ENSDARG00000086585


Danio rerio

Features
Gene ID: ENSDARG00000086585
  
Biological name :nrg2b
  
Synonyms : neuregulin 2b / nrg2b
  
Possible biological names infered from orthology : neuregulin 2 / NRG2 / O14511
  
Species: Danio rerio
  
Chr. number: 14
Strand: 1
Band:
Gene start: 8275115
Gene end: 8438069
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000108874
Ensembl peptide - ENSDARP00000140639
Ensembl peptide - ENSDARP00000136138
Ensembl peptide - ENSDARP00000109596
NCBI entrez gene - 100270726     See in Manteia.
RefSeq - NM_001145091
RefSeq Peptide - NP_001138563
swissprot - A0A0R4INJ1
swissprot - E7FGA4
swissprot - F1QFX4
swissprot - A0A0R4IW84
ZFIN ID - ZDB-GENE-090205-2
Ensembl - ENSDARG00000086585
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NRG2ENSGALG00000033641Gallus gallus
 NRG2ENSG00000158458Homo sapiens
 Nrg2ENSMUSG00000060275Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nrg2a / neuregulin 2a / NRG2* / O14511* / neuregulin 2*ENSDARG0000007781842
nrg1 / neuregulin 1 / Q02297*ENSDARG0000010431432
nrg3b / neuregulin 3b / NRG3* / O35181* / P56975* / neuregulin 3* / Pro-neuregulin-3, membrane-bound isoform Neuregulin-3*ENSDARG0000008976612
CR749775.2ENSDARG000001171059


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR002154  Neuregulin, C-terminal
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013032  EGF-like, conserved site
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0048513 animal organ development IBA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005102 signaling receptor binding IBA


Pathways (from Reactome)
Pathway description
Signaling by ERBB2
Signaling by ERBB4
SHC1 events in ERBB2 signaling
PI3K events in ERBB4 signaling
SHC1 events in ERBB4 signaling
PIP3 activates AKT signaling
GRB7 events in ERBB2 signaling
Downregulation of ERBB2:ERBB3 signaling
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
ERBB2 Activates PTK6 Signaling
Downregulation of ERBB2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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