ENSMUSG00000056972


Mus musculus

Features
Gene ID: ENSMUSG00000056972
  
Biological name :Magel2
  
Synonyms : Magel2 / MAGE-like protein 2 / Q9QZ04
  
Possible biological names infered from orthology : MAGE family member L2 / Q9UJ55
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: C
Gene start: 62377010
Gene end: 62381640
  
Corresponding Affymetrix probe sets: 10553835 (MoGene1.0st)   1417217_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000079265
NCBI entrez gene - 27385     See in Manteia.
MGI - MGI:1351648
RefSeq - NM_013779
RefSeq Peptide - NP_038807
swissprot - Q9QZ04
Ensembl - ENSMUSG00000056972
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ndnl2ENSDARG00000058212Danio rerio
 MAGEL2ENSG00000254585Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tro / trophinin / Q12816*ENSMUSG0000002527212
Maged2 / Mus musculus melanoma antigen, family D, 2 (Maged2), transcript variant 4, mRNA. / Q9UNF1* / MAGE family member D2*ENSMUSG0000002526811
Maged1 / Q9QYH6 / Melanoma-associated antigen D1 / Q9Y5V3* / MAGE family member D1*ENSMUSG0000002515111
Magee1 / Q6PCZ4 / Melanoma-associated antigen E1 / Q9HCI5* / MAGE family member E1*ENSMUSG0000003122710
Nsmce3 / Q9CPR8 / Non-structural maintenance of chromosomes element 3 homolog / Q96MG7* / NSE3 homolog, SMC5-SMC6 complex component*ENSMUSG000000705207
Ndn / P25233 / Necdin / Q99608* / necdin, MAGE family member*ENSMUSG000000335857
1700020D05Rik / RIKEN cDNA 1700020D05 gene / NSMCE3* / Q96MG7* / NSE3 homolog, SMC5-SMC6 complex component*ENSMUSG000001009377
Magee2 / MAGE family member E2 / Q8TD90*ENSMUSG000000312247
Mageb2 / Q8N7X4* / MAGEB6* / MAGEB6B* / MAGE family member B6* / MAGE family member B6B*ENSMUSG000000730697
Magea10 / P43363* / MAGE family member A10*ENSMUSG000000434537
Mageb1 / Q8N7X4* / MAGEB6* / MAGEB6B* / MAGE family member B6* / MAGE family member B6B*ENSMUSG000000621627
Mageb3 / Q8N7X4* / MAGEB6* / MAGEB6B* / MAGE family member B6* / MAGE family member B6B*ENSMUSG000000748817
Mageb4 / A2A9R3 / Melanoma-associated antigen B4 / P43366* / MAGEB1* / MAGEB2* / O15479* / O15481* / MAGE family member B1* / MAGE family member B4* / MAGE family member B2*ENSMUSG000000354277
4933402E13Rik / RIKEN cDNA 4933402E13 geneENSMUSG000000453306
Gm44ENSMUSG000000914976
Gm14781 / MAGEB5* / Q9BZ81* / MAGE family member B5*ENSMUSG000000641296
Q8BQR7 / Mageb18 / Melanoma-associated antigen B18 / Q96M61* / MAGE family member B18*ENSMUSG000000676496
Magea3 / P43363* / MAGEA10* / MAGE family member A10*ENSMUSG000000941966
3830417A13Rik / RIKEN cDNA 3830417A13 gene / P43363* / MAGEA10* / MAGE family member A10*ENSMUSG000000311796
Magea8 / melanoma antigen, family A, 8 / P43363* / MAGEA10* / MAGE family member A10*ENSMUSG000000793506


Protein motifs (from Interpro)
Interpro ID Name
 IPR002190  MAGE homology domain
 IPR037445  Melanoma-associated antigen


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0034314 Arp2/3 complex-mediated actin nucleation IEA
 biological_processGO:0042147 retrograde transport, endosome to Golgi IEA
 biological_processGO:0042752 regulation of circadian rhythm IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0051127 positive regulation of actin nucleation IGI
 biological_processGO:0070534 protein K63-linked ubiquitination IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome ISS
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0030904 retromer complex IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000161 scoliosis "lateral and rotational curvature of the spine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53770, J:66943]
Show

