ENSMUSG00000026207


Mus musculus

Features
Gene ID: ENSMUSG00000026207
  
Biological name :Speg
  
Synonyms : Q62407 / Speg / SPEG complex locus
  
Possible biological names infered from orthology : Q15772
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C4
Gene start: 75375297
Gene end: 75432320
  
Corresponding Affymetrix probe sets: 10347593 (MoGene1.0st)   1417305_at (Mouse Genome 430 2.0 Array)   1425968_s_at (Mouse Genome 430 2.0 Array)   1448664_a_at (Mouse Genome 430 2.0 Array)   1451886_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113646
Ensembl peptide - ENSMUSP00000109220
Ensembl peptide - ENSMUSP00000116953
Ensembl peptide - ENSMUSP00000141009
Ensembl peptide - ENSMUSP00000121825
Ensembl peptide - ENSMUSP00000119969
Ensembl peptide - ENSMUSP00000084361
Ensembl peptide - ENSMUSP00000109217
Ensembl peptide - ENSMUSP00000109218
Ensembl peptide - ENSMUSP00000109219
NCBI entrez gene - 11790     See in Manteia.
MGI - MGI:109282
RefSeq - XM_017322375
RefSeq - XM_006496404
RefSeq - XM_011238643
RefSeq - XM_011238644
RefSeq - XM_011238645
RefSeq - XM_011238646
RefSeq - XM_011238647
RefSeq - XM_011238648
RefSeq - XM_011238649
RefSeq - XM_011238651
RefSeq - XM_017312276
RefSeq - XM_017322354
RefSeq - NM_001085370
RefSeq - NM_001085371
RefSeq - NM_001173477
RefSeq - NM_007463
RefSeq - XM_006496400
RefSeq - XM_006496401
RefSeq - XM_006496402
RefSeq - XM_006496403
RefSeq Peptide - NP_001078840
RefSeq Peptide - NP_001166948
RefSeq Peptide - NP_031489
RefSeq Peptide - NP_001078839
swissprot - A0A0R4J1J0
swissprot - A0A087WSE3
swissprot - E9QQ25
swissprot - Q62407
swissprot - D6RI69
swissprot - D3Z7T0
swissprot - F6RU40
Ensembl - ENSMUSG00000026207
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 spegaENSDARG00000039256Danio rerio
 spegbENSDARG00000009567Danio rerio
 ENSGALG00000036973Gallus gallus
 ENSGALG00000043198Gallus gallus
 SPEGENSG00000072195Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mylk / myosin light chain kinase / Q15746*ENSMUSG0000002283612
Dapk1 / Q80YE7 / Death-associated protein kinase 1 / P53355*ENSMUSG000000215597
Mylk3 / Q3UIZ8 / Myosin light chain kinase 3 / Q32MK0*ENSMUSG000000316985
Dapk3 / O54784 / Death-associated protein kinase 3 / O43293*ENSMUSG000000349744
Mylk2 / Q8VCR8 / Myosin light chain kinase 2, skeletal/cardiac muscle / Q9H1R3* / myosin light chain kinase 2*ENSMUSG000000274704
Q8BG48 / Stk17b / Serine/threonine-protein kinase 17B / O94768* / serine/threonine kinase 17b*ENSMUSG000000260943
Mylk4 / myosin light chain kinase family member 4 / Q86YV6*ENSMUSG000000449513
Dapk2 / Q8VDF3 / Death-associated protein kinase 2 / Q9UIK4*ENSMUSG000000323803


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR015726  Serine/threonine protein kinase, striated muscle-specific
 IPR017441  Protein kinase, ATP binding site
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0042692 muscle cell differentiation IEA
 biological_processGO:0055013 cardiac muscle cell development IMP
 biological_processGO:0060541 respiratory system development IMP
 biological_processGO:0072358 cardiovascular system development IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Spata22tm1b(KOMP)Wtsi/Spata22tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Spata22tm1b(KOMP)Wtsi/Ucd

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: T5J/t6
Genetic Background: involves: C57BL/6J

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: T5J/t6
Genetic Background: involves: C57BL/6J

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: T5J/t6
Genetic Background: involves: C57BL/6J

 MP:0003057 abnormal epicardium morphology "anomalous structure of the visceral layer of the pericardium that surrounds and attaches to all the surfaces of the heart" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: T5J/t6
Genetic Background: involves: C57BL/6J

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
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Allelic Composition: T5J/t6
Genetic Background: involves: C57BL/6J

 MP:0004062 dilated right atrium "an expansion in the volume of the right upper chamber of the heart" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: T5J/t6
Genetic Background: involves: C57BL/6J

 MP:0004063 dilated left atrium "an expansion in the volume of the left upper chamber of the heart" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: T5J/t6
Genetic Background: involves: C57BL/6J

 MP:0004937 dilated heart "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: T5J/t6
Genetic Background: involves: C57BL/6J

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: T5J/t6
Genetic Background: involves: C57BL/6J

 MP:0008022 dilated heart ventricles "the lumenal space of the lower chambers of the heart is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: T5J/t6
Genetic Background: involves: C57BL/6J

 MP:0008788 abnormal fetal cardiomyocyte morphology "any structural anomaly of fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [PMID:17429040]
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Allelic Composition: T5J/t6
Genetic Background: involves: C57BL/6J

 MP:0010551 abnormal coronary vessel morphology "any structural anomaly of any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: T5J/t6
Genetic Background: involves: C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: T5J/t6
Genetic Background: involves: C57BL/6J

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: T5J/t6
Genetic Background: involves: C57BL/6J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Smurf2tm1b(EUCOMM)Wtsi/Smurf2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smurf2tm1b(EUCOMM)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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