ENSDARG00000000861


Danio rerio

Features
Gene ID: ENSDARG00000000861
  
Biological name :scrib
  
Synonyms : Q4H4B6 / scrib / scribbled planar cell polarity protein
  
Possible biological names infered from orthology : Q14160 / Q80U72
  
Species: Danio rerio
  
Chr. number: 7
Strand: 1
Band:
Gene start: 41160225
Gene end: 41275897
  
Corresponding Affymetrix probe sets: DrAffx.2.43.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000068701
Ensembl peptide - ENSDARP00000143155
Ensembl peptide - ENSDARP00000143072
Ensembl peptide - ENSDARP00000142912
Ensembl peptide - ENSDARP00000140814
NCBI entrez gene - 368473     See in Manteia.
RefSeq - NM_001007175
RefSeq Peptide - NP_001007176
swissprot - A0A1D5NSU4
swissprot - A0A0R4IWN6
swissprot - Q4H4B6
swissprot - A0A1L1QZM7
swissprot - A0A1L1QZF0
ZFIN ID - ZDB-GENE-030616-572
Ensembl - ENSDARG00000000861
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SCRIBENSGALG00000032790Gallus gallus
 SCRIBENSG00000180900Homo sapiens
 ScribENSMUSG00000022568Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
lrrc7 / leucine rich repeat containing 7 / Q96NW7*ENSDARG0000007967019
erbin / erbb2 interacting protein / Q80TH2* / Q96RT1*ENSDARG0000004428118
lrrc1 / leucine rich repeat containing 1 / Q9BTT6*ENSDARG0000010268415
mfhas1 / malignant fibrous histiocytoma amplified sequence 1 / Q3V1N1* / Q9Y4C4* / Malignant fibrous histiocytoma-amplified sequence 1 homolog *ENSDARG0000007910410
shoc2 / Q1L8Y7 / SHOC2 leucine-rich repeat scaffold protein / O88520* / Q9UQ13* / Mus musculus soc-2 (suppressor of clear) homolog (C. elegans) (Shoc2), transcript variant 3, mRNA.*ENSDARG000000408539
lrrc40 / leucine rich repeat containing 40 / Q9H9A6* / leucine-rich repeat-containing protein 40 isoform b *ENSDARG000000177087
ascl1b / achaete-scute family bHLH transcription factor 1bENSDARG000000097027
lrrc10 / leucine rich repeat containing 10 / Q5BKY1* / Q8K3W2* / Leucine-rich repeat-containing protein 10 *ENSDARG000000456124
lrrc30a / leucine rich repeat containing 30a / A6NM36* / LRRC30* / leucine rich repeat containing 30*ENSDARG000000297103


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000132 establishment of mitotic spindle orientation IMP
 biological_processGO:0001736 establishment of planar polarity IMP
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0001944 vasculature development IMP
 biological_processGO:0007268 chemical synaptic transmission IBA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008283 cell proliferation ISS
 biological_processGO:0014021 secondary neural tube formation IMP
 biological_processGO:0016477 cell migration ISS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0033564 anterior/posterior axon guidance IMP
 biological_processGO:0035089 establishment of apical/basal cell polarity ISS
 biological_processGO:0043065 positive regulation of apoptotic process ISS
 biological_processGO:0043113 receptor clustering IBA
 biological_processGO:0045197 establishment or maintenance of epithelial cell apical/basal polarity IBA
 biological_processGO:0045930 negative regulation of mitotic cell cycle ISS
 biological_processGO:0046037 GMP metabolic process IEA
 biological_processGO:0046710 GDP metabolic process IEA
 biological_processGO:0050918 positive chemotaxis ISS
 biological_processGO:0060027 convergent extension involved in gastrulation IGI
 biological_processGO:0060561 apoptotic process involved in morphogenesis ISS
 biological_processGO:0071679 commissural neuron axon guidance IMP
 biological_processGO:0090630 activation of GTPase activity ISS
 biological_processGO:0097120 receptor localization to synapse IBA
 biological_processGO:0097475 motor neuron migration IGI
 biological_processGO:0098609 cell-cell adhesion ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0005911 cell-cell junction ISS
 cellular_componentGO:0005912 adherens junction IEA
 cellular_componentGO:0005913 cell-cell adherens junction ISS
 cellular_componentGO:0008328 ionotropic glutamate receptor complex IBA
 cellular_componentGO:0014069 postsynaptic density IBA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016323 basolateral plasma membrane IBA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031252 cell leading edge ISS
 cellular_componentGO:0042734 presynaptic membrane ISS
 cellular_componentGO:0045211 postsynaptic membrane IBA
 molecular_functionGO:0004385 guanylate kinase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035255 ionotropic glutamate receptor binding IBA
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000022 floor plate floor plate establishment of planar polarity process quality , abnormal
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 ZFA:0000037 anatomical structure anatomical structure increased distribution , abnormal
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 ZFA:0000092 axis axis decreased length , abnormal
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 ZFA:0000106 extension extension decreased length , abnormal
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 ZFA:0000110 fourth ventricle fourth ventricle malformed , abnormal
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 ZFA:0000131 neural keel neural keel neuroepithelial cell disorganized , abnormal
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 ZFA:0000133 neural rod neural rod neuroepithelial cell disorganized , abnormal
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 ZFA:0000151 pronephros pronephros cystic , abnormal
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 ZFA:0000155 somite somite increased width , abnormal
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 ZFA:0000206 facial nerve motor nucleus facial nerve motor nucleus mislocalised , abnormal
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 ZFA:0000938 central canal central canal branched , abnormal
central canal disorganized , abnormal
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 ZFA:0001094 whole organism whole organism quality , abnormal
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 ZFA:0001114 head head hemorrhagic , abnormal
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 ZFA:0001117 post-vent region post-vent region decreased length , abnormal
post-vent region curved dorsal , abnormal
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 ZFA:0001135 neural tube neural tube neuroepithelial cell disorganized , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage deformed , abnormal
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 ZFA:0001267 cranial vasculature cranial vasculature malformed , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel decreased length , abnormal
intersegmental vessel vasculature development delayed , abnormal
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 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage bent , abnormal
ceratohyal cartilage deformed , abnormal
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 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage deformed , abnormal
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 ZFA:0005175 CoPA CoPA axon misrouted , abnormal
CoPA axon mislocalised posteriorly , abnormal
CoPA anterior/posterior axon guidance process quality , abnormal
CoPA anterior/posterior axon guidance decreased process quality , abnormal
CoPA dorsal spinal cord interneuron anterior axon guidance decreased process quality , abnormal
CoPA neuron projection misrouted , abnormal
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 ZFA:0009306 neuroepithelial cell neuroepithelial cell mitotic spindle direction , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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