Allelic Composition: Magel2tm1Stw/Magel2tm1Stw
Genetic Background: C57BL/6-Magel2tm1Stw/J

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cry2tm1.1Yf/Cry2tm1.1Yf
Genetic Background: B6J.Cg-Cry2tm1.1Yf

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Jdp2tm1Kkyo/Jdp2tm1Kkyo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001385 pup cannibalization "the killing and eating of newborn mice by the mother; can be a normal response if the mother does not recognize the pups as her own" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoetm1Bres/Apoetm1Bres
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Il2tm1Hor/Il2tm1Hor,Tg(Pgk1-HA)1.1Vbo/?,Tg(Tcra/Tcrb)1Vbo/?
Genetic Background: C.Cg-Il2tm1Hor Tg(Pgk1-HA)1.1Vbo Tg(Tcra/Tcrb)1Vbo

Allelic Composition: Magel2tm1Stw/Magel2tm1Stw
Genetic Background: C57BL/6-Magel2tm1Stw/J

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
Show

Allelic Composition: Jdp2tm1Kkyo/Jdp2tm1Kkyo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001752 abnormal hypothalamus secretion "altered ability of the hypothalamus to release its contents" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Jdp2tm1Kkyo/Jdp2tm1Kkyo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Il2tm1Hor/Il2tm1Hor,Tg(Pgk1-HA)1.1Vbo/?,Tg(Tcra/Tcrb)1Vbo/?
Genetic Background: C.Cg-Il2tm1Hor Tg(Pgk1-HA)1.1Vbo Tg(Tcra/Tcrb)1Vbo

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoetm1Bres/Apoetm1Bres
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002636 delayed vaginal opening "the opening of the genital canal in a female occuring at a later than expected age" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apoetm1Bres/Apoetm1Bres
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002679 abnormal corpora lutea "malformed or absent yellow endocrine body formed in the ovary after follicle rupture" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoetm1Bres/Apoetm1Bres
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Magel2tm1Stw/Magel2tm1Stw
Genetic Background: C57BL/6-Magel2tm1Stw/J

 MP:0002780 decreased circulating testosterone level "less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoetm1Bres/Apoetm1Bres
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003122 maternal imprinting "specific loci are inactivated during oogenesis and are not expressed in offspring" [llw2:Linda Washburn, Mouse Genome Informatics Curator, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Il2tm1Hor/Il2tm1Hor,Tg(Pgk1-HA)1.1Vbo/?,Tg(Tcra/Tcrb)1Vbo/?
Genetic Background: C.Cg-Il2tm1Hor Tg(Pgk1-HA)1.1Vbo Tg(Tcra/Tcrb)1Vbo

Allelic Composition: Magel2tm1Stw/Magel2+
Genetic Background: C57BL/6-Magel2tm1Stw

 MP:0003377 late onset of menarche "the onset of menstrual cycles occurs at a later age than normal" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Magel2tm1Stw/Magel2+
Genetic Background: C57BL/6-Magel2tm1Stw

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Magel2tm1Stw/Magel2tm1Stw
Genetic Background: C57BL/6-Magel2tm1Stw/J

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Jdp2tm1Kkyo/Jdp2tm1Kkyo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Magel2tm1Stw/Magel2tm1Stw
Genetic Background: C57BL/6-Magel2tm1Stw/J

 MP:0008544 impaired olfaction "reduced ability to detect odors" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Magel2tm1Stw/Magel2+
Genetic Background: C57BL/6-Magel2tm1Stw

 MP:0008995 early reproductive senescence "loss of reproductive capacity occurring at an earlier than expected age" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Magel2tm1Stw/Magel2+
Genetic Background: C57BL/6-Magel2tm1Stw

