Manteia - Molecule gene

ENSMUSG00000053617

Mus musculus

Features

Gene ID:	ENSMUSG00000053617

Biological name :	Sh3pxd2a

Synonyms :	O89032 / SH3 and PX domain-containing protein 2A / Sh3pxd2a

Possible biological names infered from orthology :	Q5TCZ1 / SH3 and PX domains 2A

Species:	Mus musculus

Chr. number:	19
Strand:	-1
Band:	C3
Gene start:	47260174
Gene end:	47464411

Corresponding Affymetrix probe sets:	10468309 (MoGene1.0st) 10468311 (MoGene1.0st) 1422163_at (Mouse Genome 430 2.0 Array) 1428914_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000080325 Ensembl peptide - ENSMUSP00000107430 NCBI entrez gene - 14218 See in Manteia. MGI - MGI:1298393 RefSeq - XM_006526669 RefSeq - NM_001164717 RefSeq - NM_008018 RefSeq Peptide - NP_032044 RefSeq Peptide - NP_001158189 swissprot - O89032 Ensembl - ENSMUSG00000053617

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
sh3pxd2aa	ENSDARG00000060148	Danio rerio
sh3pxd2ab	ENSDARG00000061758	Danio rerio
SH3PXD2A	ENSGALG00000008293	Gallus gallus
Q5TCZ1	ENSG00000107957	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
A2AAY5 / Sh3pxd2b / SH3 and PX domain-containing protein 2B / A1X283* / SH3 and PX domains 2B*	ENSMUSG00000040711	34
Ncf1 / Q09014 / Neutrophil cytosol factor 1 / P14598* / neutrophil cytosolic factor 1*	ENSMUSG00000015950	11
Noxo1 / Q8VCM2 / NADPH oxidase organizer 1 / Q8NFA2*	ENSMUSG00000019320	7

Protein motifs (from Interpro)

Interpro ID	Name
IPR001452	SH3 domain
IPR001683	Phox homologous domain
IPR034917	SH3 and PX domain-containing protein 2A
IPR035449	SH3PXD2A, SH3 domain 3
IPR035450	SH3PXD2A, SH3 domain 1
IPR035452	SH3PXD2A, SH3 domain 2
IPR035453	SH3PXD2A, SH3 domain 4
IPR035454	SH3PXD2A, SH3 domain 5
IPR036028	SH3-like domain superfamily
IPR036871	PX domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006801	superoxide metabolic process	ISO
biological_process	GO:0043085	positive regulation of catalytic activity	IEA
biological_process	GO:0055114	oxidation-reduction process	IBA
biological_process	GO:0071800	podosome assembly	IBA
biological_process	GO:0072593	reactive oxygen species metabolic process	IMP
biological_process	GO:0072675	osteoclast fusion	ISO
cellular_component	GO:0002102	podosome	ISO
cellular_component	GO:0005737	cytoplasm	ISS
cellular_component	GO:0030054	cell junction	IEA
cellular_component	GO:0042995	cell projection	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0016176	superoxide-generating NADPH oxidase activator activity	IBA
molecular_function	GO:0035091	phosphatidylinositol binding	IBA

Pathways (from Reactome)

