ENSMUSG00000040711


Mus musculus

Features
Gene ID: ENSMUSG00000040711
  
Biological name :Sh3pxd2b
  
Synonyms : A2AAY5 / SH3 and PX domain-containing protein 2B / Sh3pxd2b
  
Possible biological names infered from orthology : A1X283 / SH3 and PX domains 2B
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: A4
Gene start: 32347820
Gene end: 32428173
  
Corresponding Affymetrix probe sets: 10375065 (MoGene1.0st)   1435644_at (Mouse Genome 430 2.0 Array)   1442919_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000044276
NCBI entrez gene - 268396     See in Manteia.
MGI - MGI:2442062
RefSeq - NM_177364
RefSeq - XM_006514712
RefSeq Peptide - NP_796338
swissprot - A2AAY5
Ensembl - ENSMUSG00000040711
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sh3pxd2bENSDARG00000103251Danio rerio
 SH3PXD2BENSGALG00000002831Gallus gallus
 A1X283ENSG00000174705Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O89032 / Sh3pxd2a / SH3 and PX domain-containing protein 2A / Q5TCZ1* / SH3 and PX domains 2A*ENSMUSG0000005361742
Ncf1 / Q09014 / Neutrophil cytosol factor 1 / P14598* / neutrophil cytosolic factor 1*ENSMUSG0000001595013
Noxo1 / Q8VCM2 / NADPH oxidase organizer 1 / Q8NFA2*ENSMUSG000000193208


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR001683  Phox homologous domain
 IPR030512  SH3 and PX domain-containing protein 2B
 IPR035477  SH3PXD2B, SH3 domain 1
 IPR035478  SH3PXD2B, SH3 domain 2
 IPR035479  SH3PXD2B, SH3 domain 3
 IPR035480  SH3PXD2B, SH3 domain 4
 IPR036028  SH3-like domain superfamily
 IPR036871  PX domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0001654 eye development IMP
 biological_processGO:0002051 osteoblast fate commitment IMP
 biological_processGO:0006801 superoxide metabolic process IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0022617 extracellular matrix disassembly IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0040018 positive regulation of multicellular organism growth IMP
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0045600 positive regulation of fat cell differentiation IMP
 biological_processGO:0048705 skeletal system morphogenesis IMP
 biological_processGO:0051496 positive regulation of stress fiber assembly IMP
 biological_processGO:0055114 oxidation-reduction process IBA
 biological_processGO:0060348 bone development IMP
 biological_processGO:0060378 regulation of brood size IMP
 biological_processGO:0060612 adipose tissue development IMP
 biological_processGO:0071800 podosome assembly IMP
 biological_processGO:0072657 protein localization to membrane IEA
 biological_processGO:1904179 positive regulation of adipose tissue development IMP
 biological_processGO:1904888 cranial skeletal system development IMP
 cellular_componentGO:0002102 podosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0010314 phosphatidylinositol-5-phosphate binding IDA
 molecular_functionGO:0016176 superoxide-generating NADPH oxidase activator activity IBA
 molecular_functionGO:0032266 phosphatidylinositol-3-phosphate binding IMP
 molecular_functionGO:0035091 phosphatidylinositol binding IEA
 molecular_functionGO:0042169 SH2 domain binding IDA
 molecular_functionGO:0070273 phosphatidylinositol-4-phosphate binding IDA
 molecular_functionGO:0080025 phosphatidylinositol-3,5-bisphosphate binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000049 abnormal middle ear morphology "malformation or malfunction of any components of the tympanic cavity or its ossicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Catb/Catb
Genetic Background: B6.Cg-Catb/Anl

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Catb/Catb
Genetic Background: B6.Cg-Catb/Anl

 MP:0000074 abnormal neurocranium morphology "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: Sh3pxd2bGt(GST_1527_E5)Lex/Sh3pxd2bGt(GST_1527_E5)Lex
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000085 large anterior fontanelle "enlarged diamond-shaped membranous interval at the junction of the coronal, sagittal and metopic sutures of the cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Sh3pxd2btm1.1Arte/Sh3pxd2btm1.1Arte
Genetic Background: involves: C57BL/6NTac

