ENSMUSG00000033585


Mus musculus

Features
Gene ID: ENSMUSG00000033585
  
Biological name :Ndn
  
Synonyms : Ndn / Necdin / P25233
  
Possible biological names infered from orthology : necdin, MAGE family member / Q99608
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: C
Gene start: 62346569
Gene end: 62350262
  
Corresponding Affymetrix probe sets: 10553833 (MoGene1.0st)   1415923_at (Mouse Genome 430 2.0 Array)   1435382_at (Mouse Genome 430 2.0 Array)   1435383_x_at (Mouse Genome 430 2.0 Array)   1437853_x_at (Mouse Genome 430 2.0 Array)   1438939_x_at (Mouse Genome 430 2.0 Array)   1438978_x_at (Mouse Genome 430 2.0 Array)   1455792_x_at (Mouse Genome 430 2.0 Array)   1456575_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000045369
NCBI entrez gene - 17984     See in Manteia.
MGI - MGI:97290
RefSeq - NM_010882
RefSeq Peptide - NP_035012
swissprot - P25233
Ensembl - ENSMUSG00000033585
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ndnl2ENSDARG00000058212Danio rerio
 NDNENSG00000182636Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Maged2 / Mus musculus melanoma antigen, family D, 2 (Maged2), transcript variant 4, mRNA. / Q9UNF1* / MAGE family member D2*ENSMUSG0000002526835
Tro / trophinin / Q12816*ENSMUSG0000002527231
Magee1 / Q6PCZ4 / Melanoma-associated antigen E1 / Q9HCI5* / MAGE family member E1*ENSMUSG0000003122728
Mageb1 / Q8N7X4* / MAGEB6* / MAGEB6B* / MAGE family member B6* / MAGE family member B6B*ENSMUSG0000006216227
Mageb3 / Q8N7X4* / MAGEB6* / MAGEB6B* / MAGE family member B6* / MAGE family member B6B*ENSMUSG0000007488127
Nsmce3 / Q9CPR8 / Non-structural maintenance of chromosomes element 3 homolog / Q96MG7* / NSE3 homolog, SMC5-SMC6 complex component*ENSMUSG0000007052027
Maged1 / Q9QYH6 / Melanoma-associated antigen D1 / Q9Y5V3* / MAGE family member D1*ENSMUSG0000002515127
Magel2 / Q9QZ04 / MAGE-like protein 2 / Q9UJ55* / MAGE family member L2*ENSMUSG0000005697227
Mageb2 / Q8N7X4* / MAGEB6* / MAGEB6B* / MAGE family member B6* / MAGE family member B6B*ENSMUSG0000007306927
1700020D05Rik / RIKEN cDNA 1700020D05 gene / NSMCE3* / Q96MG7* / NSE3 homolog, SMC5-SMC6 complex component*ENSMUSG0000010093727
Q8BQR7 / Mageb18 / Melanoma-associated antigen B18 / Q96M61* / MAGE family member B18*ENSMUSG0000006764926
Gm5072 / Q8N7X4* / MAGEB6* / MAGEB6B* / MAGE family member B6* / MAGE family member B6B*ENSMUSG0000009486125
Mageb4 / A2A9R3 / Melanoma-associated antigen B4 / P43366* / MAGEB1* / MAGEB2* / O15479* / O15481* / MAGE family member B1* / MAGE family member B4* / MAGE family member B2*ENSMUSG0000003542725
Gm8914 / Q8N7X4* / MAGEB6* / MAGEB6B* / MAGE family member B6* / MAGE family member B6B*ENSMUSG0000009607225
Magee2 / MAGE family member E2 / Q8TD90*ENSMUSG0000003122425
4933402E13Rik / RIKEN cDNA 4933402E13 geneENSMUSG0000004533024
Q9CWV4 / Mageb16 / Melanoma-associated antigen B16 / A2A368* / MAGE family member B16*ENSMUSG0000004694224
4930550L24Rik / RIKEN cDNA 4930550L24 gene / MAGEC2* / MAGEC3* / Q8TD91* / Q9UBF1* / MAGEC1* / O60732* / MAGE family member C1* / MAGE family member C2* / MAGE family member C3*ENSMUSG0000004618024
Magea10 / P43363* / MAGE family member A10*ENSMUSG0000004345324
3830417A13Rik / RIKEN cDNA 3830417A13 gene / P43363* / MAGEA10* / MAGE family member A10*ENSMUSG0000003117922


Protein motifs (from Interpro)
Interpro ID Name
 IPR002190  MAGE homology domain
 IPR030086  Necdin
 IPR037445  Melanoma-associated antigen


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0003016 respiratory system process IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IGI
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0007413 axonal fasciculation IMP
 biological_processGO:0007417 central nervous system development IMP
 biological_processGO:0007585 respiratory gaseous exchange IMP
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008347 glial cell migration IMP
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0019233 sensory perception of pain IMP
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048011 neurotrophin TRK receptor signaling pathway IMP
 biological_processGO:0048666 neuron development IMP
 biological_processGO:0048675 axon extension IMP
 biological_processGO:0048871 multicellular organismal homeostasis IMP
 biological_processGO:0071514 genetic imprinting IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0042995 cell projection IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043015 gamma-tubulin binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000837 abnormal hypothalamus morphology "any malformation or absence of the ventral part of the diencephalon extending from the region of the optic chiasm to the caudal border of the mammillary bodies and forming the inferior and lateral walls of the third ventricle; this region regulates the autonomic nervous system via hormone production and release" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Aqp7tm1Chan/Aqp7tm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Ndntm1.1Mus/Ndn+
Genetic Background: B6.129S2-Ndntm1.1Mus

