20963


Mus musculus (NCBI)

Features
Gene ID: 20963
  
Biological name :
  
Synonyms : spleen tyrosine kinase / Syk / Sykb
  
Possible biological names infered from orthology :
  
Species: Mus musculus (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 1418261_at (Mouse Genome 430 2.0 Array)   1418262_at (Mouse Genome 430 2.0 Array)   1425797_a_at (Mouse Genome 430 2.0 Array)   1457239_at (Mouse Genome 430 2.0 Array)   
  
Cross references: RefSeq - XP_017170960.1
RefSeq - 1039743480
RefSeq - 312176429
RefSeq - 56550045
RefSeq - 568982441
RefSeq - 568982443
RefSeq - 568982445
RefSeq - NC_000079.6
RefSeq - NP_001185906.1
RefSeq - NP_035648.2
RefSeq - XP_006516958.1
RefSeq - XP_006516959.1
RefSeq - XP_006516960.1
RefSeq - XP_017170959.1
RefSeq - 1039743478
RefSeq - NM_001198977.1
RefSeq - NM_011518.2
RefSeq - XM_017315470.1
RefSeq - XM_017315471.1
RefSeq - XM_006516895.3
RefSeq - XM_006516896.3
RefSeq - XM_006516897.3
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSMUSG00000021457 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IMP
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001820 serotonin secretion IMP
 biological_processGO:0001945 lymph vessel development IMP
 biological_processGO:0002092 positive regulation of receptor internalization IMP
 biological_processGO:0002250 adaptive immune response IBA
 biological_processGO:0002281 macrophage activation involved in immune response IMP
 biological_processGO:0002283 neutrophil activation involved in immune response IMP
 biological_processGO:0002366 leukocyte activation involved in immune response IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002554 serotonin secretion by platelet IMP
 biological_processGO:0006468 protein phosphorylation ISO
 biological_processGO:0006606 protein import into nucleus ISO
 biological_processGO:0007159 leukocyte cell-cell adhesion ISO
 biological_processGO:0007166 cell surface receptor signaling pathway IMP
 biological_processGO:0007167 enzyme linked receptor protein signaling pathway IDA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007229 integrin-mediated signaling pathway IMP
 biological_processGO:0007257 activation of JUN kinase activity IMP
 biological_processGO:0010543 regulation of platelet activation IMP
 biological_processGO:0010803 regulation of tumor necrosis factor-mediated signaling pathway ISO
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IMP
 biological_processGO:0019370 leukotriene biosynthetic process IMP
 biological_processGO:0030593 neutrophil chemotaxis ISO
 biological_processGO:0031623 receptor internalization IDA
 biological_processGO:0032481 positive regulation of type I interferon production IMP
 biological_processGO:0032753 positive regulation of interleukin-4 production IMP
 biological_processGO:0032928 regulation of superoxide anion generation IMP
 biological_processGO:0033630 positive regulation of cell adhesion mediated by integrin IMP
 biological_processGO:0035556 intracellular signal transduction IMP
 biological_processGO:0038063 collagen-activated tyrosine kinase receptor signaling pathway IMP
 biological_processGO:0038156 interleukin-3-mediated signaling pathway IMP
 biological_processGO:0042742 defense response to bacterium IMP
 biological_processGO:0043306 positive regulation of mast cell degranulation ISO
 biological_processGO:0043313 regulation of neutrophil degranulation IMP
 biological_processGO:0043366 beta selection IGI
 biological_processGO:0045087 innate immune response IMP
 biological_processGO:0045401 positive regulation of interleukin-3 biosynthetic process IMP
 biological_processGO:0045425 positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process IMP
 biological_processGO:0045579 positive regulation of B cell differentiation ISO
 biological_processGO:0045588 positive regulation of gamma-delta T cell differentiation IMP
 biological_processGO:0045780 positive regulation of bone resorption IMP
 biological_processGO:0046638 positive regulation of alpha-beta T cell differentiation IGI
 biological_processGO:0046641 positive regulation of alpha-beta T cell proliferation IGI
 biological_processGO:0046777 protein autophosphorylation ISO
 biological_processGO:0048514 blood vessel morphogenesis IMP
 biological_processGO:0050715 positive regulation of cytokine secretion IGI
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IMP
 biological_processGO:0050764 regulation of phagocytosis IMP
 biological_processGO:0050776 regulation of immune response ISO
 biological_processGO:0050850 positive regulation of calcium-mediated signaling IMP
 biological_processGO:0050853 B cell receptor signaling pathway IDA
 biological_processGO:0051090 regulation of DNA-binding transcription factor activity ISO
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0071226 cellular response to molecule of fungal origin IMP
 biological_processGO:0071404 cellular response to low-density lipoprotein particle stimulus IDA
 biological_processGO:0090237 regulation of arachidonic acid secretion IMP
 biological_processGO:0090330 regulation of platelet aggregation IMP
 biological_processGO:1900086 positive regulation of peptidyl-tyrosine autophosphorylation IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0019815 B cell receptor complex IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032009 early phagosome IDA
 cellular_componentGO:0032991 protein-containing complex ISO
 cellular_componentGO:0042101 T cell receptor complex ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001784 phosphotyrosine residue binding ISO
 molecular_functionGO:0004672 protein kinase activity ISO
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0004713 protein tyrosine kinase activity ISO
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity ISO
 molecular_functionGO:0005178 integrin binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0019902 phosphatase binding IPI
 molecular_functionGO:0019904 protein domain specific binding ISO
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0035325 Toll-like receptor binding IPI
 molecular_functionGO:0042169 SH2 domain binding IDA


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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