 MP:0009006 prolonged estrous cycle "increase in the length of the sexual cycle of female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Magel2tm1Stw/Magel2+
Genetic Background: C57BL/6-Magel2tm1Stw

 MP:0009013 abnormal proestrus "any anomaly or aberrant timing of the first phase of the estrous cycle which begins when a new batch of eggs reach maturity within ovarian follicles that are ripe and large; external examination of the female usually shows a bloated vulva with an open vagina" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Magel2tm1Stw/Magel2+
Genetic Background: C57BL/6-Magel2tm1Stw

 MP:0009399 increased skeletal muscle fiber size "increase in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Magel2tm1Stw/Magel2tm1Stw
Genetic Background: C57BL/6-Magel2tm1Stw/J

 MP:0009400 decreased skeletal muscle fiber size "decrease in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Magel2tm1Stw/Magel2tm1Stw
Genetic Background: C57BL/6-Magel2tm1Stw/J

 MP:0009417 skeletal muscle atrophy "a wasting of skeletal muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Magel2tm1Stw/Magel2tm1Stw
Genetic Background: C57BL/6-Magel2tm1Stw/J

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Jdp2tm1Kkyo/Jdp2tm1Kkyo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Magel2tm1Stw/Magel2tm1Stw
Genetic Background: C57BL/6-Magel2tm1Stw/J

 MP:0010239 decreased skeletal muscle weight "less than average skeletal muscle weight" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Magel2tm1Stw/Magel2tm1Stw
Genetic Background: C57BL/6-Magel2tm1Stw/J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Il2tm1Hor/Il2tm1Hor,Tg(Pgk1-HA)1.1Vbo/?,Tg(Tcra/Tcrb)1Vbo/?
Genetic Background: C.Cg-Il2tm1Hor Tg(Pgk1-HA)1.1Vbo Tg(Tcra/Tcrb)1Vbo

Allelic Composition: Magel2tm1Stw/Magel2+
Genetic Background: C57BL/6-Magel2tm1Stw

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Jdp2tm1Kkyo/Jdp2tm1Kkyo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Magel2tm1.1Mus/Magel2+
Genetic Background: B6.129S2-Magel2tm1.1Mus

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Magel2tm1Stw/Magel2tm1Stw
Genetic Background: C57BL/6-Magel2tm1Stw/J

 MP:0011957 decreased compensatory feeding amount "decreased amount of food consumed after a period of fasting" [MGI:csmith]
Show

Allelic Composition: Il2tm1Hor/Il2tm1Hor,Tg(Pgk1-HA)1.1Vbo/?,Tg(Tcra/Tcrb)1Vbo/?
Genetic Background: C.Cg-Il2tm1Hor Tg(Pgk1-HA)1.1Vbo Tg(Tcra/Tcrb)1Vbo

 MP:0014142 increased body fat mass "increased physical bulk or volume of fat in the whole body" [MGI:csmith]
Show

Allelic Composition: Magel2tm1Stw/Magel2tm1Stw
Genetic Background: C57BL/6-Magel2tm1Stw/J

 MP:0020467 abnormal circadian behavior "any anomaly in the specific behavior of an organism that recurs with a regularity of approximately 24 hours" [GO:0048512]
Show

Allelic Composition: Il2tm1Hor/Il2tm1Hor,Tg(Pgk1-HA)1.1Vbo/?,Tg(Tcra/Tcrb)1Vbo/?
Genetic Background: C.Cg-Il2tm1Hor Tg(Pgk1-HA)1.1Vbo Tg(Tcra/Tcrb)1Vbo

 MP:0020477 abnormal locomotor circadian rhythm "any anomaly in the rhythm of the locomotor activity of an organism during its 24 hour activity cycle" [GO:0045475]
Show

Allelic Composition: Il2tm1Hor/Il2tm1Hor,Tg(Pgk1-HA)1.1Vbo/?,Tg(Tcra/Tcrb)1Vbo/?
Genetic Background: C.Cg-Il2tm1Hor Tg(Pgk1-HA)1.1Vbo Tg(Tcra/Tcrb)1Vbo

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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