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
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Allelic Composition: Pax3Sp-2H/Pax3+
Genetic Background: involves: 101 * C3H/He * CBA/Ca

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pax3Sp-2H/Pax3+
Genetic Background: involves: 101 * C3H/He * CBA/Ca

 MP:0001412 excessive scratching "compulsive scraping of the skin, usually with the nails" [J:61340]
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Allelic Composition: Aqp7tm1Chan/Aqp7tm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Aqp7tm1Chan/Aqp7tm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Insrtm1Dac/Insrtm1Dac,Insrrtm1Dac/Insrrtm1Dac
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

Allelic Composition: Ndntm2Stw/Ndn+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Ndntm1.1Mus/Ndntm1.1Mus
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001943 abnormal respiration "anomaly in the movement of gases into and out of the lung " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ndntm1Stw/Ndn+
Genetic Background: involves: 129S1/Sv * C3H/He * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Insrtm1Dac/Insrtm1Dac,Insrrtm1Dac/Insrrtm1Dac
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

Allelic Composition: Ndntm1Stw/Ndn+
Genetic Background: involves: 129S1/Sv * FVB

Allelic Composition: Ndntm2Stw/Ndn+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Ndntm1.1Mus/Ndntm1.1Mus
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Insrtm1Dac/Insrtm1Dac,Insrrtm1Dac/Insrrtm1Dac
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

Allelic Composition: Ndntm1Stw/Ndn+
Genetic Background: involves: 129S1/Sv * FVB

Allelic Composition: Ndntm1Stw/Ndn+
Genetic Background: involves: 129S1/Sv * C3H/He * C57BL/6

Allelic Composition: Ndntm2Stw/Ndn+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ndntm1.1Mus/Ndntm1.1Mus
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Ndntm1Alb/Ndn+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pax3Sp-2H/Pax3+
Genetic Background: involves: 101 * C3H/He * CBA/Ca

 MP:0002321 hypoventilation "reduced alveolar ventiliation relative to metabolic carbon dioxide production; results in alveolar carbon dioxide pressure increasing above normal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ndntm2Stw/Ndn+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0003122 maternal imprinting "specific loci are inactivated during oogenesis and are not expressed in offspring" [llw2:Linda Washburn, Mouse Genome Informatics Curator, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Insrtm1Dac/Insrtm1Dac,Insrrtm1Dac/Insrrtm1Dac
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

Allelic Composition: Ndntm1Stw/Ndn+
Genetic Background: involves: 129S1/Sv * FVB

Allelic Composition: Ndntm2Stw/Ndn+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Ndntm1Ky/Ndn+
Genetic Background: involves: C57BL/6 * CBA * ICR/Slc

Allelic Composition: Ndntm1.1Mus/Ndn+
Genetic Background: B6.129S2-Ndntm1.1Mus

 MP:0003880 abnormal central pattern generator function "anomalous function of the neural networks that produce rhythmic patterned output without sensory input and underlie rhythmic motor patterns" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:101019]
Show

Allelic Composition: Ndntm2Stw/Ndn+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0003998 decreased thermal nociceptive threshold "a lower than average point at which thermal pain sensation is first detectable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ndntm1.1Mus/Ndn+
Genetic Background: B6.129S2-Ndntm1.1Mus

 MP:0004144 hypotonia "decreased muscle tension resulting in limpness of the muscles in the resting state, not to be confused with weakness" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Insrtm1Dac/Insrtm1Dac,Insrrtm1Dac/Insrrtm1Dac
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

Allelic Composition: Ndntm2Stw/Ndn+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004297 abnormal proprioceptive neuron morphology "any structural anomaly in the sensory neurons of the dorsal root ganglia that sense body position and send information about how much the muscle is stretched to the spinal cord" [MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ndntm1.1Mus/Ndn+
Genetic Background: B6.129S2-Ndntm1.1Mus

 MP:0005039 hypoxia "reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ndntm2Stw/Ndn+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0006404 abnormal lumbar dorsal root ganglion morphology "any structural anomaly of the group of nerve cell bodies located on the dorsal spinal roots within the vertebral column at the level of the lumbar vertebrae" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ndntm1.1Mus/Ndn+
Genetic Background: B6.129S2-Ndntm1.1Mus

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Insrtm1Dac/Insrtm1Dac,Insrrtm1Dac/Insrrtm1Dac
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J

 MP:0010746 abnormal pre-Botzinger complex physiology "any functional anomaly of the group of interneurons within the medulla oblongata s ventral respiratory group that are important for the generation of ventilatory (inspiratory) rhythmogenesis" [PMID:18826652]
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Allelic Composition: Ndntm2Stw/Ndn+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Ndntm2Stw/Ndn+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Ndntm1.1Mus/Ndntm1.1Mus
Genetic Background: involves: 129S2/SvPas * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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