ENSDARG00000042850


Danio rerio

Features
Gene ID: ENSDARG00000042850
  
Biological name :nphs2
  
Synonyms : nephrosis 2, idiopathic, steroid-resistant (podocin) / nphs2
  
Possible biological names infered from orthology : NPHS2, podocin / Podocin / Q91X05 / Q9NP85
  
Species: Danio rerio
  
Chr. number: 22
Strand: -1
Band:
Gene start: 17251275
Gene end: 17256573
  
Corresponding Affymetrix probe sets: Dr.12280.1.A1_at (Zebrafish Array)   NM_001018145_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000062890
Ensembl peptide - ENSDARP00000119695
NCBI entrez gene - 557914     See in Manteia.
RefSeq - NM_001018145
RefSeq Peptide - NP_001018155
swissprot - F6NK55
swissprot - A4FVJ0
swissprot - Q1L982
ZFIN ID - ZDB-GENE-051102-2
Ensembl - ENSDARG00000042850
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NPHS2ENSGALG00000004163Gallus gallus
 NPHS2ENSG00000116218Homo sapiens
 Nphs2ENSMUSG00000026602Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
stom / stomatin / P27105* / P54116* / Erythrocyte band 7 integral membrane protein *ENSDARG0000000383526
stoml3b / stomatin (EPB72)-like 3b / Q8TAV4* / STOML3* / Q6PE84* / stomatin like 3* / stomatin (Epb7.2)-like 3*ENSDARG0000005703525
zgc:112408ENSDARG0000001620725
stoml3a / stomatin (EPB72)-like 3a / Q8TAV4* / STOML3* / stomatin like 3*ENSDARG0000007991424
stoml1 / stomatin (EPB72)-like 1 / Q9UBI4* / stomatin like 1*ENSDARG0000006214217
stoml2 / stomatin (EPB72)-like 2 / Q9UJZ1* / stomatin like 2*ENSDARG0000010313514


Protein motifs (from Interpro)
Interpro ID Name
 IPR001107  Band 7 domain
 IPR001972  Stomatin family
 IPR028509  Podocin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0007588 excretion IEA
 biological_processGO:0031532 actin cytoskeleton reorganization IEA
 biological_processGO:0032835 glomerulus development IMP
 biological_processGO:0039021 pronephric glomerulus development IMP
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Nephrin family interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000106 extension extension edematous , abnormal
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 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
whole organism curved dorsal , abnormal
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 ZFA:0001557 pronephric glomerulus pronephric glomerulus decreased size , abnormal
pronephric glomerulus cystic , abnormal
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 ZFA:0001558 pronephric tubule pronephric tubule increased amount , abnormal
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 ZFA:0005309 pronephric glomerular capillary pronephric glomerular capillary hypotrophic , abnormal
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 ZFA:0009285 podocyte podocyte podocyte foot morphology , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000001634 kirrel1a / kirre like nephrin family adhesion molecule 1a / Q96J84* / Kirrel* / Q80W68* / KIRREL1* / Kin of IRRE-like protein 1 * / kirre like nephrin family adhesion molecule 1*  / complex / reaction
 ENSDARG00000025319 fynb / F1RDG9 / FYN proto-oncogene, Src family tyrosine kinase b / FYN* / P39688* / P06241* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSDARG00000042850 nphs2 / nephrosis 2, idiopathic, steroid-resistant (podocin) / Q9NP85* / Q91X05* / Podocin * / NPHS2, podocin*  / -
 ENSDARG00000056998 kirrel1b / kirre like nephrin family adhesion molecule 1b / Q96J84* / Kirrel* / Q80W68* / KIRREL1* / Kin of IRRE-like protein 1 * / kirre like nephrin family adhesion molecule 1*  / complex / reaction
 ENSDARG00000060758 nphs1 / nephrosis 1, congenital, Finnish type (nephrin) / O60500* / Q9QZS7* / Nephrin * / NPHS1, nephrin*  / reaction / complex
 ENSDARG00000011370 fyna / Q6EWH2 / FYN proto-oncogene, Src family tyrosine kinase a / FYN* / P06241* / P39688* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction






 

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