 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sh3pxd2bGt(GST_1527_E5)Lex/Sh3pxd2bGt(GST_1527_E5)Lex
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000097 short maxilla "reduced length of the upper jaw bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Sh3pxd2bGt(GST_1527_E5)Lex/Sh3pxd2bGt(GST_1527_E5)Lex
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000159 abnormal xiphoid process "malformed posterior tip of the sternum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:42932]
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Allelic Composition: Sh3pxd2bGt(GST_1527_E5)Lex/Sh3pxd2bGt(GST_1527_E5)Lex
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Sh3pxd2bGt(GST_1527_E5)Lex/Sh3pxd2bGt(GST_1527_E5)Lex
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Sh3pxd2btm1.1Arte/Sh3pxd2btm1.1Arte
Genetic Background: involves: C57BL/6NTac

 MP:0000162 lordosis "anteriorly convex curvature of the spine, "saddle back" " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62022]
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Allelic Composition: Sh3pxd2bGt(GST_1527_E5)Lex/Sh3pxd2bGt(GST_1527_E5)Lex
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000277 abnormal heart shape "malformation of the form or the patterning of the heart" [J:18048]
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Allelic Composition: Sh3pxd2bGt(GST_1527_E5)Lex/Sh3pxd2bGt(GST_1527_E5)Lex
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000286 abnormal mitral valve morphology "malformation of the valve between the left atrium and the left ventricle of the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Sh3pxd2bGt(GST_1527_E5)Lex/Sh3pxd2bGt(GST_1527_E5)Lex
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: GnrhrGt(181A6)Cmhd/GnrhrGt(181A6)Cmhd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Sh3pxd2btm1.1Arte/Sh3pxd2btm1.1Arte
Genetic Background: involves: C57BL/6NTac

 MP:0000440 domed skull 
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Allelic Composition: Catb/Catb
Genetic Background: B6.Cg-Catb/Anl

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Catb/Catb
Genetic Background: B6.Cg-Catb/Anl

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Catb/Catb
Genetic Background: B6.Cg-Catb/Anl

Allelic Composition: Sh3pxd2btm1.1Arte/Sh3pxd2btm1.1Arte
Genetic Background: involves: C57BL/6NTac

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Catb/Catb
Genetic Background: B6.Cg-Catb/Anl

Allelic Composition: Sh3pxd2bGt(GST_1527_E5)Lex/Sh3pxd2bGt(GST_1527_E5)Lex
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Sh3pxd2btm1.1Arte/Sh3pxd2btm1.1Arte
Genetic Background: involves: C57BL/6NTac

 MP:0001300 ocular hypertelorism "increased distance between the eyes " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sh3pxd2bGt(GST_1527_E5)Lex/Sh3pxd2bGt(GST_1527_E5)Lex
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sh3pxd2bGt(GST_1527_E5)Lex/Sh3pxd2bGt(GST_1527_E5)Lex
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Catb/Catb
Genetic Background: B6.Cg-Catb/Anl

Allelic Composition: Sh3pxd2bGt(GST_1527_E5)Lex/Sh3pxd2bGt(GST_1527_E5)Lex
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001731 abnormal postnatal growth "anomaly in reaching a developmental stage or stages after birth" [il:Ira Lu, Mouse Genome Informatics Curator]
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Allelic Composition: Catb/Catb
Genetic Background: B6.Cg-Catb/Anl

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sh3pxd2bGt(GST_1527_E5)Lex/Sh3pxd2bGt(GST_1527_E5)Lex
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Catb/Catb
Genetic Background: B6.Cg-Catb/Anl

 MP:0001850 otitis media "middle ear inflammation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]
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Allelic Composition: Catb/Catb
Genetic Background: B6.Cg-Catb/Anl

