ENSG00000167657


Homo sapiens

Features
Gene ID: ENSG00000167657
  
Biological name :DAPK3
  
Synonyms : DAPK3 / death associated protein kinase 3 / O43293
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.3
Gene start: 3958453
Gene end: 3971123
  
Corresponding Affymetrix probe sets: 203890_s_at (Human Genome U133 Plus 2.0 Array)   203891_s_at (Human Genome U133 Plus 2.0 Array)   228681_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000471154
Ensembl peptide - ENSP00000472988
Ensembl peptide - ENSP00000301264
Ensembl peptide - ENSP00000442973
Ensembl peptide - ENSP00000470115
Ensembl peptide - ENSP00000470168
NCBI entrez gene - 1613     See in Manteia.
OMIM - 603289
RefSeq - XM_005259508
RefSeq - NM_001348
RefSeq Peptide - NP_001339
swissprot - M0R0D0
swissprot - M0QYW5
swissprot - O43293
swissprot - M0QYY8
Ensembl - ENSG00000167657
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dapk3ENSDARG00000074447Danio rerio
 DAPK3ENSGALG00000037733Gallus gallus
 Dapk3ENSMUSG00000034974Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DAPK1 / P53355 / death associated protein kinase 1ENSG0000019673059
DAPK2 / Q9UIK4 / death associated protein kinase 2ENSG0000003566450
MYLK / Q15746 / myosin light chain kinaseENSG0000006553432
O94768 / STK17B / serine/threonine kinase 17bENSG0000008132029
MYLK3 / Q32MK0 / myosin light chain kinase 3ENSG0000014079529
Q9UEE5 / STK17A / serine/threonine kinase 17aENSG0000016454328
MYLK2 / Q9H1R3 / myosin light chain kinase 2ENSG0000010130626
SPEG / Q15772 / SPEG complex locusENSG0000007219526
MYLK4 / Q86YV6 / myosin light chain kinase family member 4ENSG0000014594926


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated TAS
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006915 apoptotic process IMP
 biological_processGO:0006940 regulation of smooth muscle contraction TAS
 biological_processGO:0007088 regulation of mitotic nuclear division TAS
 biological_processGO:0007346 regulation of mitotic cell cycle IMP
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0010506 regulation of autophagy TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0017148 negative regulation of translation IDA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IBA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0042981 regulation of apoptotic process TAS
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0043519 regulation of myosin II filament organization IEA
 biological_processGO:0046777 protein autophosphorylation TAS
 biological_processGO:0051893 regulation of focal adhesion assembly IDA
 biological_processGO:0071346 cellular response to interferon-gamma IDA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IMP
 biological_processGO:0097190 apoptotic signaling pathway IEA
 biological_processGO:2000145 regulation of cell motility TAS
 biological_processGO:2000249 regulation of actin cytoskeleton reorganization TAS
 biological_processGO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005884 actin filament IEA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008140 cAMP response element binding protein binding TAS
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017048 Rho GTPase binding IDA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0043522 leucine zipper domain binding IPI


Pathways (from Reactome)
Pathway description
via Dependence Receptors in the absence of ligand


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr