ENSG00000140795


Homo sapiens

Features
Gene ID: ENSG00000140795
  
Biological name :MYLK3
  
Synonyms : MYLK3 / myosin light chain kinase 3 / Q32MK0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: q11.2
Gene start: 46703369
Gene end: 46790407
  
Corresponding Affymetrix probe sets: 1562411_at (Human Genome U133 Plus 2.0 Array)   1568925_at (Human Genome U133 Plus 2.0 Array)   1568926_x_at (Human Genome U133 Plus 2.0 Array)   217623_at (Human Genome U133 Plus 2.0 Array)   238834_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000378288
Ensembl peptide - ENSP00000439297
NCBI entrez gene - 91807     See in Manteia.
OMIM - 612147
RefSeq - XM_006721334
RefSeq - NM_001308301
RefSeq - NM_182493
RefSeq Peptide - NP_872299
RefSeq Peptide - NP_001295230
swissprot - Q32MK0
Ensembl - ENSG00000140795
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mylk3ENSDARG00000076348Danio rerio
 MYLK3ENSGALG00000004334Gallus gallus
 Mylk3ENSMUSG00000031698Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MYLK2 / Q9H1R3 / myosin light chain kinase 2ENSG0000010130632
MYLK / Q15746 / myosin light chain kinaseENSG0000006553431
MYLK4 / Q86YV6 / myosin light chain kinase family member 4ENSG0000014594927
SPEG / Q15772 / SPEG complex locusENSG0000007219524
DAPK3 / O43293 / death associated protein kinase 3ENSG0000016765716
DAPK1 / P53355 / death associated protein kinase 1ENSG0000019673016
Q9UEE5 / STK17A / serine/threonine kinase 17aENSG0000016454315
DAPK2 / Q9UIK4 / death associated protein kinase 2ENSG0000003566415
O94768 / STK17B / serine/threonine kinase 17bENSG0000008132014


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002528 regulation of vascular permeability involved in acute inflammatory response IMP
 biological_processGO:0006468 protein phosphorylation ISS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IBA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0045214 sarcomere organization ISS
 biological_processGO:0048769 sarcomerogenesis IBA
 biological_processGO:0055003 cardiac myofibril assembly IBA
 biological_processGO:0060298 positive regulation of sarcomere organization ISS
 biological_processGO:0071347 cellular response to interleukin-1 IMP
 cellular_componentGO:0005622 intracellular IBA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0015629 actin cytoskeleton IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004683 calmodulin-dependent protein kinase activity ISS
 molecular_functionGO:0004687 myosin light chain kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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