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Catb/Catb
Genetic Background: B6.Cg-Catb/Anl

Allelic Composition: Sh3pxd2btm1.1Arte/Sh3pxd2btm1.1Arte
Genetic Background: involves: C57BL/6NTac

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Catb/Catb
Genetic Background: B6.Cg-Catb/Anl

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Catb/Catb
Genetic Background: B6.Cg-Catb/Anl

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sh3pxd2bGt(GST_1527_E5)Lex/Sh3pxd2bGt(GST_1527_E5)Lex
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002100 abnormal tooth morphology "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sh3pxd2bGt(GST_1527_E5)Lex/Sh3pxd2bGt(GST_1527_E5)Lex
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Catb/Catb
Genetic Background: B6.Cg-Catb/Anl

Allelic Composition: Sh3pxd2btm1.1Arte/Sh3pxd2btm1.1Arte
Genetic Background: involves: C57BL/6NTac

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sh3pxd2bGt(GST_1527_E5)Lex/Sh3pxd2bGt(GST_1527_E5)Lex
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002639 micrognathia "abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Sh3pxd2bGt(GST_1527_E5)Lex/Sh3pxd2bGt(GST_1527_E5)Lex
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002750 exophthalmos "protrusion of one or both eyeballs" [J:47965, il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Catb/Catb
Genetic Background: B6.Cg-Catb/Anl

Allelic Composition: Sh3pxd2btm1.1Arte/Sh3pxd2btm1.1Arte
Genetic Background: involves: C57BL/6NTac

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Sh3pxd2btm1.1Arte/Sh3pxd2btm1.1Arte
Genetic Background: involves: C57BL/6NTac

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sh3pxd2btm1.1Arte/Sh3pxd2btm1.1Arte
Genetic Background: involves: C57BL/6NTac

 MP:0003843 abnormal sagittal suture morphology "malformation of the articulation between the parietal bones" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
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Allelic Composition: Sh3pxd2bGt(GST_1527_E5)Lex/Sh3pxd2bGt(GST_1527_E5)Lex
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004471 short nasal bone "reduced length of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Sh3pxd2bGt(GST_1527_E5)Lex/Sh3pxd2bGt(GST_1527_E5)Lex
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sh3pxd2btm1.1Arte/Sh3pxd2btm1.1Arte
Genetic Background: involves: C57BL/6NTac

 MP:0005205 abnormal eye anterior chamber "anomaly of the space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Catb/Catb
Genetic Background: B6.Cg-Catb/Anl

 MP:0005258 ocular hypertension "abnormal elevation of the intraocular pressure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sh3pxd2bGt(GST_1527_E5)Lex/Sh3pxd2bGt(GST_1527_E5)Lex
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sh3pxd2bGt(GST_1527_E5)Lex/Sh3pxd2bGt(GST_1527_E5)Lex
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Sh3pxd2bGt(GST_1527_E5)Lex/Sh3pxd2bGt(GST_1527_E5)Lex
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005354 abnormal ilium morphology "structural anomaly of the broad, flaring portion of the hip bone, which is distinct at birth, but later fuses with the ischium and the pubis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47316]
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Allelic Composition: Sh3pxd2bGt(GST_1527_E5)Lex/Sh3pxd2bGt(GST_1527_E5)Lex
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0006120 mitral valve prolapse "collapse of one or more of the mitral valve cusps backward allowing blood to leak backwards, ususally the result of enlargement of one or more of the valve cusps" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Sh3pxd2bGt(GST_1527_E5)Lex/Sh3pxd2bGt(GST_1527_E5)Lex
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0006249 phthisis bulbi "small, shrunken, malformed eye usually occurs as the end result of eye disease" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Sh3pxd2bGt(GST_1527_E5)Lex/Sh3pxd2bGt(GST_1527_E5)Lex
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008525 decreased skull height "decrease in the distance between the cranial base and the upper domelike portion of the skull" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Catb/Catb
Genetic Background: B6.Cg-Catb/Anl

