ENSGALG00000012155


Gallus gallus

Features
Gene ID: ENSGALG00000012155
  
Biological name :EGF
  
Synonyms : EGF / pro-epidermal growth factor precursor
  
Possible biological names infered from orthology : epidermal growth factor / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA. / P01132 / P01133
  
Species: Gallus gallus
  
Chr. number: 4
Strand: -1
Band:
Gene start: 58394125
Gene end: 58445817
  
Corresponding Affymetrix probe sets: Gga.17682.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000044972
Ensembl peptide - ENSGALP00000019824
NCBI entrez gene - 408035     See in Manteia.
RefSeq - XM_015276164
RefSeq - NM_001001292
RefSeq Peptide - NP_001001292
swissprot - A0A1D5NX79
swissprot - F1NEP5
Ensembl - ENSGALG00000012155
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 egfENSDARG00000052739Danio rerio
 EGFENSG00000138798Homo sapiens
 EgfENSMUSG00000028017Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NID1 / nidogen 1 / P10493* / P14543*ENSGALG0000004207914
NID2 / nidogen 2 / O88322* / Q14112*ENSGALG0000001239414


Protein motifs (from Interpro)
Interpro ID Name
 IPR000033  LDLR class B repeat
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001881  EGF-like calcium-binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR013032  EGF-like, conserved site
 IPR016317  Pro-epidermal growth factor
 IPR018097  EGF-like calcium-binding, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0002092 positive regulation of receptor internalization IEA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0021940 positive regulation of cerebellar granule cell precursor proliferation IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0042327 positive regulation of phosphorylation IEA
 biological_processGO:0043388 positive regulation of DNA binding IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0044332 Wnt signaling pathway involved in dorsal/ventral axis specification IEA
 biological_processGO:0045741 positive regulation of epidermal growth factor-activated receptor activity IEA
 biological_processGO:0045840 positive regulation of mitotic nuclear division IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0048754 branching morphogenesis of an epithelial tube IEA
 biological_processGO:0050730 regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0051048 negative regulation of secretion IEA
 biological_processGO:0060059 embryonic retina morphogenesis in camera-type eye IBA
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060749 mammary gland alveolus development IEA
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IEA
 biological_processGO:0070371 ERK1 and ERK2 cascade IEA
 biological_processGO:0090279 regulation of calcium ion import IEA
 biological_processGO:0090370 negative regulation of cholesterol efflux IEA
 biological_processGO:1900127 positive regulation of hyaluronan biosynthetic process IEA
 biological_processGO:2000008 regulation of protein localization to cell surface IEA
 biological_processGO:2000060 positive regulation of ubiquitin-dependent protein catabolic process IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex IEA
 cellular_componentGO:0070062 extracellular exosome IEA
 molecular_functionGO:0005154 epidermal growth factor receptor binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0017147 Wnt-protein binding IBA
 molecular_functionGO:0042813 Wnt-activated receptor activity IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Signaling by ERBB2
Signaling by ERBB4
SHC1 events in ERBB2 signaling
PIP3 activates AKT signaling
Signaling by EGFR
GRB2 events in EGFR signaling
GAB1 signalosome
SHC1 events in EGFR signaling
EGFR downregulation
PI3K events in ERBB2 signaling
EGFR interacts with phospholipase C-gamma
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Downregulation of ERBB2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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