mrt,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl,Adam9tm1Bbl/Adam9tm1Bbl Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0000285 | abnormal cardiac valve morphology | "malformation of the membranous folds of the heart that prevent reflux of fluid" [J:18048] |
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Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl,Adam9tm1Bbl/Adam9tm1Bbl Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0000286 | abnormal mitral valve morphology | "malformation of the valve between the left atrium and the left ventricle of the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370] |
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Allelic Composition: Adam19tm1Asf/Adam19tm1Asf Genetic Background: either: B6.129P2-Adam19tm1Asf or (involves: 129P2/OlaHsd * C57BL/6J)
Allelic Composition: Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl,Adam9tm1Bbl/Adam9tm1Bbl Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
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MP:0000293 | absent myocardial trabeculae | "absence of the supporting bundles of muscular fibers lining the walls of the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Fgf8tm1.1Mrt/Fgf8tm1.4Mrt,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129P2/OlaHsd
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MP:0000297 | abnormal endocardial cushion morphology | "malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Plod3tm2.1Rmyl/Plod3tm2.1Rmyl Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0000301 | reduced size of endocardial cushions | "smaller than normal mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973] |
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Allelic Composition: Adam19tm1Asf/Adam19tm1Asf Genetic Background: either: B6.129P2-Adam19tm1Asf or (involves: 129P2/OlaHsd * C57BL/6J)
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MP:0000639 | abnormal adrenal gland morphology | "malformed endocrine glands located above the kidney responsible for hormone and epinephrine secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61190] |
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Allelic Composition: Plod3tm2.1Rmyl/Plod3tm2.1Rmyl Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0000759 | abnormal skeletal muscle morphology | "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Plod3tm2.1Rmyl/Plod3tm2.1Rmyl Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0000761 | thin diaphragm muscle | "reduced thickness of the diaphragm muscle" [MGI:CLS, J:60159] |
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Allelic Composition: Plod3tm2.1Rmyl/Plod3tm2.1Rmyl Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0001785 | edema | "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065] |
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Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0001914 | hemorrhage | "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0002624 | abnormal tricuspid valve morphology | "malformation of the valve with three cusps located between the right atrium and the right ventricle of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Adam19tm1Asf/Adam19tm1Asf Genetic Background: either: B6.129P2-Adam19tm1Asf or (involves: 129P2/OlaHsd * C57BL/6J)
Allelic Composition: Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl,Adam9tm1Bbl/Adam9tm1Bbl Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Allelic Composition: Adam15tm1Bbl/Adam15tm1Bbl,Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129X1/SvJ * C57BL/6
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MP:0002746 | abnormal semilunar valve morphology | "malformation of the valves that gate the flow of blood from the ventricles into the aorta and pulmonary trunk" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82728] |
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Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl,Adam9tm1Bbl/Adam9tm1Bbl Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0002747 | abnormal aortic valve morphology | "malformation of the valve between the left ventricle and the ascending aorta" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Adam19tm1Asf/Adam19tm1Asf Genetic Background: either: B6.129P2-Adam19tm1Asf or (involves: 129P2/OlaHsd * C57BL/6J)
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MP:0002748 | abnormal pulmonary valve morphology | "malformation of the valve between the right ventricle and the pulmonary trunk" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Adam19tm1Asf/Adam19tm1Asf Genetic Background: either: B6.129P2-Adam19tm1Asf or (involves: 129P2/OlaHsd * C57BL/6J)
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MP:0002754 | dilated right ventricle | "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Adam19tm1Asf/Adam19tm1Asf Genetic Background: either: B6.129P2-Adam19tm1Asf or (involves: 129P2/OlaHsd * C57BL/6J)
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MP:0005294 | abnormal heart ventricle morphology | "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0005329 | abnormal cardiac muscle morphology | "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Fgf8tm1.1Mrt/Fgf8tm1.4Mrt,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129P2/OlaHsd
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MP:0005592 | abnormal vascular smooth muscle morphology | "structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0006055 | abnormal vascular endothelial cell morphology | "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0006117 | aortic valve stenosis | "abnormal narrowing of the aortic valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0006126 | abnormal outflow tract development | "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0006128 | pulmonary valve stenosis | "abnormal narrowing of the pulmonary valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0008028 | pregnancy-related premature death | "death occuring before the normal life span of an organism, occuring during pregnancy, parturition or lactation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"] |
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Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0010402 | ventricular septal defect | "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540] |
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Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl,Adam9tm1Bbl/Adam9tm1Bbl Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0010403 | atrial septal defect | "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375] |
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Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0010418 | perimembraneous ventricular septal defect | "abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com] |
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Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Adam19tm1Asf/Adam19tm1Asf Genetic Background: either: B6.129P2-Adam19tm1Asf or (involves: 129P2/OlaHsd * C57BL/6J)
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MP:0010423 | heart right ventricle aneurysm | "thinning, stretching and bulging of a weakened heart right ventricular wall" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0010455 | aortopulmonary window | "a defect between the great vessels that results from failure of the conotruncal ridges to fuse resulting in an abnormal communication between the aorta and the pulmonary arteries" [http://emedicine.medscape.com] |
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Allelic Composition: Adam19tm1Asf/Adam19tm1Asf Genetic Background: either: B6.129P2-Adam19tm1Asf or (involves: 129P2/OlaHsd * C57BL/6J)
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MP:0010593 | thick aortic valve cusps | "an increase in the ratio of the aortic valve cusp thickness to the aortic wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0010594 | thick aortic valve | "an increase in the ratio of the aortic valve wall thickness to the aortic wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0010605 | thick pulmonary valve cusps | "an increase in the ratio of the pulmonary valve cusp thickness to the pulmonary artery wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0010618 | enlarged mitral valve | "an increase in the total area occupied by the mitral valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl,Adam9tm1Bbl/Adam9tm1Bbl Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl,Adam9tm1Bbl/Adam9tm1Bbl Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0010620 | thick mitral valve | |
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Allelic Composition: Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl,Adam9tm1Bbl/Adam9tm1Bbl Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
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MP:0010627 | enlarged tricuspid valve | "an increase in the total area occupied by the tricuspid valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl,Adam9tm1Bbl/Adam9tm1Bbl Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0010629 | thick tricuspid valve | |
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Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl,Adam9tm1Bbl/Adam9tm1Bbl Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Allelic Composition: Adam15tm1Bbl/Adam15tm1Bbl,Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129X1/SvJ * C57BL/6
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MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Adam19tm1Asf/Adam19tm1Asf Genetic Background: either: B6.129P2-Adam19tm1Asf or (involves: 129P2/OlaHsd * C57BL/6J)
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MP:0011090 | partial perinatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl,Adam9tm1Bbl/Adam9tm1Bbl Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0011099 | complete lethality throughout fetal growth and development | "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Fgf8tm1.1Mrt/Fgf8tm1.4Mrt,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129P2/OlaHsd
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