Pathway description

Invadopodia formation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000079	abnormal basioccipital bone morphology	"malformed basilar process of the occipital bone" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0000141	abnormal vertebral body morphology	"malformed main portion of the vertebra anterior to the vertebral canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0000186	decreased circulating HDL cholesterol level	"lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0000282	abnormal atrial septum morphology	"abnormality in the wall between the atria of the heart, usually incomplete closure " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0000284	double outlet right ventricle	"both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0000297	abnormal endocardial cushion morphology	"malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0000445	short snout	"reduced length of the anterior facial part of the muzzle" [J:53370]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0000598	abnormal liver morphology	"malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0000600	liver hypoplasia	"reduced size of liver due to decreased cell number " [J:57631]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0000602	enlarged sinusoidal spaces	"larger than normal sized cavities in the liver " [J:23170]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0000632	abnormal pineal gland morphology	"anomalous structure of the small, flattened body located in the depression between the superior colliculi and which produces melatonin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0000783	abnormal forebrain morphology	"malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0000963	fused dorsal root ganglia	"loss of DRG spacing pattern and the appearance of two or more ganglia as one " [J:62022, J:62023]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0001015	small superior cervical ganglion	"reduced size of the group of neurons that is the largest of the ganglia of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [J:23882]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0001146	abnormal testis morphology	"anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0001879	abnormal lymphatic vessel morphology	"malformation of the network of vessels which carries lymph around the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/?,Pdzrn3^tm1.1Saga/Pdzrn3^tm1.1Saga,Tg(Pdgfb-icre/ERT2)1Frut/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj
MP:0002108	abnormal muscle morphology	"abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0002135	abnormal kidney morphology	"abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0002152	abnormal brain morphology	"anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0002191	abnormal artery morphology	"malformation of the blood vessels that carry blood away from the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0002237	abnormal nasal cavity morphology	"any structural anomaly of the portion of the respiratory tract that extends from the nares to the pharynx; the nasal cavity is lined with ciliated mucosa" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0002239	abnormal nasal septum morphology	"any structural anomaly of the structure that separates the two nasal cavities " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0002243	abnormal vomeronasal organ morphology	"any structural anomaly of the specialized portion of the nasal septum that is composed of chemosensitive cells and lies anteriorly in the nasal cavity " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0002249	abnormal larynx morphology	"any structural anomaly of the most superior portion of the respiratory tract" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0002591	decreased mean corpuscular volume	"less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0002633	persistent truncus arteriosis	"complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0002746	abnormal semilunar valve morphology	"malformation of the valves that gate the flow of blood from the ventricles into the aorta and pulmonary trunk" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82728]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0002951	small thyroid gland	"reduced size of the endocrine gland located in the front and to the sides of the upper part of the trachea, and which secretes thyroid hormone and calcitonin " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0002968	increased circulating alkaline phosphatase level	"elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0003253	bile duct dilation	"abnormal distention of the bile ducts due to accumulation of fluid or bile" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0003584	bifid ureter	"cleft of the ureter into two parts or branches" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0003617	urinary bladder hypoplasia	"reduced number of cells comprising the urinary bladder, often resulting in a small size" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0003686	abnormal eye muscle morphology	"malformation of the muscles of the eye" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0003826	abnormal Mullerian duct morphology	"malformation of the transient embryonic tubes that empty into the cloaca and in the female develop into the oviducts, uterus, and vagina" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0003924	herniated diaphragm	"protrusion of abdominal contents into the thoracic cavity through the diaphragm" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0004110	transposition of great arteries	"cardiovascular malformation in which the aorta arises from the right ventricle while the pulmonary artery arises from the left ventricle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0004163	abnormal adenophysis morphology	"any malformation or absence of the anterior part of the pituitary that secretes a variety of hormones; its function is regulated by the hypothalamus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0004201	fetal growth retardation	"slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0004269	abnormal optic cup morphology	"any structural anomaly of double walled stuctured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0004463	basisphenoid bone foramen	"the presence of one or more holes in part of the base of the cranium between the basioccipital and the presphenoid, which usually ossifies separately in the embryo or in the young, and becomes a part of the sphenoid in the adult; in many animals it persists as a separate bone between the basioccipital bone and the presphenoidal bone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0004599	abnormal vertebral arch morphology	"any structural anomaly of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0004613	fusion of vertebral arches	"improper union of the dorsal part of adjacent vertebra" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0004666	absent stapedial artery	"absence of the small artery that passes through the ring of the stapes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0004678	split xiphoid process	"the appearance of an abnormal division of the posterior tip of the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/?,Pdzrn3^tm1.1Saga/Pdzrn3^tm1.1Saga,Tg(Pdgfb-icre/ERT2)1Frut/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj