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sh3pxd2bGt(GST_1527_E5)Lex/Sh3pxd2bGt(GST_1527_E5)Lex
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Sh3pxd2btm1.1Arte/Sh3pxd2btm1.1Arte
Genetic Background: involves: C57BL/6NTac

 MP:0008853 decreased abdominal adipose tissue amount "reduction in amount of adipose tissue associated with internal organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sh3pxd2bGt(GST_1527_E5)Lex/Sh3pxd2bGt(GST_1527_E5)Lex
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008974 proportional dwarf "abnormally undersized with both limbs and trunk symmetrically shorter; usually due to chemical, endocrine, nutritional or nonosseous influences" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Catb/Catb
Genetic Background: B6.Cg-Catb/Anl

 MP:0009283 decreased gonadal fat pad weight "less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Sh3pxd2btm1.1Arte/Sh3pxd2btm1.1Arte
Genetic Background: involves: C57BL/6NTac

 MP:0009303 decreased renal fat pad weight 
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Allelic Composition: Sh3pxd2btm1.1Arte/Sh3pxd2btm1.1Arte
Genetic Background: involves: C57BL/6NTac

 MP:0009829 enlarged eye anterior chamber "increased size of the space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens" [MESH:A09.371.060.067, MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Catb/Catb
Genetic Background: B6.Cg-Catb/Anl

 MP:0010029 abnormal basicranium morphology "any structural anomaly of the sloping floor of the cranial cavity that is comprised of parts of the ethmoidal, occipital and sphenoid bones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Sh3pxd2bGt(GST_1527_E5)Lex/Sh3pxd2bGt(GST_1527_E5)Lex
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0010725 thin interventricular septum "decreased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sh3pxd2bGt(GST_1527_E5)Lex/Sh3pxd2bGt(GST_1527_E5)Lex
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Sh3pxd2aGt(OST445753)Lex/Sh3pxd2aGt(OST445753)Lex
Genetic Background: B6J.129S5-Sh3pxd2aGt(OST445753)Lex

 MP:0011167 abnormal adipose tissue development "anomaly in the process of the formation of the connective tissue composed of fat cells enmeshed in areolar tissue" [MESH:A10.165.114, MGI:csmith]
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Allelic Composition: Sh3pxd2btm1.1Arte/Sh3pxd2btm1.1Arte
Genetic Background: involves: C57BL/6NTac

 MP:0011174 lipodystrophy "abnormal or degenerative conditions of the body s adipose tissue resulting in bodily or focal loss and the appearance of redistribution of fat tissue; adipose tissue loss may be total, partial, or localized" [MGI:csmith]
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Allelic Composition: Sh3pxd2btm1.1Arte/Sh3pxd2btm1.1Arte
Genetic Background: involves: C57BL/6NTac

 MP:0011481 anterior iris synechia "adhesion of the iris to the cornea" [MGI:anna]
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Allelic Composition: Catb/Catb
Genetic Background: B6.Cg-Catb/Anl

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Catb/Catb
Genetic Background: B6.Cg-Catb/Anl

 MP:0014143 decreased body fat mass "decreased physical bulk or volume of fat in the whole body" [MGI:csmith]
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Allelic Composition: Sh3pxd2btm1.1Arte/Sh3pxd2btm1.1Arte
Genetic Background: involves: C57BL/6NTac

 MP:0030030 Wormian bones "presence of small extra bone segments, usually of irregular shape and variable size, arising in fontanelles and/or adjacent to or along the cranial sutures, and formed from additional and separate centers of ossification of the cranium; in humans, Wormian bones are most frequently located in the lambdoid or coronal suture, and have been seen in the fontanelles, particularly the posterior fontanelle" [https://www.kenhub.com/en/library/anatomy/accessory-bones-of-the-skull, PMID:23959948]
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Allelic Composition: Sh3pxd2bGt(GST_1527_E5)Lex/Sh3pxd2bGt(GST_1527_E5)Lex
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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