MP:0005179	decreased total circulating cholesterol level	"less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0005269	abnormal occipital bone morphology	"anomalous structure of the bone at the lower, posterior part of the skull" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0006063	abnormal inferior vena cava morphology	"structural malformation in the principal vein draining blood from the lower portion of the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0006065	abnormal heart position	"the heart is displaced from the normal left-sided position and/or orientation" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0008386	absent styloid process	"absence of the slender needle-like pointed projection that runs downward and slightly forward from the base of the inferior surface of the petrous portion of the temporal bone to join the tympanic portion" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0008534	enlarged fourth ventricle	"increased size of the irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind; it is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space" [MESH:A08.186.211.276.500, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0008536	enlarged third ventricle	"increased size of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [MESH:A08.186.211.276.840, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0008922	abnormal cervical rib	"alternate location or appearance of a rare supernumerary rib commonly articulating with the seventh cervical vertebrae (above the normal first rib) but not reaching the sternum anteriorly" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0008923	thoracoschisis	"congenital fissure of the chest wall" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0009526	absent sublingual gland	"absence of the small mucin-producing salivary glands in the floor of the mouth beneath the tongue, anterior to the submandibular gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0009546	absent gastric milk in neonates	"failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/?,Pdzrn3^tm1.1Saga/Pdzrn3^tm1.1Saga,Tg(Pdgfb-icre/ERT2)1Frut/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj
MP:0009570	abnormal right lung morphology	"any structural anomaly of the organ of respiration located on the right side of the body" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0009820	abnormal liver vasculature morphology	"any structural anomaly of the blood vessel network of the bile-secreting exocrine gland" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0009890	cleft secondary palate	"congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]	Show Allelic Composition: Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/?,Pdzrn3^tm1.1Saga/Pdzrn3^tm1.1Saga,Tg(Pdgfb-icre/ERT2)1Frut/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj Allelic Composition: Sh3pxd2a^{Gt(OST445753)Lex}/Sh3pxd2a^{Gt(OST445753)Lex} Genetic Background: B6J.129S5-Sh3pxd2a^{Gt(OST445753)Lex}
MP:0009917	abnormal hyoid bone body morphology	"any structural anomaly of the main curve of the hyoid bone, from which the horns extend" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0010403	atrial septal defect	"abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0010404	ostium primum atrial septal defect	"interatrial communication (atrial septal defect) through the most anterior and inferior aspect of the atrial septum" [http://emedicine.medscape.com, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0010418	perimembraneous ventricular septal defect	"abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0010420	muscular ventricular septal defect	"abnormal communications between the two lower chambers of the heart, involving the muscular septum and often occurring as multiple communications, and includes central muscular or midmuscular, apical, or marginal communications when the defect is along the RV-septal junction; any single defect observed from the LV aspect may have several openings on the RV aspect" [http://emedicine.medscape.com]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0010433	double inlet heart left ventricle	"congenital heart defect in which both atriums are connected to the left ventricle, with a hypoplastic right ventricle often present, which may be on the opposite side of the heart to the usua" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0010439	abnormal hepatic vein morphology	"any structural anomaly of the veins that drain blood from the liver and terminate in three large openings to the inferior vena cava below the diaphragm and into smaller openings in more inferior positions" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0010484	bicuspid aortic valve	"the presence of two cusps in the aortic valve instead of three" [http://emedicine.medscape.com]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0010496	abnormal pectinate muscle morphology	"any structural anomaly of the prominent ridges of atrial myocardium located on the inner surface of most of the right atrium and both the right and left auricular regions" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0010527	bicuspid pulmonary valve	"the presence of two cusps or leaflets in the pulmonary valve instead of three" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0010530	cerebral arteriovenous malformation	"congenital vascular anomaly in the cerebrum characterized by direct communication between an artery and a vein without passing through the capillary bed" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0010572	persistent right dorsal aorta	"persistence of the right dorsal aorta after development; the right dorsal aorta normally regresses but when it persists, a double aortic arch develops; if the left dorsal aorta also regresses, a right aortic arch forms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0010595	abnormal aortic valve cusp morphology	"any structural anomaly of the three fibrous triangular components and associated flap of the aortic valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0010602	abnormal pulmonary valve cusp morphology	"any structural anomaly of the three fibrous triangular components and associated flap of the pulmonary valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0010728	fusion of atlas and occipital bones	"union of elements of the atlas and the bone at the lower, posterior part of the skull into one structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0010853	abnormal lung position or orientation	"the lung is displaced from the normal position and/or has an altered left/right orientation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0010912	herniated liver	"protrusion of any portion of the liver from its normal anatomical position" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0011088	partial neonatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Sh3pxd2a^{Gt(OST445753)Lex}/Sh3pxd2a^{Gt(OST445753)Lex} Genetic Background: B6J.129S5-Sh3pxd2a^{Gt(OST445753)Lex}
MP:0011090	partial perinatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/?,Pdzrn3^tm1.1Saga/Pdzrn3^tm1.1Saga,Tg(Pdgfb-icre/ERT2)1Frut/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj
MP:0011091	complete prenatal lethality	"death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Sh3pxd2a^{Gt(OST445753)Lex}/Sh3pxd2a^{Gt(OST445753)Lex} Genetic Background: B6J.129S5-Sh3pxd2a^{Gt(OST445753)Lex}
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0011110	partial preweaning lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/?,Pdzrn3^tm1.1Saga/Pdzrn3^tm1.1Saga,Tg(Pdgfb-icre/ERT2)1Frut/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj
MP:0011361	pelvic kidney	"an ectopic kidney located outside the renal fossa and within the pelvic cavity; pelvic kidneys may also, on occasion, occur as fused midline horseshoe kidneys" [MGI:anna]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0011493	double ureter	"two ureters open separately into the renal pelvis superiorly and drain separately into the urinary bladder or genital tract; if two ureteral buds arise from the Wolffian duct, a duplex kidney with complete ureteral duplication ensues" [http://emedicine.medscape.com/article/378075-overview, MGI:anna]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0011667	double outlet right ventricle with atrioventricular septal defect	"a form of DORV in which there is also a complete atrioventricular canal" [MGI:csmith]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0011683	dual inferior vena cava	"presence of two inferior vena cavae, often resulting from the persistence of both supracardinal veins during development; the two structures may be symmetric or asymmetric but typically join together at the renal vein" [MGI:csmith, PMID:10835118]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0013186	abnormal basilar artery morphology	"any structural anomaly of the unpaired artery that is formed by the union of the two vertebral arteries, runs forward within the skull just under the pons, divides into the two posterior cerebral arteries, and supplies the pons, cerebellum, posterior part of the cerebrum, and the inner ear" [MGI:anna]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0013818	abnormal oral cavity morphology	"any structural anomaly of the anatomical cavity at the start of the digestive tract that is enclosed by the mouth" [UBERON:0000167]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0013826	absent hypoglossal canal	"absence of the bony canal in the occipital bone through which the hypoglossal nerve emerges from the skull" [ISBN:0683400088]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0013835	absent hypoglossal nerve	"absence of the motor nerve which innervates all the intrinsic and all but one of the extrinsic muscles of the tongue" [ISBN:0-683-40008-8]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0013836	abnormal hypoglossal nerve topology	"abnormal position of the hypoglossal nerve " [MGI:csmith]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0013840	absent segment of posterior cerebral artery	"absence of a portion of one of a pair of blood vessels that supplies oxygenated blood to the posterior aspect of the brain" [UBERON:0001636]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0013845	abnormal eye muscle topology	"abnormal position of eye muscles" [MGI:csmith]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0013846	retropharyngeal edema	"accumulation of watery or serous fluid in the retropharyngeal space" [MGI:csmith]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0013847	retropleural edema	"accumulation of watery or serous fluid in the retropleural space" [MGI:csmith]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0013848	subcutaneous edema	"accumulation of watery or serous fluid in the subcutaneous region below the skin" [MGI:csmith]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0013852	abnormal Mullerian duct topology	"aberrant position of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) that empty into the cloaca and in the female develop into the oviducts, uterus, and vagina" [ISBN:0-683-40008-8]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0013855	absent celiac artery	"absence of the short, thick trunk which arises from the front of the abdominal aorta immediately below the aortic opening in the diaphragm" [ISBN:0-683-40008-8]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0013871	abnormal stapedial artery topology	"abnormal location or orientation of the small artery that passes through the ring of the stapes; while the stapedial artery is a temporary artery thought to disappear at late embryonic stage in humans, the mouse stapedial artery is complete by E13 and persists into adulthood" [MGI:Anna]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0013876	absent ductus venosus valve	"absence of the valve present on the right side of the ductus venosus at the site of the junction with the inferior vena cava" [PMID:5438957]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0013878	abnormal ductus venosus valve topology	"abnormal position of the valve present on the right side of the ductus venosus at the site of the junction with the inferior vena cava" [PMID:5438957]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0013917	persistent right 6th pharyngeal arch artery		Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0013923	small prevertebral sympathetic ganglia	"decreased size of the sympathetic ganglia located in front of the vertebral column and are associated with the major branches of the abdominal aorta; these include the celiac, aorticorenal, superior and inferior mesenteric ganglia" [ISBN:0-683-40008-8]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0013925	abnormal vascular plexus formation		Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0013930	abnormal digastric muscle connection		Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0013931	abnormal olfactory bulb position		Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0013932	fragmented Meckel s cartilage		Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0013936	abnormal thymus topology	"of the primary lymphoid organ that is required for maturation of T cells and secretion of thymosins, hormones that stimulate the development of antibodies" [MGI:csmith]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0013949	fusion of axis and occipital bones		Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0013965	abnormally deep median sulcus of tongue		Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0013967	abnormal infrahyoid muscle connection		Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0013969	reduced sympathetic cervical ganglion size		Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0013970	absent connection between subcutaneous lymph vessels and lymph sac		Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0013971	blood in lymph vessels		Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0013976	abnormal left vena cava superior connection		Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0013977	symmetric azygos veins		Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0013982	inverse situs of great intrathoracic arteries		Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0013986	abnormal vitelline vein topology	"abnormal position of the paired veins that carry blood from the yolk sac back to the embryo" [MGI:csmith]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0013996	abnormal vertebral artery origin		Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0013998	absent canalicular internal carotid artery segment		Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0013999	absent parasellar internal carotid artery		Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0014011	abnormal ovary tissue architecture		Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0014017	abnormal Wolffian duct connection	"aberrant attachment or incomplete connection of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) to the cloaca " [ISBN:0-683-40008-8]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0014019	embryo cyst		Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0014021	heterochrony		Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0020301	short tongue	"decreased length of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [GOC:NV]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000011256	Adam19 / O35674 / Disintegrin and metalloproteinase domain-containing protein 19 / Q9H013* / ADAM metallopeptidase domain 19*	/ complex / reaction
ENSMUSG00000028041	Adam15 / O88839 / Disintegrin and metalloproteinase domain-containing protein 15 / Q13444* / ADAM metallopeptidase domain 15*	/ reaction / complex
ENSMUSG00000054555	Adam12 / Q61824 / Disintegrin and metalloproteinase domain-containing protein 12 / O43184* / ADAM metallopeptidase domain 12*	/ reaction / complex

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